Methods and systems for enhanced multispecific metabolic and cellular targeting

Abstract

Materials, methods, and systems are provided for proteins comprising a muscle fortifying agent and metabolic modulatory component. The muscle fortifying agent is, for example, a myostatin modulator or the like, an activin type II receptor modulator or the like, or any and each combination thereof. The metabolic component may be an anti-GIPR antibody or fragment thereof and a metabolic modulator. Exemplary metabolic modulators include GLP-1 receptor agonist. In one aspect, the present invention teaches and describes materials, methods, and systems of metabolic modulation, including modulatory agents. For example, the improved materials, methods, and systems of the present invention include novel agents that regulate metabolism in a host. Included are molecules that specifically bind to one or more than one molecule or target, including multispecific molecules, conjugates of a muscle fortifying agent, and for example an additional active metabolic component directly connected or joined via a linker. In particular, the invention includes conjugates or fusions or the like comprising a muscle fortifying agent in combination with a metabolic modulator, including for example a glucagon-like peptide-1 (GLP-1) receptor binding molecule, such as an agonist, and / or an antagonist of the glucose-dependent insulinotropic peptide receptor (GIPR), etc.; and includes nucleic acids and expression vectors encoding the conjugates, recombinant cells thereof, and compositions comprising the conjugates suitable for development and use in hosts. Materials and methods of producing the modulators and various uses are provided.

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