Caryophyllene-containing composition

Abstract

The objective of this invention is to provide a novel composition, etc. The composition is configured to contain at least eugenol, menthol, and / or oils.

Description

Technical Field

[0001] This invention relates to a composition containing eugenol, etc. Prior Technology

[0002] Regarding eugenol (β-eugenol), for example, it is known to have anxiolytic effects (Patent Document 1). [Previous Technical Documents] [Patent Literature]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 2006-342062 Summary of the Invention

[0004] [The problem the invention aims to solve]

[0005] As mentioned above, eugenol is known to have anxiolytic effects, but its effects on other components such as menthol and oils [medium- and long-chain triglycerides (MCTs)] are completely unknown.

[0006] In view of this, the object of the present invention is to provide a novel composition containing eugenol, novel functions of eugenol, etc. [Technical means to solve the problem]

[0007] In order to achieve the above-mentioned objectives, the inventors conducted intensive research and found that eugenol can promote the volatilization or dissolution of menthol, and can improve the freeze resistance by forming a composition with menthol and oils (providing a composition with excellent freeze resistance). Further research was conducted, and the present invention was completed.

[0008] That is, this invention relates to the following inventions, etc. [1] A composition comprising eugenol and menthol. [2] A composition comprising eugenol and oils [3] A composition comprising eugenol, menthol and oils. [4] The composition described in [2] or [3] contains oils containing MCT. [5] The composition described in any of [1] to [4] contains eugenol at a rate of 1% or more by mass. [6] The composition described in any of [1], [3] to [5] contains 3% by mass or more of eugenol and the ratio of eugenol to the total amount of eugenol and menthol is 5 to 95 by mass. [7] The composition described in any of [2] to [6] contains 3% or more of eugenol and the ratio of eugenol to the total amount of eugenol and oil is 5 to 95% by mass. [8] The composition described in any of [3] to [7] contains 3% or more of eugenol and the ratio of eugenol to the total amount of eugenol, menthol and oil is 5 to 95% by mass. [9] The composition described in any of [1], [3] to [8] contains 15% by mass or more of menthol.

[10] The composition described in any one of [1] to [9] further comprises at least one component (X) selected from dicarboxylic acid esters, diol esters, monocarboxylic acid esters, esters of polyols having three or more hydroxyl groups, esters of polycarboxylic acids having three or more carboxyl groups, polyol ethers, polyamines, and alcohols having six or more carbon atoms.

[11] The composition described in any of [1] to

[10] further comprises a component (X) as a dicarboxylic acid ester.

[12] The composition described in

[10] or

[11] contains a component (X) in a ratio of 1% by mass or more.

[13] The composition described in any of

[10] to

[12] has a ratio of 3% by mass or more of component (X) and a ratio of component (X) to eugenol and the total amount of component (X) of 5 to 95 by mass.

[14] The composition described in any of [1] to

[13] is liquid.

[15] The composition described in any of [1] to

[14] is used in the contents (core) of a capsule (the contents of a capsule for use in the contents of a capsule).

[16] A capsule comprising a core and a shell, wherein the core is a composition as described in any one of [1] to

[15] .

[17] A filter comprising a capsule, wherein the capsule comprises a core and a shell, and the core is a composition as described in any one of [1] to

[15] .

[18] A cigarette containing a composition as described in any one of [1] to

[15] .

[19] An inhalation device comprising a composition as described in any one of [1] to

[15] .

[20] The inhalation device described in

[19] is a smoking device. [twenty one] The cigarette or smoking device described in any of

[18] to

[20] contains a capsule or filter as described in

[16] or

[17] . [twenty two] A volatile (evaporation rate) enhancer of menthol (or menthol in a composition containing menthol), comprising eugenol. [twenty three] A solubility (dissolution rate) enhancer of menthol (or menthol in a composition containing menthol), comprising eugenol. [twenty four] An agent for improving the freeze resistance of oils, comprising eugenol.

[25] A method for enhancing the volatility and / or solubility of menthol, comprising mixing (contacting) eugenol (an agent containing eugenol) into menthol (or a composition containing menthol) to enhance the volatility and / or solubility of menthol.

[26] A method for improving the freeze resistance of oils involves mixing (contacting, containing) eugenol (an agent containing eugenol) into the oil (a composition containing oils) to improve the freeze resistance of the oil.

[27] A method for pulmonary ingestion of eugenol (and menthol) using a capsule, filter, cigarette and / or inhalation device as described in any of

[16] to

[21] . [Effects of the Invention]

[0009] According to the present invention, a novel composition containing eugenol, novel functions of eugenol, etc., can be provided.

[0010] For example, in one embodiment of the present invention, a composition comprising eugenol and menthol may be provided, an agent comprising eugenol for enhancing (improving, promoting) the volatility or solubility of menthol (or a composition containing menthol), and an agent for enhancing (improving, promoting) the freeze resistance of menthol (or a composition containing menthol), etc.

[0011] Eugenol, in combination with menthol, can promote the volatilization or dissolution of menthol (exhibiting excellent volatility or solubility of menthol in the composition with menthol), or enhance the antifreeze properties of menthol (exhibiting excellent antifreeze properties of menthol in the composition with menthol), thereby providing such a composition or agent.

[0012] Furthermore, in another embodiment of the present invention, a composition comprising eugenol and oils may be provided, as well as an agent comprising eugenol for enhancing (improving, promoting) the freeze resistance of oils (or compositions containing oils).

[0013] Eugenol, in combination with oils (such as MCT), can enhance the antifreeze properties of oils (or exhibit excellent antifreeze properties of oils in a combination with oils), thereby providing such a composition or agent. Implementation

[0014] [Cynocarbamate] The compositions of the present invention [and similarly in specific uses (suitable objects) such as formulations, capsules, filters, inhalation devices, etc.] contain eugenol.

[0015] Examples of eugenols include: β-eugenol, α-eugenol, isoeugenol, and eugenol metabolites or derivatives (such as eugenol oxides like β-eugenol oxide). Eugenols may contain one of these compounds alone or in combination with two or more.

[0016] Typically, eugenol may contain at least β-eugenol, or may contain β-eugenol and eugenol that is not β-eugenol [e.g., selected from at least one of α-eugenol, isoeugenol, eugenol metabolites or derivatives]. In this eugenol containing at least β-eugenol, the proportion of β-eugenol can be, for example, 30% or more by mass, 50% or more by mass, 70% or more by mass, 80% or more by mass, 90% or more by mass, 95% or more by mass, 100% by mass (actually 100% by mass), etc. Furthermore, in this specification, the term "β-eugenol" may sometimes include eugenols that are not β-eugenols, collectively referred to as β-eugenols.

[0017] Eugenol (β-eugenol) is not particularly limited and can be derived from cloves, fennel, basil, jasmine, hops, cinnamon, Ceylon cinnamon, rosemary, hemp, hemp, black pepper, lavender, malabathrum, ylang-ylang, basil, calamari, chili pepper, curry leaves, and other essential oils (such as those that have been extracted or concentrated).

[0018] Furthermore, eugenol can be commercially available or produced (purified) by conventional methods (chemical synthesis).

[0019] There is no particular limitation on the amount of eugenol, and it can be appropriately selected according to the required function (such as promoting volatilization, promoting dissolution, antifreeze properties, and other functions of eugenol), dosage form, etc. For example, in the composition, the amount (ratio, concentration) of eugenol can be 0.01% by mass (weight, wt, the same below) or more (e.g., 0.05% by mass or more), 0.1% by mass or more (e.g., 0.5% by mass or more), 1% by mass or more (e.g., 5% by mass or more), 10% by mass or more (e.g., 15% by mass or more), 20% by mass or more (e.g., 25% by mass or more), 30% by mass or more (e.g., 35% by mass or more), 40% by mass or more (e.g., 45% by mass or more), 50% by mass or more (e.g., 55% by mass or more). The following quantities can be expressed as: above 60% (e.g., above 65% by mass), above 70% (e.g., above 75% by mass), above 80% (e.g., above 85% by mass), above 90% (e.g., above 95% by mass), etc.; or below 99.9% (e.g., below 99.5% by mass), below 99% (e.g., below 95% by mass), below 90% by mass, below 80% by mass, below 70% by mass, below 60% by mass, below 50% by mass, below 40% by mass, below 30% by mass, etc.

[0020] The concentration (ratio) range of eugenol can be set by appropriately combining the lower and upper limits of the above range (e.g., 0.1-90% by mass, 10-50% by mass, etc.) [Furthermore, the range descriptions (e.g., menthol, oils, etc.) in this specification are all the same]. Specific concentration (range) ranges of eugenol can be exemplified as: 1% by mass or more, 3-99% by mass, 5-80% by mass, 5-90% by mass, 15-30% by mass, etc.

[0021] Furthermore, when the composition contains menthol (or when eugenol and menthol are combined), the ratio (concentration) of eugenol to the total amount (total amount) of eugenol and menthol [when the total amount is set to 100% by mass] can also be selected from the above range (e.g., 1% or more by mass, 10% or more by mass, 5 to 90% by mass, etc.).

[0022] Similarly, when the composition contains oils (or when eugenol is combined with oils), the ratio (concentration) of eugenol relative to the total amount (total) of eugenol and oils [when the total amount is set to 100% by mass] can also be selected from the concentration range of eugenol in the above composition (e.g., 1% or more by mass, 10% or more by mass, 5 to 90% by mass, etc.).

[0023] Furthermore, when the composition contains menthol and oil (when eugenol is combined with menthol and oil), the ratio (concentration) of eugenol to the total amount (total quantity) of eugenol, menthol and oil [when the total amount is set to 100% by mass] can also be selected from the concentration range of eugenol in the above composition (e.g., 1% or more by mass, 10% or more by mass, 5 to 90% by mass, etc.).

[0024] Furthermore, when the composition contains the following component (X), the ratio (concentration) of eugenol to the total amount (total measure) of eugenol and component (X) [when the total amount is set to 100% by mass] can also be selected from the concentration range of eugenol in the above composition (e.g., 5% or more by mass, 95% or less by mass, 10 to 90% by mass, etc.).

[0025] Furthermore, regarding eugenol, it is known (reported) to have the following functions, such as relieving (improving, inhibiting) anxiety [e.g., motion sickness, nocturia, stress urticaria], relieving (improving, inhibiting) stress, inhibiting β-secreting enzyme activity, and preventing or improving dementia (or senile dementia, such as Alzheimer's disease). Therefore, the compositions of the present invention can also be used for the purpose of imparting (or obtaining) the above-mentioned functions (effects), but this also depends on the manner of use.

[0026] Menthol The composition may also contain menthol. Regarding menthol, it may typically contain at least L-menthol, or may be substantially L-menthol, depending on the desired function, etc.

[0027] Furthermore, in compositions (e.g., compositions at room temperature or at a temperature below the melting point of menthol), menthol can also dissolve (solid solution) without solidifying (crystallizing, solidifying alone).

[0028] In this composition, the ratio (concentration) of menthol can be appropriately selected according to the desired function (e.g., the function of menthol, and the function of eugenol constituting the composition), dosage form, etc., and is not particularly limited. It can generally be selected from a range of about 0.5% by mass or more (e.g., 1% by mass or more), for example, it can be 2% by mass or more (e.g., 3% by mass or more), 5% by mass or more (e.g., 8% by mass or more), 10% by mass or more (e.g., 12% by mass or more), 15% by mass or more (e.g., 18% by mass or more), 20% by mass or more (e.g., 22% by mass or more), 25% by mass or more (e.g., 28% by mass or more), 30% by mass or more (e.g., 32% by mass or more), 35% by mass or more (e.g., 32% by mass or more). For example, 38% or more by mass), 40% or more by mass (e.g., 42% or more by mass), 45% or more by mass (e.g., 48% or more by mass), 50% or more by mass, etc., or 95% or less by mass (e.g., 90% or less by mass), 80% or less by mass (e.g., 75% or less by mass), 70% or less by mass (e.g., 65% or less by mass), 60% or less by mass (e.g., 55% or less by mass), 50% or less by mass (e.g., 48% or less by mass, 45% or less by mass), 40% or less by mass (e.g., 35% or less by mass), 30% or less by mass (e.g., 28% or less by mass), 25% or less by mass (e.g., 22% or less by mass), 20% or less by mass (e.g., 18% or less by mass), etc.

