Proteolysis targeting chimeric compounds targeting c-met and compositions and uses thereof

Abstract

Provided herein are proteolysis targeting chimeric compounds of formulas (I), (II), (III), (IV), (V), (I’), (II’), (III’), (IV’) or (V’) that have degrading and / or inhibitory activity against abnormal c-MET, or tautomers, stereoisomers, prodrugs, crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof, and also provided herein are pharmaceutical compositions comprising the same, as well as methods of preparation and therapeutic uses therefor.