TIE2 Inhibitors Having a Cyclic Structure and Uses Thereof

Abstract

The present invention relates to a class of TIE2 inhibitors having a cyclic structure and uses thereof. The TIE2 inhibitors having a cyclic structure possess a structure represented by Formula （I ）.The compounds of the general formula of the present invention exhibit high selectivity for TIE2 inhibition across a broad kinase panel. In BaF3-FL-TIE2 L914F cells highly expressing the TIE2 L914F protein, the compounds demonstrate significant anti-proliferative activity.Accordingly, the compounds can be used for the treatment of disorders or diseases mediated by TIE2, such as disorders or diseases associated with TEK gene abnormalities or aberrant protein activity.