[0029] Regarding the concentration (ratio) range of menthol, as mentioned above, the lower and upper limits of the above range can be appropriately combined to set a specific range. For example, the ranges could be: 3% or more by mass, 5-70% by mass, 10-65% by mass, 10-60% by mass, 15% or more by mass, 15-55% by mass, 15-45% by mass, etc.

[0030] The concentration (ratio) of menthol can also be relatively high (e.g., 10% by mass or more, 15% by mass or more, 35% by mass or more, 40% by mass or more, etc.). In this invention, by combining eugenol with menthol, even at a high concentration of menthol, the volatilization or dissolution of menthol can be promoted, or excellent antifreeze properties can be achieved.

[0031] The ratio (concentration) of menthol relative to the total amount (total amount) of eugenol and menthol [when the total amount is set to 100% by mass] can also be selected from the concentration range of menthol in the above composition (e.g., 5% or more by mass, 80% or less by mass, 3 to 60% by mass, etc.).

[0032] When the composition contains eugenol, menthol and oil, the ratio (concentration) of menthol relative to the total amount (total quantity) of eugenol, menthol and oil [when the total amount is set to 100% by mass] can also be selected from the concentration range of menthol in the above composition (e.g., 5% or more by mass, 80% or less by mass, 3 to 60% by mass, etc.).

[0033] When the composition contains menthol and the following ingredient (X), the ratio (concentration) of menthol relative to the total amount (total amount) of menthol and ingredient (X) [when the total amount is set to 100% by mass] can also be selected from the concentration range of menthol in the above composition (e.g., 5% or more by mass, 80% or less by mass, 3 to 60% by mass, etc.).

[0034] Furthermore, menthol is known (reported) to have functions such as flavor imparting, cooling effect, and gastric motility inhibition. Therefore, the composition of the present invention can also be used for the purpose of imparting (or obtaining) the above-mentioned functions (effects), but this also depends on its usage.

[0035] [grease] The composition may also contain oils. Examples of fats and oils include: vegetable oils (such as soybean oil, rapeseed oil, corn oil, sesame oil, flaxseed oil, cottonseed oil, perilla oil, olive oil, rice oil, palm oil, jojoba oil, sunflower seed oil, camellia oil, etc.), animal oils (such as tallow, lard, chicken fat, dairy fat, fish oil, horse oil, etc.), and medium- and long-chain triglycerides (MCTs).

[0036] Oils can be used alone or in combination of two or more types.

[0037] MCT is particularly suitable for use in these oils. Therefore, the oil may contain at least MCT. When such an oil contains MCT, the ratio of MCT to the total oil may be, for example, 10% by mass or more, 30% by mass or more, 50% by mass or more, 70% by mass or more, 80% by mass or more, 90% by mass or more, 100% by mass or more (MCT only), etc.

[0038] Besides functioning as a medium (solvent, carrier) in compositions, oils, depending on their type (e.g., MCT), generally exhibit relatively good (or minimally reduced) properties in terms of menthol volatility or solubility, and the freeze resistance of menthol or the oil itself. From this perspective, oils (especially MCT) can appropriately replace a portion of eugenol or similar compounds. Furthermore, the use of oils (MCT, etc.) offers advantages in areas such as encapsulation. Moreover, oils are less likely to affect aroma and are easily used in combinations with menthol or eugenol.

[0039] In the composition, the proportion (amount, concentration) of oil can be, for example, 0.1% by mass or more (e.g., 0.5% by mass or more), 1% by mass or more (e.g., 5% by mass or more), 10% by mass or more (e.g., 15% by mass or more), 20% by mass or more (e.g., 25% by mass or more), 30% by mass or more (e.g., 35% by mass or more), 40% by mass or more (e.g., 45% by mass or more), 50% by mass or more (e.g., 55% by mass or more), 60% by mass or more (e.g., 65% by mass or more), 70% by mass or more (e.g., 75% by mass or more), 80% by mass or more (e.g., 85% by mass or more), 90% by mass or more (e.g., 95% by mass or more), or less than 99% by mass (e.g., less than 95% by mass), less than 90% by mass, less than 80% by mass, less than 70% by mass, less than 60% by mass, less than 50% by mass, less than 40% by mass, less than 30% by mass, less than 20% by mass, etc.

[0040] Similarly, the ratio (concentration) of oil to the total amount (total quantity) of eugenol and oil [when the total amount is set to 100% by mass] can also be selected from the concentration range of oil in the above composition (e.g., 1% or more by mass, 10% or more by mass, 5 to 90% by mass, etc.).

[0041] Furthermore, when the composition contains menthol and oil (when eugenol is combined with menthol and oil), the ratio (concentration) of oil relative to the total amount (total quantity) of eugenol, menthol and oil [when the total amount is set to 100% by mass] can also be selected from the concentration range of oil in the above composition (e.g., 1% or more by mass, 10% or more by mass, 5 to 90% by mass, etc.).

[0042] Furthermore, when the composition contains oil and the following ingredient (X), the ratio (concentration) of the oil to the total amount (total quantity) of the oil and ingredient (X) [when the total amount is set to 100% by mass] can also be selected from the concentration range of the oil in the above composition (e.g., 5% or more by mass, 95% or less by mass, 10 to 90% by mass, etc.).

[0043] [Other ingredients] The composition may also contain other ingredients (other than eugenol, menthol and oils).

[0044] Other ingredients are not particularly limited and can be selected based on the form, purpose, and target audience of the composition. Examples include: carriers, excipients, binders, disintegrants, lubricants, coating agents, colorants, fragrances, stabilizers, emulsifiers (surfactants), absorption enhancers, gelling agents, pH adjusters, preservatives, antioxidants, cooling agents, physiologically active substances, bioactive substances, microorganisms, food and beverages, plants, sweeteners, acidulants, seasonings, tonics, etc.

[0045] Other ingredients can be used alone or in combination of two or more.

[0046] As carriers (mediums, not carriers of oils), examples include: acids (such as fatty acids like caprylic acid, capric acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid, linoleic acid, etc.), hydrocarbons (such as liquid paraffin, squalane, petrolatum), polysiloxanes (such as polysiloxane oils, etc.), synthetic polymers (such as polyacrylic acid, carboxyethylene polymers, polyethylene glycol, polyvinylpyrrolidone, etc.), natural polymers or their derivatives (such as carrageenan, alginate, cellulose, guar gum, senna, quince seeds, dextran, gellan gum, hyaluronic acid, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cationic guar gum, acetylated hyaluronic acid, sodium alginate, etc.), lower alcohols (such as ethanol, isopropanol, etc.), polyols (such as ethylene glycol, glycerin, propylene glycol, butylene glycol, diglycerol, dipropylene glycol), water, etc.

[0047] Furthermore, the properties of the carrier can be selected according to the form of the composition, and it can be solid, liquid, or non-volatile or volatile. Liquid carriers can also be called solvents.

[0048] There are no particular limitations on what can be used as an emulsifier (surfactant). Examples include: nonionic surfactants [such as sugar fatty acid esters (e.g., sucrose fatty acid esters, maltose fatty acid esters, lactose fatty acid esters), propylene glycol fatty acid esters, glycerol fatty acid esters, sorbitan fatty acid esters, polyglycerol fatty acid esters, monoglyceride organic acid esters], etc.

[0049] When using emulsifiers, the ratio (concentration) of the emulsifier in the composition can be selected according to the state and purpose of the composition, and there is no particular limitation. For example, it can be selected from a range of about 40% by mass or less (e.g., 35% by mass or less), such as 30% by mass or less (e.g., 25% by mass or less), preferably 20% by mass or less (e.g., 15% by mass or less), and even more preferably 10% by mass or less (e.g., 8% by mass or less), 5% by mass or less (e.g., 4% by mass or less, 3% by mass or less, 1% by mass or less, etc.).

[0050] The lower limit of the emulsifier ratio (concentration) can be selected according to the state and use of the composition, and there is no particular limitation. For example, it can be 0.01% by mass, 0.1% by mass, 0.5% by mass, 0.7% by mass, 1% by mass, 1.2% by mass, 1.5% by mass, 2% by mass, 3% by mass, etc.

[0051] Emulsifiers can significantly reduce interfacial tension in a composition. Therefore, when the composition is used as the contents of capsules (e.g., seamless capsules manufactured by a dripping method), encapsulation is easily suppressed. From this perspective, when the composition is used as the contents of capsules, it is ideal not to use emulsifiers (virtually not at all), and even when emulsifiers are used, their proportion is ideally relatively small (e.g., 5% by mass or less, 3% by mass or less, etc.).

[0052] The composition may also contain at least one component selected from dicarboxylic acid esters, diol esters, monocarboxylic acid esters, polyol esters having three or more hydroxyl groups, polycarboxylic acid esters having three or more carboxyl groups, polyol ethers, polyamines, and alcohols having six or more carbon atoms (hereinafter, such components are referred to as component (X)).

[0053] In addition to functioning as a medium (solvent, carrier), this component (X) generally performs well in terms of menthol solubility and the antifreeze properties of menthol or oils themselves. In particular, this component (X) can further enhance the solubility of menthol and the antifreeze properties of menthol or oils themselves by combining with eugenol.

[0054] From this perspective, a portion of eugenol can be substituted for component (X) (eugenol and component (X) can be used together). Furthermore, even if this component (X) is included, encapsulation can be performed without significant hindrance in most cases.

[0055] Furthermore, component (X) may be in liquid or solid form at room temperature or room temperature (e.g., 15~35°C).

[0056] The solid component (X) is in liquid form in most cases in the composition at room temperature or room temperature (e.g., dissolved in liquid component (X) or other components).

[0057] In particular, component (X) contains at least one component that is liquid at room temperature or room temperature. In a representative sense, component (X) (when there are two or more components (X), all components (X)) are liquid at room temperature or room temperature.

[0058] Furthermore, component (X) may also have the same function as the other components (carriers, etc.) mentioned above.

[0059] The following will describe them in detail.

[0060] <Dicarboxylic acid ester> Dicarboxylic acid esters are esters of dicarboxylic acids. Such dicarboxylic acid esters can be either monoesters (half-esters) or diesters, especially dicarboxylic acid diesters. This type of dicarboxylic acid diester is usually an ester of one molecule of dicarboxylic acid and two molecules of alcohol. The two alcohol molecules can be the same or different molecules, but usually they are the same molecules.

[0061] There are no particular limitations on dicarboxylic acids; examples include aliphatic dicarboxylic acids and aromatic dicarboxylic acids. Aliphatic dicarboxylic acids can be either saturated or unsaturated. Furthermore, aliphatic dicarboxylic acids can be chain-like (including branched chains) or cyclic. Moreover, dicarboxylic acids can also be hydroxycarboxylic acids, etc. Specific dicarboxylic acids include, for example, aliphatic dicarboxylic acids [e.g., saturated dicarboxylic acids (e.g., oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, octanoic acid, azelaic acid, sebacic acid, cyclohexanedicarboxylic acid, etc., C2-20 saturated dicarboxylic acids, preferably C2-16 saturated dicarboxylic acids, and even more preferably C4-12 saturated dicarboxylic acids), unsaturated dicarboxylic acids (e.g., fumaric acid, maleic acid, cyclohexenedicarboxylic acid, etc., C4-20 unsaturated dicarboxylic acids, preferably C2-16 unsaturated dicarboxylic acids, and even more preferably C4-12 unsaturated dicarboxylic acids)], aromatic dicarboxylic acids [e.g., phthalic acid, isophthalic acid, terephthalic acid, etc., C8-20 aromatic dicarboxylic acids, preferably C8-16 aromatic dicarboxylic acids, and even more preferably C8-12 aromatic dicarboxylic acids], etc.

