Polyvinyl sulfonate detection and removal from biomolecule compositions

TW202640139APending Publication Date: 2026-10-01AMGEN INC
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Patent Information

Application Number
TW115124424
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2020-10-16
Filing Date
2021-10-15
Publication Date
2026-10-01

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Abstract

The disclosure provides materials and methods for assessing the presence and level of polyanionic compounds in a sample that inhibit PCR reactions, including assays for the presence, and optionally the amount, of polyvinyl sulfonate, as well as materials and methods for the reduction or removal of such compounds from buffer solutions and from protein solutions using a variety of approaches, including titration-based techniques.
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