Compositions and methods for amino acid depletion therapy

TW202641970APending Publication Date: 2026-10-16AVALON POLYTOM HK LTD
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Patent Information

Application Number
TW115100201
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2017-11-27
Filing Date
2018-08-15
Publication Date
2026-10-16

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Abstract

Compositions and methods for the preparation of high purity arginase and high efficiency preparation of monosubstituted polyethylene glycol conjugation of arginase are provided, as are methods for using arginase in combination with asparaginase to inhibit cancer cells. High purity arginase is provided by applying an initial high temperature precipitation step, followed by ion exchange to provide arginase at a purity of
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