[0062] Furthermore, there are no particular limitations on alcohols; examples include aliphatic alcohols (including aromatic aliphatic alcohols) and aromatic alcohols. Alcohols can be saturated or unsaturated. Also, alcohols can be chain-like (including branched chains) or cyclic. Alcohols can be monohydric or polyhydric, but are usually monohydric.

[0063] As a specific alcohol (monohydric alcohol), it includes, for example, aliphatic alcohols [such as alkanols (e.g., methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tributanol, pentanol, hexanol, heptanol, octanol, 2-ethylhexanol, decanol, dodecanol, cyclohexanol, etc., C1-20 alkanols, preferably C1-12 alkanols, and even more preferably C1-6 alkanols (e.g., C1-4 alkanols)), aryl alkanols (e.g., benzyl alcohol, phenylethanol, etc., hydroxyl C1-4 alkyl C6-10 aromatic hydrocarbons, etc.)] and so on.

[0064] Dicarboxylic acid esters include all combinations of esters such as dicarboxylic acid esters. Specific examples of dicarboxylic acid diesters include: aliphatic dicarboxylic acid diesters {e.g., saturated dicarboxylic acid diesters [e.g., diethyl malonate, dimethyl succinate, diethyl succinate, diethyl glutarate, diisobutyl adipate, dipropyl adipate, diethyl heptaate, diethyl octanoate, diethyl azelaate, diethyl sebacate, etc., C2-20 saturated dicarboxylic acid diesters (e.g., dialkyl esters (e.g., C1-10 alkyl esters, C1-6 alkyl esters) etc., diesters with aliphatic alcohols) etc.], unsaturated dicarboxylic acid diesters [e.g., diethyl fumarate etc., saturated C4-20 saturated dicarboxylic acid diesters (e.g., diesters with aliphatic alcohols) etc.], aromatic dicarboxylic acid esters [e.g., diethyl phthalate etc., C8-20 aromatic dicarboxylic acid diesters (e.g., dialkyl esters etc., diesters with aliphatic alcohols) etc.], etc.

[0065] Among these dicarboxylic acid esters, aliphatic dicarboxylic acid diesters are particularly desirable. From the perspective of aroma, diesters of saturated or unsaturated dicarboxylic acids with 4 or more carbon atoms are even more desirable (e.g., diethyl succinate, diethyl sebacate, diisobutyl adipate, diethyl fumarate, etc., C4-20 saturated or unsaturated dicarboxylic acid diesters).

[0066] Dicarboxylic acid diesters can be used alone or in combination of two or more.

[0067] <Diol Ester> Diol esters are esters of diols. Such diol esters can be either monoesters or diesters, and in particular, they can be diol diesters. This type of glycol diester is typically an ester of one molecule of glycol and two molecules of carboxylic acid. The two carboxylic acid molecules can be the same or different molecules, but usually they are the same molecule.

[0068] There are no particular limitations on the type of diol; examples include aliphatic diols (including aromatic aliphatic diols) and aromatic diols. Aliphatic diols can be either saturated or unsaturated. Furthermore, aliphatic diols can be chain-like (including branched chains) or cyclic.

[0069] As a specific diol, it includes, for example, aliphatic diols [e.g., alkyl diols (e.g., ethylene glycol, 1,3-propanediol, 1,2-propanediol, 1,4-butanediol, 1,3-butanediol, pentanediol, hexanediol, heptanediol, octanediol, decanediol, dodecanediol, cyclohexanediol, cyclohexanediol, etc., C2-20 alkyl diols, preferably C2-16 alkyl diols, and even more preferably C2-12 alcohols), polyalkyl diols (e.g., diethylene glycol, dipropylene glycol, triethylene glycol, etc., two to six C2-6 alkyl diols), hydroxyalkyl aromatics (e.g., di(hydroxyC1-4alkyl)C6-10 aromatics, etc., such as benzenedimethylol) etc.] etc.

[0070] Furthermore, there are no particular limitations on carboxylic acids; examples include aliphatic carboxylic acids (including aromatic aliphatic carboxylic acids) and aromatic carboxylic acids. Carboxylic acids can be saturated or unsaturated. They can also be chain-like (including branched chains) or cyclic. Moreover, carboxylic acids can also be hydroxycarboxylic acids, etc. Furthermore, a carboxylic acid can be either a monocarboxylic acid or a polycarboxylic acid; typically, it can be a monocarboxylic acid.

[0071] Specific carboxylic acids include, for example, aliphatic carboxylic acids (such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid, isovaleric acid, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, pearlitic acid, stearic acid, oleic acid, cyclohexane carboxylic acid, etc., C1-30 aliphatic carboxylic acids, preferably C1-12 aliphatic carboxylic acids, and even more preferably C1-6 aliphatic carboxylic acids), aromatic carboxylic acids (such as benzoic acid, salicylic acid, etc., carboxyl C6-10 aromatic hydrocarbons, etc.) and other monocarboxylic acids.

[0072] As a diol ester, it includes all combinations of esters such as diol esters. Specific examples of diol esters include: aliphatic diol esters [such as ethylene glycol diacetate, propylene glycol diacetate, 1,4-butanediol diacetate, butylene glycol diacetate, 1,6-hexanediol diacetate, 1,8-octanediol diacetate, ethylene glycol bis(butyrate), triethylene glycol dibutyrate, etc., C2-20 aliphatic diol-diesters (e.g., diesters with aliphatic carboxylic acids)] and other diol esters.

[0073] In particular, from the perspective of menthol solubility, diesters of aliphatic diols with 3 or more carbon atoms (such as C3-20 aliphatic diols, C4-16 aliphatic diols, C6-12 aliphatic diols, etc.) (such as diesters with aliphatic carboxylic acids) are suitable.

[0074] Diol esters can be used alone or in combination of two or more.

[0075] Monocarboxylic esters Monocarboxylic acid esters (monocarboxylic acid monoesters) are esters of monocarboxylic acids (esters of monocarboxylic acids and alcohols, or esters of one molecule of alcohol and one molecule of carboxylic acid). The alcohol can be either a monohydric alcohol or a polyhydric alcohol, but is usually a monohydric alcohol.

[0076] There are no particular limitations on monocarboxylic acids; examples include aliphatic carboxylic acids (including aromatic aliphatic carboxylic acids) and aromatic carboxylic acids. Carboxylic acids can be saturated or unsaturated. Furthermore, carboxylic acids can be chain-like (including branched chains) or cyclic. Moreover, carboxylic acids can also be hydroxycarboxylic acids, etc.

[0077] Specific monocarboxylic acids include, for example, aliphatic carboxylic acids [such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid, isovaleric acid, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, pearlitic acid, stearic acid, oleic acid, linolenic acid, linolenic acid, cyclohexanecarboxylic acid, etc., C1-30 aliphatic carboxylic acids, preferably C4-28 aliphatic carboxylic acids, and even more preferably C6-24 aliphatic carboxylic acids (e.g. aliphatic carboxylic acids with 14 or fewer carbon atoms)], aromatic carboxylic acids (e.g., benzoic acid, salicylic acid, etc., carboxyl C6-10 aromatic hydrocarbons)], etc.

[0078] As an alcohol, there are no particular limitations; examples include aliphatic alcohols (including aromatic aliphatic alcohols) and aromatic alcohols. Alcohols can be saturated or unsaturated. Furthermore, alcohols can be chain-like (including branched chains) or cyclic.

[0079] As specific alcohols (monohydric alcohols), they include, for example, aliphatic alcohols [e.g., alkanols (e.g., methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tributanol, pentanol, hexanol, heptanol, octanol, 2-ethylhexanol, decanol, dodecanol, cyclohexanol, etc., C1-20 alkanols, preferably C1-12 alkanols, and even more preferably C1-6 alkanols (e.g., C1-4 alkanols)), aryl alkanols (e.g., benzyl alcohol, phenylethanol, etc., hydroxyl C1-4 alkyl C6-10 aromatics, etc.)] etc.

[0080] As a monocarboxylic acid ester, it includes all combinations of esters such as those mentioned above. Specific examples of monocarboxylic acid esters include: aliphatic carboxylic acid esters [aliphatic monocarboxylic acid esters (monoesters), such as ethyl decanoate, ethyl laurate, ethyl palmitate, etc., esters of C1-30 aliphatic carboxylic acids (e.g., C4-28 aliphatic carboxylic acids, C6-24 aliphatic carboxylic acids) (e.g., esters with aliphatic alcohols)], aromatic carboxylic acid esters [aromatic monocarboxylic acid esters (monoesters), such as benzyl benzoate, benzyl salicylate, etc., C7-20 aromatic carboxylic acid esters], etc.

[0081] Monocarboxylic acid esters can be used alone or in combination of two or more.

[0082] <Esters of polyols containing three or more hydroxyl groups> Esters of polyols having three or more hydroxyl groups can be either partial esters (e.g., monoesters, diesters) or full esters (e.g., triesters when the alcohol is a triol). Typically, they can be full esters. Furthermore, these esters are usually not classified as fats or oils (MCTs, etc.).

[0083] In cases where the ester of a polyol having three or more hydroxyl groups is an ester of two or more carboxylic acid molecules, the carboxylic acid molecules can be the same or different molecules; representatively, they can be the same molecules.

[0084] There is no particular limitation on polyols having three or more hydroxyl groups. Examples include aliphatic polyols (including aromatic aliphatic polyols) and aromatic polyols. Polyols having three or more hydroxyl groups (aliphatic polyols) can be either saturated or unsaturated. Furthermore, polyols having three or more hydroxyl groups (aliphatic polyols) can be chain-like (including branched) or cyclic.

[0085] In polyols having three or more hydroxyl groups, the number of hydroxyl groups only needs to be three or more, for example, 3 to 10, preferably 3 to 6, and even more preferably 3 to 5 (e.g., 3).

[0086] Specifically, polyols having three or more hydroxyl groups include, for example, aliphatic polyols {e.g., alkyltrihexaols [e.g., alkyltriols (e.g., glycerol, 1,2,4-butanetriol, trimethylolpropane, trimethylolpropane, etc., C3-10 alkyltriols), alkyltetraols (e.g., butanetetrol, pentaerythritol, etc., C3-10 alkyltetraols)], polyalkyl polyols [e.g., diglycerol, di-trimethylolpropane, dipentaerythritol, etc., poly(alkyltrihexaols)], etc.}, etc.

[0087] Furthermore, there are no particular limitations on carboxylic acids; examples include aliphatic carboxylic acids (including aromatic aliphatic carboxylic acids) and aromatic carboxylic acids. Carboxylic acids can be saturated or unsaturated. They can also be chain-like (including branched chains) or cyclic. Moreover, carboxylic acids can also be hydroxycarboxylic acids, etc. Furthermore, a carboxylic acid can be either a monocarboxylic acid or a polycarboxylic acid; typically, it can be a monocarboxylic acid.

[0088] Specific carboxylic acids (monocarboxylic acids) include, for example, aliphatic carboxylic acids (such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid, isovaleric acid, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, pearlitic acid, stearic acid, oleic acid, cyclohexane carboxylic acid, etc., C1-30 aliphatic carboxylic acids, preferably C1-12 aliphatic carboxylic acids, and even more preferably C1-6 aliphatic carboxylic acids), aromatic carboxylic acids (such as benzoic acid, salicylic acid, etc., carboxyl C6-10 aromatic hydrocarbons, etc.), etc.

