5’-cyclo-phosphonate modified nucleotides

TW202641583APending Publication Date: 2026-10-16ARROWHEAD PHARMACEUTICALS INC
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Patent Information

Application Number
TW114149512
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2016-06-06
Filing Date
2017-06-06
Publication Date
2026-10-16

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Abstract

Described are 5’-cyclo-phosphonate modified nucleotides, and oligonucleotides, such as interference (RNAi) agents, containing 5’-cyclo-phosphonate modified nucleotides. The RNAi agents having either double-stranded or single-stranded oligonucleotides described herein comprising 5’cyclo-phosphonate modified nucleotides are useful in modulating gene expression as well as therapeutic, diagnostic, target validation, and genomic discovery applications. The RNAi agents and single-stranded antisense oligonucleotides comprising 5’-cyclo-phosphonate modified nucleotides are useful in the treatment of diseases or conditions that respond to inhibition of gene expression or activity in a cell, tissue, or organism.
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