A class of aromatic heterocyclic compounds, their preparation methods and applications

Abstract

This invention provides aromatic heterocyclic compounds, their stereoisomers, tautomers, or pharmaceutically acceptable salts, methods for their preparation, and applications. The compounds of this invention possess regulatory activity on tumor necrosis factor α (TNFα) signaling and / or exhibit excellent cardiac safety, showing potential in the treatment of adverse inflammatory and autoimmune diseases, pain and nociceptive disturbances, neurological and neurodegenerative diseases, cardiovascular diseases, metabolic diseases, oncological diseases, and ocular diseases.