[0089] Esters of polyols having three or more hydroxyl groups, including all combinations thereof. Specifically, esters of polyols having three or more hydroxyl groups include, for example, triol esters {e.g., triol triesters [e.g., triglyceride triazolic acid (fatty acid) triesters of glycerol (e.g., triglyceride tributyrate and other triesters of glycerol with 6 or fewer carbon atoms (e.g., 5 or fewer, 4 or fewer) of fatty acids (e.g., three C 1-6 fatty acid esters, three C 1-5 fatty acid esters, three C 1-4 fatty acid esters, etc.)] etc.} etc.

[0090] Polyol esters with three or more hydroxyl groups can be used alone or in combination of two or more.

[0091] <Esters of polycarboxylic acids having three or more carboxyl groups> Esters of polycarboxylic acids having three or more carboxyl groups can be either partial esters (e.g., monoesters, diesters) or full esters (e.g., triesters when the polycarboxylic acid is a tricarboxylic acid). Typically, they can be full esters.

[0092] When a polycarboxylic acid ester with three or more carboxyl groups is an ester of two or more alcohol molecules, the alcohol molecules can be the same or different molecules; typically, they can be the same molecules.

[0093] There is no particular limitation on polycarboxylic acids having three or more carboxyl groups. Examples include aliphatic polycarboxylic acids (including aromatic aliphatic polycarboxylic acids). Polycarboxylic acids having three or more carboxyl groups can be saturated, unsaturated, or aromatic. Furthermore, polycarboxylic acids having three or more carboxyl groups can be chain-like (including branched) or cyclic.

[0094] In polycarboxylic acids having three or more carboxyl groups, the number of carboxyl groups only needs to be three or more, for example, 3 to 10, preferably 3 to 6, and even more preferably 3 to 5 (e.g., 3).

[0095] Specifically, polycarboxylic acids having three or more carboxyl groups include, for example, aliphatic polycarboxylic acids {e.g., aliphatic tri- to hexacarboxylic acids [e.g., aliphatic tricarboxylic acids (e.g., citric acid, aconitic acid, etc., C5-12 aliphatic tricarboxylic acids), etc., poly(aliphatic tri- to hexacarboxylic acids) etc.] etc.} etc.

[0096] As an alcohol, there are no particular limitations; examples include aliphatic alcohols (including aromatic aliphatic alcohols) and aromatic alcohols. Alcohols can be saturated or unsaturated. Furthermore, alcohols can be chain-like (including branched-chain) or cyclic. Alcohols can be monohydric or polyhydric, but are usually monohydric.

[0097] As a specific alcohol (monohydric alcohol), it includes, for example: aliphatic alcohols [e.g., alkanols (e.g., methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tert-butanol, pentanol, hexanol, heptanol, octanol, 2-ethylhexanol, decanol, dodecanol, cyclohexanol, etc., C1-20 alkanols, preferably C1-12 alkanols, and even more preferably C1-6 alkanols (e.g., C1-4 alkanols)), aryl alkanols (e.g., benzyl alcohol, phenylethanol, etc., hydroxyl C1-4 alkyl C6-10 aromatic hydrocarbons, etc.) etc.].

[0098] Esters of polycarboxylic acids having three or more carboxyl groups, including all combinations thereof. Specifically, esters of polycarboxylic acids having three or more carboxyl groups include, for example, tricarboxylic acid esters {e.g., tricitrate [e.g., aliphatic alcohol triesters of citric acid (e.g., triethyl citrate and other tri-C1-6 alkyl esters of citrate)], etc.}, etc.

[0099] <Polyol Ethers> Polyol ethers can be either partial ethers (e.g., monoethers) or complete ethers (e.g., diethers when the polyol is a diol). Typically, they can be complete ethers. When such a polyol ether is an ether of two or more alcohol molecules, the alcohol molecules can be the same or different molecules; typically, they can be the same molecules.

[0100] There are no particular limitations on polyols; examples include aliphatic polyols (including aromatic aliphatic polyols) and aromatic polyols. Aliphatic polyols can be either saturated or unsaturated. Furthermore, aliphatic polyols can be chain-like (including branched-chain) or cyclic.

[0101] In polyols, the number of hydroxyl groups only needs to be 2 or more, for example, 2 to 10, preferably 2 to 6, and even more preferably 2 to 4 (e.g., 2).

[0102] Specific examples of polyols include diols and polyols with three or more hydroxyl groups.

[0103] As diols, they include, for example, aliphatic diols [e.g., alkyl diols (e.g., ethylene glycol, 1,3-propanediol, propylene glycol, 1,4-butanediol, butanediol, pentanediol, hexanediol, heptanediol, octanediol, decanediol, dodecanediol, cyclohexanediol, cyclohexanediethanol, etc., C2-20 alkyl diols, preferably C2-16 alkyl diols, and even more preferably C2-12 alcohols), polyalkyl diols (e.g., diethylene glycol, dipropylene glycol, triethylene glycol, etc., two to six C2-6 alkyl diols), dihydroxyalkyl aromatics (e.g., di(hydroxyC1-4alkyl)C6-10 aromatics, etc., such as benzenediethanol), etc.] etc.

[0104] Polyols having three or more hydroxyl groups include, for example, aliphatic polyols {e.g., alkyltrihexaols [e.g., alkyltriols (e.g., glycerol, 1,2,4-butanetriol, trimethylolpropane, trimethylolpropane, etc., C3-10 alkyltriols), alkyltetraols (e.g., butanetetrol, pentaerythritol, etc., C3-10 alkyltetraols)], polyalkyl polyols [e.g., diglycerol, di-trimethylolpropane, dipentaerythritol, etc., poly(alkyltrihexaols)], etc.}, etc.

[0105] Furthermore, there are no particular limitations on the alcohols that constitute the ether group; examples include aliphatic alcohols (including aromatic aliphatic alcohols) and aromatic alcohols. Alcohols can be saturated or unsaturated. Also, alcohols can be chain-like (including branched chains) or cyclic. Alcohols can be monohydric or polyhydric, but are usually monohydric.

[0106] As specific alcohols (monohydric alcohols), they include, for example, aliphatic alcohols [e.g., alkanols (e.g., methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tributanol, pentanol, hexanol, heptanol, octanol, 2-ethylhexanol, decanol, dodecanol, cyclohexanol, etc., C1-20 alkanols, preferably C1-12 alkanols, and even more preferably C1-6 alkanols (e.g., C1-4 alkanols)), aryl alkanols (e.g., benzyl alcohol, phenylethanol, etc., hydroxyl C1-4 alkyl C6-10 aromatics, etc.) etc.] etc.

[0107] As a polyol ether, it includes all combinations thereof. Specific examples of polyol ethers include: aliphatic polyol ethers {e.g., aliphatic diol ethers [e.g., 1,2-diethoxyethane, ethylene glycol dibutyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, etc., C2-20 aliphatic diol-ethers (e.g., alkyl ethers (e.g., C1-10 alkyl ethers, C1-6 alkyl ethers, etc., mono- or di-ethers with aliphatic alcohols)] etc.} etc.

[0108] Polyol ethers can be used alone or in combination of two or more.

[0109] <Polyamine> In polyamine, the number of amine groups (nitrogen atoms) only needs to be 2 or more, for example, 2 to 10, preferably 2 to 6, and even more preferably 2 to 4 (e.g., 2).

[0110] Polyamine is not particularly limited and can be any type of aliphatic polyamine (including aromatic aliphatic polyamine) or aromatic polyamine. Aliphatic polyamine can be either saturated or unsaturated. Furthermore, aliphatic polyamine can be chain-like (including branched) or cyclic.

[0111] The amino group can also be a substituted amino group. Among the substituted amino groups, examples of substituents include: hydrocarbon groups [such as alkyl groups (e.g., methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tributyl, hexyl, 2-ethylhexyl, etc., C1-10 alkyl groups)].

[0112] A substituted amino group can be formed simply by replacing one or both of the two hydrogen atoms that make up the amino group.

[0113] Specific examples of polyamines include: polyamines (N-unsubstituted polyamines) [e.g., diamines (e.g., ethylenediamine, butanediamine, pentanediamine, 1,6-hexanediamine, etc., C1-10 alkyldiamines)], N-substituted polyamines [e.g., N-substituted diamines (e.g., N,N'-diethyl-1,6-hexanediamine, etc., N-mono-tetraalkyl (e.g., C1-4 alkyl)-C1-10 alkyldiamines)], etc.

[0114] Polyamines can be used alone or in combination of two or more types.

[0115] Alcohols with 6 or more carbon atoms There are no particular limitations on alcohols with 6 or more carbon atoms; examples include aliphatic alcohols (including aromatic aliphatic alcohols) and aromatic alcohols. Aliphatic alcohols are a representative example. Aliphatic alcohols can be either saturated or unsaturated. Furthermore, aliphatic alcohols can be chain-like (including branched chains) or cyclic; typically, they can be chain-like.

[0116] Furthermore, alcohols with 6 or more carbon atoms can be either monohydric or polyhydric, but are usually monohydric.

[0117] Furthermore, alcohols with 6 or more carbon atoms can be primary, secondary, or tertiary alcohols; typically, they can be primary alcohols.

[0118] Specifically, alcohols (monohydric alcohols) having 6 or more carbon atoms include, for example, aliphatic alcohols [e.g., alkanols (e.g., hexanol, heptanol, octanol, 2-ethylhexanol, nonanol, decanol, undecanol, dodecanol, tridecanol, tetradecanol, pentadecanol, hexadecanol, etc., C6-30 alkanols, preferably C8-18 alkanols, and even more preferably C10-16 alkanols), aryl alkanols (e.g., benzyl alcohol, phenylethanol, etc., hydroxyl C1-4 alkyl C6-10 aromatic hydrocarbons, etc.)] etc.

[0119] Representative examples of alcohols with 6 or more carbon atoms include C10-16 alcohols (C10~C16 alcohols). C10~C16 alcohols are alcohols with 10 to 16 carbon atoms (e.g., straight-chain primary alcohols). Examples of alcohols with 6 or more carbon atoms include: C10-C16 alcohols [e.g., 1-decyl alcohol, 1-undecyl alcohol, 1-dodecyl alcohol, 1-tridecyl alcohol, 1-tetradecyl alcohol, 1-pentadecanyl alcohol, 1-hexadecyl alcohol, etc. (especially straight-chain primary alcohols)] and aryl alcohols (e.g., benzyl alcohol). While 1-decyl alcohol and benzyl alcohol have higher solubility for menthol, their addition may produce a slightly off-odor compared to other alcohols with 6 or more carbon atoms, but this also depends on the amount added. On the other hand, while 1-tridecyl alcohol, 1-tetradecyl alcohol, 1-pentadecanyl alcohol, and 1-hexadecyl alcohol are odorless, their solubility for menthol is lower than that of alcohols with fewer carbon atoms, but this also depends on the amount added.

[0120] When using alcohols with 6 or more carbon atoms, these factors should be considered, and an appropriate selection can be made based on the intended use. For example, regarding benzyl alcohol, from an aroma perspective, by reducing the amount blended or combining it with other ingredients (X) (such as dicarboxylic acid diesters) or other ingredients (MCT), a good balance can be achieved between the solubility and aroma of menthol. On the other hand, 1-dodecanool and similar alcohols are considered particularly ideal compared to other alcohols with 6 or more carbon atoms because they have no odor and higher menthol solubility.

[0121] Alcohols with 6 or more carbon atoms can be used alone or in combination of two or more.

[0122] Furthermore, alcohols with 6 or more carbon atoms (such as C10-16 alcohols) can also be used in combination with other components (X) or MCTs, etc. By using such combinations, compositions that are beneficial to the solubility of menthol and the balance of aroma can be formed.

