Compositions and methods for delivery of DNA to t cells

Abstract

The disclosure provides, for example, a targeted lipid nanoparticle composition comprising a lipid nanoparticle, a targeting moiety on the surface of the lipid nanoparticle, wherein the targeting moiety binds a T cell antigen, and a double stranded DNA molecule comprising an effector sequence that encodes an effector. In some embodiments, the targeting moiety comprises an antibody. In some embodiments, the effector comprises a polypeptide. In some embodiments, the double stranded DNA molecule comprises chemically modified nucleobases in its sense strand, and the antisense strand is free of chemically modified nucleobases.

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