Peptides and conjugates containing the peptides

Abstract

[Topic] This invention relates to peptides, conjugates containing the peptide, and compositions containing the same. [Solution] This invention relates to a peptide comprising an amino acid sequence of formula A1 or an amino acid sequence in which one or more amino acid residues of formula A1 are substituted, deleted, added, or inserted. A1: X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13 However, X1 is any D-amino acid residue, X2 is any amino acid residue, X3 is an amino acid residue with a substituted aryl group in the side chain, X4 is any amino acid residue, X5 is an amino acid residue with a substituted aryl group in the side chain, X6 is a glycine residue that can be N-alkylated (the alkyl group may have substituents), X7 is any amino acid residue, X8 is N, X9 is a glycine residue that can be N-alkylated (the alkyl group may have substituted aryl groups), X10 is an amino acid residue with an aliphatic hydrocarbon group in the side chain, X11 is a 4-6 member cyclic secondary amino acid residue, X12 is D, X13 is (1) C or aMeC, or, (2) X13 is A or G, and further adds G, MeG, Medn, Meda, dp or Meds at the C end of X13 as the 14th amino acid residue (X14). In formula A1, the amino acid sequence is described from the N-terminal side to the C-terminal side.

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