[0123] Especially when combining alcohols with 6 or more carbon atoms with other components (X) (such as dicarboxylic acid esters), the ratio can be selected according to the desired solubility of menthol or whether the aroma needs to be maintained. For example, the ratio of alcohols with 6 or more carbon atoms relative to the total amount of alcohols with 6 or more carbon atoms and other components (X) can be 1 to 99% by mass (e.g., 2 to 98% by mass), preferably 5 to 95% by mass (e.g., 10 to 90% by mass), or more than 5% by mass, 10% by mass, 15% by mass, 20% by mass, 30% by mass, 40% by mass, 50% by mass, less than 95% by mass, less than 90% by mass, less than 85% by mass, less than 80% by mass, less than 75% by mass, less than 70% by mass, less than 60% by mass, less than 50% by mass, etc.

[0124] Ingredient (X) can be used alone or in combination of two or more.

[0125] Among these ingredients (X), in terms of the solubility of menthol, dicarboxylic acid esters (e.g., aliphatic dicarboxylic acid diesters, etc.), diol esters (e.g., diesters of aliphatic diols with 3 or more carbon atoms, etc.), monocarboxylic acid esters (e.g., aliphatic monocarboxylic acid esters of C6-24 aliphatic carboxylic acids, etc.), esters of polyols having 3 or more hydroxyl groups (e.g., triol triesters of aliphatic triols, such as C1-6 fatty acid esters, etc.), polyol ethers (e.g., diol diethers of aliphatic diols (dialkyl ethers, etc.), etc.), polyamines (e.g., diamines of N-alkyl substituted diamines (e.g., N,N'-dialkyl diamines), etc.), alcohols with 6 or more carbon atoms (e.g., C10-16 alkanols (e.g., straight-chain alkanols such as 1-decanol, 1-dodecanol, 1-hexadecanol), aryl alcohols (e.g., benzyl alcohol), etc.) are suitable.

[0126] Furthermore, in terms of resistance to freezing, dicarboxylic acid esters (such as aliphatic dicarboxylic acid diesters and other dicarboxylic acid diesters), monocarboxylic acid esters [such as aromatic monocarboxylic acid esters (monoesters), such as benzyl benzoate, benzyl salicylate and other C7-20 aromatic carboxylic acid esters] are suitable.

[0127] Among these components (X), from the viewpoint of menthol's solubility or antifreeze properties and the balance between aroma maintenance, dicarboxylic acid esters (such as aliphatic dicarboxylic acid diesters with 4 or more carbon atoms) are suitable.

[0128] Therefore, component (X) may contain at least this component (compound).

[0129] When using component (X), the ratio (concentration) of component (X) in the composition can be selected depending on the state of the composition, the type of component (X) selected, and its intended use, and there is no particular limitation. It can generally be selected from a range of approximately 99% by mass or less (e.g., 97% by mass or less), for example, 95% by mass or less (e.g., 90% by mass or less), 85% by mass or less (e.g., 80% by mass or less), 75% by mass or less (e.g., 70% by mass or less), or 65% by mass or less (e.g., 60% by mass or less, 55% by mass or less). (The following are acceptable values: below 50% by mass, below 45% by mass, below 40% by mass, below 35% by mass, below 30% by mass, below 25% by mass, below 20% by mass, etc.), or above 1% by mass, above 2% by mass, above 3% by mass, above 4% by mass, above 5% by mass, above 6% by mass, above 7% by mass, above 8% by mass, above 9% by mass, above 10% by mass, above 12% by mass, above 15% by mass, above 18% by mass, above 20% by mass, above 22% by mass, above 25% by mass, etc.

[0130] The range of the ratio (concentration) of component (X) can be set by appropriately combining the upper and lower limits of the above range (e.g., 1~85% by mass, 5~50% by mass, 10~35% by mass, etc.) as described above.

[0131] The ratio (concentration) of component (X) relative to the total amount (total measure) of eugenol and component (X) [when the total amount is set to 100% by mass] can also be selected from the concentration range of component (X) in the above composition (e.g., 99% by mass or less, 90% by mass or less, 1 to 80% by mass, 3 to 70% by mass, 5 to 60% by mass, etc.).

[0132] The ratio (concentration) of component (X) relative to the total amount (total measure) of menthol and component (X) [when the total amount is set to 100% by mass] can also be selected from the concentration range of component (X) in the above composition (e.g., 99% by mass or less, 90% by mass or less, 1 to 80% by mass, 3 to 70% by mass, 5 to 60% by mass, etc.).

[0133] Furthermore, when the composition contains oils, the ratio (concentration) of component (X) relative to the total amount (total) of oils and component (X) [when the total amount is set to 100% by mass] can also be selected from the concentration range of component (X) in the above composition (e.g., 99% by mass or less, 90% by mass or less, 1 to 80% by mass, 3 to 70% by mass, 5 to 60% by mass, etc.).

[0134] [Composition] The composition can be in the form of a solid, a liquid, or a liquid, especially a liquid. Furthermore, liquids also include colloidal, emulsion, and jelly-like forms.

[0135] The composition may also be formulated appropriately depending on the intended use and the form of administration. There are no particular limitations on the form (dosage form, properties) of such a composition (formulation), and examples include: tablets, powders, granules, pellets, dry syrups, coated tablets, intraorally disintegrating tablets, chewable tablets, capsules, soft capsules, syrups, oral liquids, lozenges, gels, inhalers, suppositories, injections, ointments, eye drops, eye ointments, nasal drops, ear drops, dressings, lotions, external liquids, sprays, external mists, creams, gels, patches, buccal tablets, sublingual tablets, liquids, suspensions, emulsions, liniments, tablets, etc. Furthermore, the composition can also be a pharmaceutical product (pharmaceutical, pharmaceutical composition).

[0136] When ingesting the combination (or eugenol and menthol), there are no particular limitations on the form of administration (or administration). It can be administered orally or non-orally. Examples of non-oral administration include: administration via the lungs, nose, skin, mucous membranes (e.g., oral mucosal administration), eye drops, ear drops, and injection (subcutaneous, intramuscular, intravenous, etc.). These forms of administration can be used alone or in combination of two or more.

[0137] Representative forms of intake include oral, pulmonary, and dermal administration. In particular, when it comes to the intake of eugenol, pulmonary intake is considered the preferred form. Pulmonary intake (inhalation, etc.) allows for highly efficient absorption of eugenol. Therefore, pulmonary intake is the preferred form of intake.

[0138] Furthermore, the form of intake can be appropriately selected according to the purpose and use of intake. For example, by taking it through the lungs, the function of eugenol can be easily and efficiently exerted (advantageously) by taking it for at least one purpose (function, use) selected from (1) to (3) below.

[0139] The intake (dosage, administration) of the composition can be selected according to the intended use, function and administration form (and thus age, gender, weight, etc.), and there are no particular limitations.

[0140] For example, for the composition, eugenol can be ingested at a rate of 0.01 mg or more, 0.05 mg or more, or 0.1 mg or more (calculated as eugenol) each time.

[0141] In a specific form, for the composition, eugenol can be inhaled via the lungs at a rate of, for example, 0.1 mg / min or more (based on eugenol).

[0142] Furthermore, the inhalation volume (drawing volume) of the composition (containing eugenol vapor or gas) per instance may be, for example, more than 10 mL, more than 20 mL, more than 30 mL, or less than 4500 mL, less than 4000 mL, less than 3000 mL, less than 2000 mL, less than 1000 mL, less than 500 mL, etc.

[0143] As in other specific forms (e.g., for use in chewing tobacco), for the composition, eugenol can be ingested orally at a rate of, for example, 1 mg or more per dose (calculated as eugenol).

[0144] Furthermore, the frequency of intake of the composition (eugenol) (e.g., the number of times per day) can be selected according to the intake form or the required function, and can be taken once or in multiple doses. The composition can be ingested by humans, non-humans (or animals). Non-human animals can be pets (dogs, cats, etc.). Furthermore, when the composition contains menthol, the menthol uptake state can also be the same as that of eugenol as described above.

[0145] As described above, the composition can be appropriately formulated and applied to various uses. Specific examples of use include: capsules (e.g., capsule contents), filters, cigarettes, inhalation devices, etc.

[0146] The following are examples of their usage.

[0147] <Capsule> Capsules may consist of only a membrane, or they may consist of a membrane and contents (core). In particular, in cigarette capsules, the capsule may consist of a core (contents, liquid contents, encapsulating material) and an outer shell (membrane, coating, capsule coating).

[0148] Capsules can be soft capsules, hard capsules, or seamless capsules. In particular, for capsules used in cigarettes, seamless capsules (capsules without seams) are acceptable.

[0149] In the capsule, the form in which the composition (eugenol, menthol, oil, component (X), etc.) is contained is not particularly limited; it may be a membrane, a core, or both. In particular, for capsules with a core (seamless capsules), the core (or at least the core) may contain the composition. In other words, this state can be referred to as the state of using the composition of the present invention in the contents of a capsule.

[0150] The capsule shell typically contains film-forming components (film-forming base, film-forming agent). There are no particular limitations on the film-forming components; they can be appropriately selected based on the intended use of the capsule. Examples include: polysaccharides (or their derivatives) {e.g., polysaccharides from seaweed [e.g., agar, carrageenan, alginic acid or their salts (e.g., alkali metal salts (sodium, potassium, etc.), alkaline earth metal salts (calcium, magnesium, etc.), iron, tin, etc.), red algae gum, cardamom, etc.], polysaccharides from resins (e.g., gum arabic, gum arabic, etc.), polysaccharides from microorganisms (e.g., polydextrose, guar gum, gellan gum, etc.), and polysaccharides from plants (e.g., astragalus gum, pectin, glucomannan, starch, polydextrose, dextrin, maltodextrin, cyclodextrin, etc.]} Indigestible dextrins, etc.), polysaccharides from seeds [e.g., guar gum or its derivatives (e.g., hydroxypropyl guar gum, cationic guar gum, guar gum decomposition products (guar gum enzyme decomposition products, etc.)], tara gum, tamarind gum, locust bean gum, psyllium husk gum, flaxseed gum, etc.], fermented polysaccharides (e.g., dextrin, etc.), cellulose derivatives (e.g., hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, carboxymethyl cellulose, etc.), polyglucosamine, etc.], synthetic resins (e.g., polyvinyl alcohol), proteins (e.g., gelatin, casein, corn protein, etc.), sugar alcohols (e.g., sorbitol, maltitol, lactitol, barbitol, xylitol, mannitol, galactitol, butyltetrafluoroethylene, etc.). The film-forming ingredients can be used alone or in combination of two or more.

[0151] Furthermore, film-forming components can form hydrophilic colloids, and depending on their type, they can also function as plasticizers, sweeteners, dietary fibers, and extenders. Moreover, commercially available film-forming components are also available.

[0152] The film may also contain plasticizers, colorants, sweeteners, flavorings, antioxidants, preservatives, etc.

[0153] For example, the film may also contain plasticizers to adjust the strength of the film. Examples of plasticizers include: polyols (e.g., ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, etc.; polyols with three or more hydroxyl groups such as glycerol), sugars (e.g., monosaccharides such as glucose, fructose, glucose, galactose, etc.), disaccharides (e.g., sucrose, maltose, trehalose, coupled sugars, etc.), oligosaccharides (e.g., maltodextrin, etc.), sugar alcohols (e.g., sorbitol, maltitol, lactitol, barbiturate, xylitol, mannitol, galactitol, butyltetrafluoroethylene, etc.), polysaccharides or their derivatives (e.g., starch, starch derivatives such as polydextrose, dextrin, maltodextrin, indigestible dextrin, cyclodextrin (α, β, or γ) etc.), cellulose derivatives such as hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, carboxymethyl cellulose, etc.), polyvinyl alcohol, triacetylglycerol, etc. Plasticizers can be used alone or in combination of two or more. Furthermore, sugar alcohols, starch, starch derivatives, etc., can also be used as film-forming components as described above.

[0154] In capsules having a core, the core can be solid, liquid, or in particular, liquid in capsules containing the composition of the present invention. Furthermore, liquid forms also include colloidal, emulsion, and jelly-like forms.

