Antibody-drug conjugate intermediate, preparation method and use thereof
TW202639578APending Publication Date: 2026-10-01CHANGCHUN GENESCIENCE PHARM CO LTD
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Patent Information
- Application Number
- TW114148772
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-12-11
- Filing Date
- 2025-12-11
- Publication Date
- 2026-10-01
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Figure TWG2TA001078779_001 
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Abstract
The present disclosure relates to an antibody-drug conjugate intermediate, a preparation method and use thereof. The antibody-drug conjugate prepared using the intermediate compound represented by Formula IM2' provided herein as an intermediate exhibits favorable biological activity and stability. Moreover, compared with conventional condensation methods or methods involving preparation of an active ester followed by condensation, the preparation method of the present disclosure can avoid racemization of the product and achieves a high yield of the target structure, making it possible to prepare antibody-drug conjugates in subsequent steps.
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