Glycan linkers for glycan site-specific antibody-drug conjugates and preparation thereof

TW202641813APending Publication Date: 2026-10-16OBI PHARMA INC
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Patent Information

Application Number
TW114146331
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-11-27
Filing Date
2025-11-27
Publication Date
2026-10-16

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Abstract

The present disclosure relates to a glycan linker and a method for preparing a glycoengineered antibody conjugated with payloads. Also provided herein is an antibody conjugate prepared using the glycoengineered antibody and a preparation method thereof. The present disclosure further provides antibody-drug conjugates (ADCs) targeting several antigens (e.g., TROP2, HER2, Nectin-4, etc.) and pharmaceutical compositions comprising said ADCs. Also described herein are methods of using the ADCs for treatment of diseases such as cancers.
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