[0155] As mentioned above, the core ingredient is eugenol (and thus menthol and / or oils), and may also contain other ingredients.

[0156] Other examples include the ingredients listed above, such as ingredient (X). Furthermore, in this type of capsule, the core is the composition of the present invention, and the preferred form of the core is as described above.

[0157] The core is usually non-soluble (non-corrosive) to the film (or the part in contact with the film).

[0158] The capsule (or membrane) diameter (average diameter) can be appropriately selected according to the type and purpose of the capsule. For example, it can be 0.1 mm or more, 0.5 mm or more, 1 mm or more, 1.5 mm or more, 2 mm or more, etc., or it can be less than 30 mm, less than 25 mm, less than 20 mm, less than 18 mm, less than 15 mm, less than 12 mm, less than 10 mm, less than 8 mm, etc. Specific capsule diameters include 2.8 mm, 3.0 mm, 3.4 mm, 3.5 mm, 4.0 mm, etc., but are not limited to these values.

[0159] In a capsule containing a core, the membrane percentage (the ratio of the membrane to the total amount of the capsule (the total amount of the membrane and the contents)) can be selected from, for example, in the range of about 0.1 to 99% by mass (e.g., 0.5 to 95% by mass), preferably 1 to 90% by mass, more preferably 1.5 to 80% by mass (e.g., 2 to 70% by mass), and even more preferably about 2.5 to 60% by mass (e.g., 3 to 50% by mass).

[0160] The thickness of the membrane in a capsule with a core is not particularly limited; for example, it can be 1~200 μm, 3~150 μm, 5~100 μm, etc.

[0161] Capsules (e.g., capsules with a core) may also be capable of breaking (disintegration) (e.g., exhibiting disintegration or destructive properties). In such capsules, the strength of the breakdown depends on factors such as capsule diameter, and may be, for example, 100 g or more, 200 g or more, 300 g or more, 400 g or more, 500 g or more, 600 g or more, 700 g or more, 800 g or more, 900 g or more, 1000 g or more, etc. There is no particular limit to the upper limit of the destructive strength of the capsule, such as below 20,000 g, below 15,000 g, below 12,000 g, below 10,000 g, etc. The destructive strength can be measured, for example, using a rheometer CR-3000EX (manufactured by Sun Scientific).

[0162] In capsules (e.g., capsules containing contents), the ratio of breaking strength (g) to outer diameter (mm) (breaking strength / outer diameter) is not particularly limited. For example, it can be 200 or more (e.g., more than 200), preferably 210 or more (e.g., more than 220), and even more preferably 230 or more (e.g., more than 240), or it can be 250 or more, 300 or more, 400 or more, etc. Furthermore, there is no particular upper limit to the ratio of breaking strength to outer diameter (breaking strength / outer diameter), such as 20000, 15000, 10000, 8000, 6000, 5000, etc.

[0163] Assuming there are situations where the capsule is easily damaged even with high destructive strength (e.g., a large outer diameter), it can be said that the ratio of destructive strength to outer diameter is an indicator of the capsule's actual ease of destruction.

[0164] The destruction distance of the capsule depends on the outer diameter, etc., and can be 0.1 mm or more, 0.2 mm or more, 0.5 mm or more, 1.0 mm or more, etc. There is no particular limit to the upper limit of the damage distance of soft capsules; for example, it can be less than 15 mm, less than 10 mm, less than 8 mm, etc. The destructive distance can be measured, for example, using a rheometer CR-3000EX (manufactured by Sun Scientific).

[0165] In the capsule, the ratio of the breaking distance (mm) to the outer diameter (mm) (breaking distance / outer diameter) is not particularly limited. For example, it can be 0.1 or more, preferably 0.12 or more, and even more preferably 0.15 or more, or 0.18 or more, 0.2 or more, etc. There is no particular upper limit to the ratio of the damage distance to the outer diameter (damage distance / outer diameter), for example, it can be 1.0, 0.98, 0.97, 0.96, 0.95, etc.

[0166] Furthermore, the capsules can be used directly depending on the intended use, or in combination with other capsules, or incorporated into filters, etc., as described below.

[0167] Other types of capsules may include capsules that do not contain eugenol, such as capsules consisting of a core and a shell, neither of which contains eugenol.

[0168] The manufacturing method of capsules (e.g., seamless capsules) can utilize known methods. Examples of such manufacturing methods include those described in Japanese Patent No. 5047285, Japanese Patent No. 10-506841, and Japanese Patent No. 5581446. For example, a liquid-to-liquid method using a dripping method based on two or more nozzles can be used. Using this method, the capsule contents are filled into the capsule membrane, and then the membrane is hardened and dried, thereby manufacturing a seamless capsule.

[0169] Furthermore, in addition to applications such as filters, cigarettes, and inhalation devices, capsules can also be used in other applications, such as capsules for health function foods (e.g., foods for specific health purposes, nutritional functional foods, etc.), supplements, and other food and beverage applications.

[0170] <Filter> In filters, the manner in which the composition of the present invention is used is not particularly limited. For example, various parts of the filter (filter material, filter components) may contain (attach) the composition.

[0171] In particular, such filters can be filters containing capsules (filters with capsules or filters composed of filter components with capsules).

[0172] That is, in this kind of filter, a capsule (first capsule) containing a composition (eugenol, menthol, oil, component (X) etc.) is included as the capsule. As the first capsule, the capsules described in the above-mentioned capsule section can be used, and in particular, the capsule (first capsule) is preferably a capsule consisting of a core and a shell, and the core (contents) is a capsule containing the composition of the present invention (the composition of the present invention).

[0173] Furthermore, this type of filter only needs to contain at least a first capsule as a capsule, or it can contain a second capsule that is different from the first capsule.

[0174] As for the second capsule, it can be any capsule that is different from the first capsule. For example, the second capsule can be a capsule containing contents that are different from those of the first capsule.

[0175] Examples of such a second capsule include: a capsule consisting of a core and a shell, wherein the core (and shell) contains at least one of a carrier and a flavoring (especially one that does not contain eugenol).

[0176] Furthermore, the capsules contained in the filter described above may be those described in the capsule section above. Capsules that do not contain eugenol (such as capsule 2) may be those described in the capsule section above, except for the presence or absence of eugenol.

[0177] As a filter, it is not particularly limited; for example, it can be a filter for air conditioners, air purifiers, etc.

[0178] In particular, filters containing capsules are suitable for use as cigarette filters. By using such filters for cigarettes, eugenol (and consequently menthol) can be efficiently inhaled through the lungs.

[0179] Furthermore, in filters and the like, the number of capsules can be appropriately selected according to their purpose, and can be one or more. For example, as mentioned above, a filter can consist of only a first capsule (one type of capsule), or it can further include a second capsule that is different from the first capsule mentioned above, but the number of the first capsule and the number of the second capsule can each be one or more.

[0180] Cigarettes In cigarettes, there are no particular limitations on the form in which the composition is used. For example, various parts of a cigarette (tobacco leaves, filters, etc.) may contain (or have attached) the composition.

[0181] Examples of such forms include: forms containing a composition such as tobacco leaf portions {e.g., paper-rolled cigarettes, leaf-rolled (cigarettes), pipes, Japanese pipes (Kiseru), smokeless cigarettes (e.g., chewing tobacco, snuff (Swedish snuff, etc.))}, and forms using capsules or filters containing the composition in cigarettes. Typically, it is preferable to use capsules or filters containing the composition in cigarettes. Furthermore, this type of cigarette can also be a combustible cigarette (such as paper cigarettes, leaf cigarettes, pipes, Japanese pipes, hookahs) and a non-combustible cigarette [such as heated cigarettes (direct heating, air heating, etc.), smokeless cigarettes, etc.], as long as a capsule or filter is used.

[0182] <Inhalation Devices> In inhalation devices, there are no particular limitations on the form in which the composition is used. For example, various parts of the inhalation device may contain (or have attached) the composition. Inhalation devices may also contain the composition in the form of capsules.

[0183] There are no particular limitations on what constitutes an inhalation device (inhalation apparatus); for example, smoking paraphernalia can be cited. Examples of smoking devices include: heated cigarettes (vape-heated types, etc.), e-cigarettes, pipes, Japanese pipes (Kiseru), hookahs (bongs), and vaporizers. Heated cigarettes allow the ingestion of nicotine, while e-cigarettes do not contain nicotine. There are no particular restrictions on heated cigarettes; examples include: iQOS (Philip Morris), Glo (British American Tobacco), Ploom S, Ploom TECH (Japan Tobacco), and PULZE (Imperial Tobacco). There are no particular restrictions on e-cigarettes; examples include: ego AIO (Joytech) and ICE VAPE (Commonwealth).

[0184] More specific examples include: inhaled substances (such as the liquid portion of a smoking device, e-cigarette, or hookah) containing encapsulated compositions (such as eugenol or menthol). By using such substances in the inhaled substance, eugenol (and consequently menthol) can be efficiently inhaled through the lungs.

[0185] In addition to eugenol (and thus, oils and / or menthol), such inhaled substances (liquids, etc.) may contain other components, typically including carriers [liquid carriers, such as polyols (e.g., glycerin, propylene glycol, etc.)], and may also contain fragrances (fragrance liquids) as needed.

[0186] The proportion of eugenol and the like in the inhaled substance (liquid, etc.) can be selected from the same range as described above. [Example]

[0187] The present invention will now be described in detail with reference to embodiments, but the present invention is not limited thereto.

[0188] The ingredients used in the examples are shown below. Eugenol (trade name: Eugenol AKY-2348, Inabata Koryo Co., Ltd.) MCT (Product name: COCONAD ML, Kao Corporation) Menthol (Trade name: Menthol JP, Takasago Flavoring Co., Ltd.)

[0189] Furthermore, the physical properties of capsules are determined or evaluated according to the following methods. [Capsule breaking strength and elasticity (breaking distance)] The breaking strength of the capsule was measured at room temperature (22~27℃) and 40~60%RH using a Sun Scientific CR-3000EX rheometer. Furthermore, in the above measurements, the distance from deformation to capsule destruction (the distance from being pressed into the rheometer until the capsule is destroyed) is used as an indicator of the capsule's elasticity. [Capsule outer diameter] The outer diameter of the capsule was measured using a digital vernier caliper manufactured by Mitutoyo (product name: Quick Mini 25, model: PK-0510SU, measuring range: 0~25 mm) at room temperature (22~27℃) and 40~60%RH. [Capsule membrane rate] The film yield is calculated based on the formula: film yield (%) = capsule film mass / total capsule mass × 100. Furthermore, the mass was measured using an electronic balance GX-200 manufactured by A&D (shares). [Thickness of the capsule membrane] The thickness of the capsule membrane (membrane thickness) was measured using a digital microscope manufactured by Keyence (trade name: VHX-900, using a 10 μm correction scale).

[0190] Furthermore, in the embodiments, "%" is "mass%" unless otherwise specified.

[0191] <Experiment 1: The Volatilization of Menthol> Prepare the compositions shown in the table below. The prepared composition is injected into a petri dish to create a test specimen. The test sample was left uncovered at room temperature to allow it to evaporate over a certain period of time. The mass of the test sample was measured at any time point, and the amount and rate of evaporation were calculated based on the measured values. Furthermore, for those who only used eugenol as the test sample, the amount and rate of volatilization were calculated in the same way. The time constant was calculated based on the obtained measurement results [calculated by subtracting the amount of eugenol volatilization (theoretical value)]. Furthermore, the time constant can be defined, for example, as the time it takes for the mass (weight) of the remaining component (e.g., the volatile component's mass (weight) to decrease due to evaporation) in an experimental system where a certain component decreases (e.g., the mass (weight) of the remaining component (e.g., the volatile component that has not evaporated but remains) to reach 1-e-1 (or ×100%) of the initial concentration when fitted to an exponential function using the least squares method.

