Gene constructs and uses thereof

Abstract

Disclosed herein is a gene construct and use thereof. The gene construct is used to inhibit neuronal hyperexcitation caused by the overuse or abuse of addictive substances. The gene construct comprises a neuronal inhibitory protein-encoding gene and a promoter operably linked to the neuronal inhibitory protein-encoding gene. The gene construct exhibits significant advantages in precise targeting, closed-loop regulation, retention of natural reward response, reduction of side effects, and improvement of safety, as well as potential long-term efficacy and sustainability. This strategy provides new ideas and methods for the treatment of substance use disorders and is expected to become an important breakthrough in the field of substance use disorders in the future.

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