Arrays of integrated analytical devices with improved collection efficiency and use of the arrays in optical analysis

Abstract

Arrays of integrated analytical devices and methods of optical analysis using the devices are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include a nanophotonic patterned structure to increase the efficiency of detection of optical signals emitted from the optical reactions. Also provided are analytical systems containing an optical source and an array of integrated analytical devices.

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