[0192] The results are shown in the table below. Furthermore, the unit of time constant in the table is "hour" (h) (the same applies below).

[0193] [Table 1] experiment 1A 1B 1C 1D 1E Composition Eugenol (%) 0 15 34 59.5 85 Menthol (%) 15 15 15 15 15 MCT (%) 85 70 51 25.5 0 time constant 926.3 460.8 190.0 45.6 15.6

[0194] In the above-mentioned test samples, the blending ratio of eugenol was positively correlated with the volatilization rate. Furthermore, according to the results in the table above, the time constant obtained by subtracting the amount of eugenol volatilization (theoretical value) calculated based on the volatilization of eugenol alone also shows the same tendency. Based on the above, it can be seen that eugenol promotes the volatilization of menthol, which is a volatile component (a non-volatile component).

[0195] Furthermore, promoting the volatilization of menthol will enhance its functionality or flavor.

[0196] Furthermore, as can be seen from the above experiments, eugenol itself is also volatile. Therefore, for example, when the above composition is volatilized and inhaled, menthol can be inhaled efficiently, as can eugenol.

[0197] To confirm the above situation, the following experiment was conducted.

[0198] [Effective emissions of eugenol when encapsulated or added to cigarette filters for smoking] The following easily disintegrating capsules were prepared by a dripping method, using the composition of Experiment 1B as the contents (core). The capsules were designed with the following dimensions: diameter 3.4 mm, shell thickness 50 μm, contents mass 19.3 mg, and membrane ratio 13.4%. Furthermore, the formula for the capsule's outer membrane (shell) is the same as that used in "Capsule Manufacturing Example 1" of Japanese Patent No. 6603817.

[0199] Furthermore, the capsule's breaking strength was 1530 g, and the breaking distance was 1.4 mm.

[0200] Furthermore, when you grasp the capsules and apply pressure with your fingers, they all easily break with a snapping sound, and the sound and feel of the capsules breaking is quite enjoyable. Also, the aroma of menthol (and eugenol) is very pleasant.

[0201] Next, the capsule prepared above is inserted into the center of the cigarette filter. Furthermore, the cigarettes used are CORESTA CM9 from Borgwaldt GmbH. The smoking machine uses a Linear Smoking Machine (LM2) manufactured by Borgwaldt, which smokes according to ISO 3308 (35 mL in 2 seconds, 1 puff per minute). The glass filter of the smoking machine adsorbed the vapor and particulate components of 3 cigarettes. Using ISO 10315 as a reference, the eugenol content of each cigarette was determined by GC / MS, and the result was 0.29 mg. That is, by placing the capsule into a cigarette filter, lighting the tobacco and inhaling it, it can be confirmed that 0.29 mg of eugenol has indeed volatilized and been inhaled.

[0202] <Experiment 2: The Solubility of Menthol> <Experimental Methods> Add each ingredient to a 20 mL capped glass bottle according to the mixing amounts (parts by weight) shown in the table below. Then, place the capped glass bottle into a water bath set to 25°C. After reaching 25°C, maintain the temperature for 30 minutes to adjust it. For each solution after 30 minutes, add the amount of menthol shown in the table below.

[0203] Continue to keep the bottle at 25°C. Every 20 minutes, invert the covered glass bottle to mix and visually check if the menthol has dissolved. The time until complete dissolution is recorded as the dissolution time. This 20-minute check is repeated until 360 minutes have elapsed. Then, visually check again after 3 days. If it has not dissolved after 3 days, it is considered undissolved.

[0204] Furthermore, every 20 minutes, 10 μL of the solution was sampled and added to a small glass vial containing 990 μL of standard solution for GC analysis. Sampling every 20 minutes continued until 360 minutes had elapsed, after which samples were taken again after 3 days. Then, GC analysis was performed at any point under the conditions shown in the table below. Based on the results obtained from the GC analysis, the amount of menthol dissolved was fitted using the least squares method according to an exponential function to calculate the dissolution rate time constant.

[0205] [Table 2] Internal standard solution type Mixing ratio (parts by mass) 2-Propanol 950 dodecane 20 heptadecane 20

[0206] [Table 3] Conditions for GC Analysis device GC-2014s, GC-2030 (Shimadzu Corporation) tubular DB-Heavy WAX(Agilent Technologies) Column temperature 60.0℃ vaporization chamber temperature 240℃ Detector temperature 250℃ carrier gas helium Injection volume 1.0 μl

[0207] The results are shown in the table below.

[0208] [Table 4] experiment 2A 2B 2C 2D 2E 2F 2G 2H 2I 2J Composition Eugenol (%) 0 95 0 5 40 60 80 0 15 75 MCT (%) 95 0 80 75 40 20 0 75 60 0 Menthol (%) 5 5 20 20 20 20 20 25 25 25 Dissolving time (minutes) 100 40 160 160 80 80 80 280 200 100 Dissolution rate time constant 17.3 9.0 13.1 9.2 9.0 8.2 7.7 25.4 19.7 11.6

[0209] [Table 5] experiment 2K 2L 2M 2N 2O 2P 2Q Composition Eugenol (%) 0 0 70 15 0 15 55 MCT (%) 70 0 0 45 55 40 0 Benzyl benzoate (%) 0 70 0 0 0 0 0 Menthol (%) 30 30 30 40 45 45 45 Dissolving time (minutes) 340 140 120 3 days Insoluble 3 days 220 Dissolution rate time constant 29.8 25.3 15.5 24.5 - 26.9 6.2

[0210] As shown in the table above, eugenol promotes the dissolution of menthol. Furthermore, if the dissolution rate time constant is small, then menthol dissolves faster. If the dissolution of menthol can be promoted as described above, it will be more beneficial in terms of workability. Furthermore, if it can dissolve at 25°C as described above, it is also advantageous in the following aspects: no heating is required (e.g., heating at 40°C, 60°C, etc.), reducing the number of steps, and efficiently preventing the volatilization of menthol and changes in aroma caused by heating. In particular, by blending eugenol, even if the concentration of menthol (e.g., 40% or more, 45% or more) is very high, it can still dissolve at 25°C.

[0211] <Experiment 3: Freezing Resistance> <Experimental Methods> Mix all ingredients according to the proportions (parts by weight) shown in the table below, and add the mixture to a 20 mL capped glass bottle to dissolve. Place the capped glass bottle in a water bath set to 25°C, and after reaching 25°C, maintain the temperature for 30 minutes to adjust the temperature.

[0212] Next, place the glass bottles in a freezer (approximately -20°C). Open the freezer every 30 minutes to visually check if each solution has solidified. Record the time it takes for a portion of the solution to solidify and the time it takes for the entire solution to solidify. This 30-minute check continues until 360 minutes have elapsed. Then, visually check again after 3 days. Any solution that has not solidified after 3 days is considered unsolidified.

[0213] The results are shown in the table below.

[0214] [Table 6] experiment 3A 3B 3C 3D 3E 3F 3G 3H 3I 3J Composition Eugenol (%) 0 20 40 40 0 40 0 40 0 40 MCT (%) 100 80 60 30 0 0 0 0 0 0 Diethyl succinate (%) 0 0 0 30 100 60 0 0 0 0 Diisobutyl adipate (%) 0 0 0 0 0 0 100 60 0 0 Benzyl benzoate (%) 0 0 0 0 0 0 0 0 100 60 Menthol (%) 0 0 0 0 0 0 0 0 0 0 Until partially cured (in minutes) 60 90 270 3 days - - - - - - Time until fully cured (minutes) 90 180 3 days - - - - - - -

[0215] [Table 7] experiment 3K 3L 3M 3N 3O 3P Composition Eugenol (%) 0 0 0 0 80 40 MCT (%) 80 0 0 0 0 10 Diethyl succinate (%) 0 80 0 0 0 10 Diisobutyl adipate (%) 0 0 80 0 0 10 Benzyl benzoate (%) 0 0 0 80 0 10 Menthol (%) 20 20 20 20 20 20 Until partially cured (in minutes) 90 120 180 60 330 300 Time until fully cured (minutes) 180 150 3 days 90 3 days 3 days

[0216] As shown in the table above, eugenol enhances the freeze resistance of MCT. Furthermore, it is known that eugenol, as a medium for compositions containing menthol, exhibits excellent resistance to freezing. Furthermore, it can be seen that diethyl succinate and other compounds can exert antifreeze properties when used in combination with eugenol. If such a composition is used, it is not easy to solidify even in cold regions, and the composition can be used efficiently in a wide range of areas. For example, in cases where it is used as the contents of capsules, it is particularly desirable to avoid solidification, but the composition described above can effectively prevent solidification inside the capsule even in cold regions.

[0217] Furthermore, diethyl succinate and other equivalents to the aforementioned component (X) are also more advantageous in terms of menthol solubility (and consequently, menthol aroma maintenance), and are suitable for combination with eugenol. The following presents the experimental results regarding menthol solubility.

[0218] <Experiment 4: Menthol Solubility Test> The solubility test of menthol (l-menthol) involves preparing a solution by taking menthol (l-menthol) and other components (solvents) in a total of 10 g, heating it to 50°C, dissolving it, and then storing it at 20°C. The evaluation is based on the time it takes to remain in a liquid state without solidifying. Samples that solidify immediately after being cooled to 20°C (e.g., below the melting point of l-menthol (approximately 42-45°C)) or after being stored at 20°C are rated D. Samples that remain in a molten state temporarily (e.g., for more than 30 minutes) but solidify within 24 hours are rated C. Samples that solidify within 10 days but after more than 24 hours are rated B. Samples that do not solidify within 10 days are rated A. Furthermore, in this experiment, the essential oil obtained by recrystallizing the essential oil from Canadian peppermint (which is used as menthol) through steam distillation was purchased from Anhui Tonghui Fragrance Co., Ltd., and the MCT was obtained from the pressed fruit of oil palm purchased from Kao Corporation.

[0219] The results are shown below. Furthermore, in the table, "parts by weight" and "parts by mass" have the same meaning.

[0220] [Table 8] Solubility of L-menthol when using diethyl malonate as a solvent l-Menthol (parts by weight) 80 70 60 50 Diethyl malonate (parts by weight) 20 30 40 50 Solubility B B B B

[0221] [Table 9] Dissolution of L-menthol when using diethyl succinate as a solvent l-Menthol (parts by weight) 80 70 60 50 Diethyl succinate (parts by weight) 20 30 40 50 Solubility C A A A

[0222] [Table 10] Dissolution of L-menthol when using diisobutyl adipate as a solvent l-Menthol (parts by weight) 80 70 60 50 Diisobutyl adipic acid (parts by weight) 20 30 40 50 Solubility C A A A

[0223] [Table 11] Dissolution of L-menthol when using diethyl sebacate as a solvent l-Menthol (parts by weight) 80 70 60 50 Diethyl sebacate (parts by weight) 20 30 40 50 Solubility C A A A

[0224] [Table 12] Solubility of L-menthol when using diethyl fumarate as a solvent l-Menthol (parts by weight) 70 60 50 Diethyl fumarate (parts by weight) 30 40 50 Solubility C A A

[0225] [Table 13] Solubility of L-menthol when using glyceryl tributylate as a solvent l-Menthol (parts by weight) 70 60 50 Triglyceride (parts by weight) 30 40 50 Solubility C C B

[0226] [Table 14] Solubility of L-menthol when using triethyl citrate as a solvent l-Menthol (parts by weight) 70 60 50 Triethyl citrate (parts by weight) 30 40 50 Solubility C C C

[0227] [Table 15] Solubility of L-menthol when using benzyl benzoate as a solvent l-Menthol (parts by weight) 70 60 50 Benzyl benzoate (parts by weight) 30 40 50 Solubility C C B

[0228] [Table 16] Solubility of L-menthol when using ethyl decanoate as a solvent l-Menthol (parts by weight) 70 60 50 Ethyl decanoate (parts by weight) 30 40 50 Solubility C A A

