Tranexamic acid compressed coated sustained-release tablets, their preparation methods and applications

Abstract

This invention relates to a tranexamic acid compressed-coated sustained-release tablet, its preparation process, and its uses. The sustained-release tablet comprises a core layer and an outer coating layer, exhibiting an asymmetric dual-reservoir structure. Both the core layer and the outer coating layer contain the drug and sustained-release materials. Drug release is controlled by the compressed coating structure and the sustained-release materials, achieving a high-load sustained-release of a highly water-soluble drug. While increasing the tranexamic acid content, the sustained-release effect is better, the release time is longer, and a stable zero-order release is achieved, reducing the likelihood of burst release, lowering toxic side effects, and improving safety and reliability. Furthermore, the sustained-release tablet structure facilitates swallowing, improving patient medication adherence.

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