Novel long-acting degrader conjugates
TW202637219APending Publication Date: 2026-09-16ASCENDIS PHARM AS
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Patent Information
- Application Number
- TW114147849
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2025-01-13
- Filing Date
- 2025-12-05
- Publication Date
- 2026-09-16
Abstract
The present invention relates to a conjugate or a pharmaceutically acceptable salt thereof comprising at least one moiety -D, which is conjugated via at least one moiety -L1(-L2)a- to at least one moiety -Z, wherein -L1- is conjugated to -D, and wherein -D is a drug moiety comprising at least one receptor-binding moiety -RB and at least one target-binding moiety -TB; -L1- is a reversible linker moiety; -L2- is a spacer moiety; a is
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