Apomorphine salts, their formulations and use thereof

Abstract

Provided are very slightly soluble salts of apomorphine, sustained-release pharmaceutical compositions including the slightly or very slightly soluble salts of apomorphine, and their uses in treating a neurological disease, sexual dysfunction, neuroleptic (-like) malignant syndrome, or an alcohol-related disorder. The very slightly soluble salts of apomorphine are an apomorphine hydroxynaphthoate salt or an apomorphine pamoate salt in a crystal or amorphous form. Also provided are methods for preparing the very slightly soluble salt of apomorphine and its crystal or amorphous form.

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