Targeted lipid nanoparticles

Abstract

Lipid nanoparticles are provided which comprise a lipid matrix and a GalNAc-containing compound. The nanoparticles are capable of binding to asialoglycoprotein receptors and may thus be used, for example, in the targeted delivery of nucleic acid cargos to cells such as liver cells. Also provided are pharmaceutical compositions comprising the lipid nanoparticles, medical uses thereof, GalNAc-containing compounds per se, and processes for preparing the lipid nanoparticles and GalNAc compounds of the disclosure.

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