[0229] [Table 17] Solubility of L-menthol when using ethyl laurate as a solvent l-Menthol (parts by weight) 70 60 50 Ethyl lauryl acid (parts by weight) 30 40 50 Solubility C A A [Table 18] Solubility of L-menthol when using ethyl palmitate as a solvent l-Menthol (parts by weight) 70 60 50 Ethyl palmitate (parts by weight) 30 40 50 Solubility C B B

[0230] [Table 19] Solubility of L-menthol when using ethylene glycol diacetate as a solvent l-Menthol (parts by weight) 70 60 50 Ethylene glycol diacetate (parts by weight) 30 40 50 Solubility C C C

[0231] [Table 20] Solubility of 1-menthol when using 1,6-diethoxyhexane as a solvent l-Menthol (parts by weight) 70 60 50 1,6-Diethoxyhexane (parts by weight) 30 40 50 Solubility C A A

[0232] [Table 21] Solubility of 1-menthol when using 1,8-diethoxyoctane as a solvent l-Menthol (parts by weight) 70 60 50 1,8-Diethoxyoctane (parts by weight) 30 40 50 Solubility C C A

[0233] [Table 22] Solubility of L-menthol when using diethylene glycol dibutyl ether as a solvent l-Menthol (parts by weight) 70 60 50 Diethylene glycol dibutyl ether (parts by weight) 30 40 50 Solubility C A A

[0234] [Table 23] Solubility of L-menthol when using ethylene glycol dibutyl ether as a solvent l-Menthol (parts by weight) 70 60 50 Ethylene glycol dibutyl ether (parts by weight) 30 40 50 Solubility A A A

[0235] [Table 24] Solubility of 1-menthol when using N,N'-diethyl-1,6-hexanediamine as a solvent l-Menthol (parts by weight) 70 60 50 N,N'-Diethyl-1,6-hexanediamine (parts by weight) 30 40 50 Solubility A A A

[0236] [Table 25] Solubility of L-menthol when using 1,2-diethoxyethane as a solvent l-Menthol (parts by weight) 70 60 50 1,2-Diethoxyethane (parts by weight) 30 40 50 Solubility A A A

[0237] [Table 26] Solubility of l-menthol when using a mixture of diethyl succinate and MCT as a solvent l-Menthol (parts by weight) 70 70 70 65 65 65 60 60 60 Diethyl succinate (parts by weight) 10 15 20 10 15 20 10 15 20 MCT (parts by weight) 20 15 10 25 20 15 30 25 20 Solubility C C B C C A A A A

[0238] [Table 27] Solubility of 1-menthol when using a mixture of diethyl succinate, 1-decyl alcohol, and MCT as a solvent l-Menthol (parts by weight) 75 75 70 65 Diethyl succinate (parts by weight) 10 15 15 15 1-Decanol (parts by weight) 15 10 10 2 MCT (parts by weight) 0 0 5 twenty three Solubility A A A A

[0239] [Table 28] Solubility of 1-menthol when using a mixture of diethyl succinate, 1-dodecanoate, and MCT as a solvent l-Menthol (parts by weight) 80 80 75 75 70 65 Diethyl succinate (parts by weight) 10 15 10 15 15 15 1-Dodecanool (parts by weight) 10 5 15 10 10 10 MCT (parts by weight) 0 0 0 0 5 10 Solubility A A A A A A

[0240] [Table 29] The solubility of 1-menthol using diethyl succinate, diisobutyl adipate, or diethyl sebacate + 1-dodecanoate as a solvent. l-Menthol (parts by weight) 70 65 60 70 65 60 70 65 60 Diethyl succinate (parts by weight) 26 31 36 0 0 0 0 0 0 Diisobutyl adipic acid (parts by weight) 0 0 0 26 31 36 0 0 0 Diethyl sebacate (parts by weight) 0 0 0 0 0 0 26 31 36 1-Dodecanool (parts by weight) 4 4 4 4 4 4 4 4 4 Solubility A A A A A A B B B

[0241] [Table 30] Solubility of 1-menthol when using a mixture of diethyl succinate, 1-hexadecyl alcohol, and MCT as a solvent l-Menthol (parts by weight) 75 75 70 65 Diethyl succinate (parts by weight) 10 15 15 15 1-Hexadecaneol (parts by weight) 15 10 10 2 MCT (parts by weight) 0 0 5 twenty three Solubility A B A A

[0242] [Table 31] Solubility of L-menthol when using a mixture of benzyl alcohol and MCT as a solvent l-Menthol (parts by weight) 80 70 70 65 60 Benzyl alcohol (parts by weight) 20 5 10 5 5 MCT (parts by weight) 0 25 20 30 35 Solubility A A A A A

[0243] <Experiment 5: Comparative Test of Aroma A> In the aroma comparison test A, menthol and other components (solvents) were adjusted to a total of 10 g. A sensory evaluation was conducted by comparing the aroma with a menthol MCT solution (a mixture of 45% wt% menthol and 55% wt% MCT). One person performed the sensory evaluation. If the odor was the same as the menthol MCT solution, it was considered odorless; if a weaker aroma was perceived, it was considered slightly off-odor; and if a significantly stronger, different odor was perceived, it was considered off-odor present.

[0244] The results are shown below.

[0245] [Table 32] l-Menthol (parts by weight) 80 70 60 50 Diethyl succinate (parts by weight) 20 30 40 50 Aroma (whether there is any unpleasant odor) none none none none

[0246] [Table 33] l-Menthol (parts by weight) 80 70 60 50 Diisobutyl adipic acid (parts by weight) 20 30 40 50 Aroma (whether there is any unpleasant odor) none none none none

[0247] [Table 34] l-Menthol (parts by weight) 80 70 60 50 Diethyl sebacate (parts by weight) 20 30 40 50 Aroma (whether there is any unpleasant odor) none none none none

[0248] [Table 35] l-Menthol (parts by weight) 70 70 70 70 65 65 65 65 60 60 60 60 Diethyl succinate (parts by weight) 10 15 20 25 10 15 20 25 10 15 20 25 MCT (parts by weight) 20 15 10 5 25 20 15 10 30 25 20 15 Aroma (whether there is any unpleasant odor) none none none none none none none none none none none none

[0249] [Table 36] l-Menthol (parts by weight) 80 80 75 75 70 65 Diethyl succinate (parts by weight) 10 15 10 15 15 15 1-Dodecanool (parts by weight) 10 5 15 10 10 10 MCT (parts by weight) 0 0 0 0 5 10 Aroma (whether there is any unpleasant odor) none none none none none none

[0250] [Table 37] l-Menthol (parts by weight) 70 65 60 70 65 60 70 65 60 Diethyl succinate (parts by weight) 26 31 36 0 0 0 0 0 0 Diisobutyl adipic acid (parts by weight) 0 0 0 26 31 36 0 0 0 Diethyl sebacate (parts by weight) 0 0 0 0 0 0 26 31 36 1-Dodecanool (parts by weight) 4 4 4 4 4 4 4 4 4 Aroma (whether there is any unpleasant odor) none none none none none none none none none

[0251] [Table 38] l-Menthol (parts by weight) 75 75 70 65 Diethyl succinate (parts by weight) 10 15 15 15 1-Hexadecaneol (parts by weight) 15 10 10 2 MCT (parts by weight) 0 0 5 twenty three Aroma (whether there is any unpleasant odor) none none none none

[0252] [Table 39] l-Menthol (parts by weight) 70 65 60 55 50 45 40 35 MCT (parts by weight) 30 35 40 45 50 55 60 65 Aroma (whether there is any unpleasant odor) none none none none none none none none

[0253] [Table 40] l-Menthol (parts by weight) 80 70 70 65 60 d-Limonene (parts by weight) 20 5 10 5 5 MCT (parts by weight) 0 25 20 30 35 Aroma (whether there is any unpleasant odor) have have have have have

[0254] [Table 41] l-Menthol (parts by weight) 80 70 70 65 60 Benzyl alcohol (parts by weight) 20 5 10 5 5 MCT (parts by weight) 0 25 20 30 35 Aroma (whether there is any unpleasant odor) have Slightly Slightly Slightly Slightly

[0255] <Experiment 6: Comparative Test of Aromas B> In the aroma comparison test B, menthol and other ingredients (solvents) were adjusted to a total of 10 g. The aroma was compared with that of menthol through a sensory test to evaluate the product. Eight well-trained individuals conducted a sensory test, evaluating the presence or absence of an unusual odor on a scale of 5. Specifically, a score of 5 was awarded for an odor identical to that of menthol (the odor of menthol in a mixture of 45% by weight of menthol and 55% by weight of MCT); a score of 3 was awarded for a weaker, different odor; and a score of 1 was awarded for a significantly stronger, different odor. An average score of 4 or higher was designated A; an average score of 3.5 or higher but less than 4 was designated B; an average score of 3 or higher but less than 3.5 was designated C; an average score of 2 or higher but less than 3 was designated D; and an average score less than 2 was designated E.

[0256] The results are shown below.

[0257] [Table 42] l-Menthol (parts by weight) 70 60 50 50 50 60 70 Diethyl malonate (parts by weight) 30 40 50 0 0 0 0 Diethyl succinate (parts by weight) 0 0 0 50 0 0 0 Diisobutyl adipic acid (parts by weight) 0 0 0 0 50 0 0 Diethyl sebacate (parts by weight) 0 0 0 0 0 40 30 Functional test scores 3.00 3.00 2.25 4.00 3.50 4.25 4.13 evaluate A A B A B A A

[0258] [Table 43] l-Menthol (parts by weight) 70 60 50 Diethyl fumarate (parts by weight) 30 40 50 Functional test scores 2.00 1.75 1.00 evaluate D E E

[0259] [Table 44] l-Menthol (parts by weight) 60 50 Triglyceride (parts by weight) 40 50 Functional test scores 3.88 3.50 evaluate B B

[0260] [Table 45] l-Menthol (parts by weight) 70 60 50 Triethyl citrate (parts by weight) 30 40 50 Functional test scores 4.00 3.75 3.63 evaluate A B B

[0261] [Table 46] l-Menthol (parts by weight) 70 60 50 Benzyl benzoate (parts by weight) 30 40 50 Functional test scores 4.00 3.75 3.88 evaluate A B B

[0262] [Table 47] l-Menthol (parts by weight) 70 60 50 Diethylene glycol dibutyl ether (parts by weight) 30 40 50 Functional test scores 2.25 2.50 2.25 evaluate D D D

[0263] [Table 48] l-Menthol (parts by weight) 70 50 N,N'-Diethyl-1,6-hexanediamine (parts by weight) 30 50 Functional test scores 1.63 1.25 evaluate E E

[0264] [Table 49] l-Menthol (parts by weight) 80 80 80 80 Diethyl succinate (parts by weight) 10 15 0 0 Diisobutyl adipic acid (parts by weight) 0 0 10 15 Dodecanool (parts by weight) 10 5 10 5 Functional test scores 4.00 4.25 3.88 4.38 evaluate A A B A

[0265] [Table 50] l-Menthol (parts by weight) 60 50 40 MCT (parts by weight) 40 50 60 Functional test scores 4.13 4.75 4.63 evaluate A A A

[0266] [Table 51] l-Menthol (parts by weight) 80 70 70 65 60 d-Limonene (parts by weight) 20 5 10 5 5 MCT (parts by weight) 0 25 20 30 35 Functional test scores 2.00 2.25 2.38 2.25 2.63 evaluate D D D D D

[0267] [Table 52] l-Menthol (parts by weight) 80 70 70 65 60 Benzyl alcohol (parts by weight) 20 5 10 5 5 MCT (parts by weight) 0 25 20 30 35 Functional test scores 1.75 2.38 2.13 2.38 2.13 evaluate E D D D D

[0268] <Experiment 7: Encapsulation> As can be seen from Experiment 1 above, the composition used in the above experiment can be encapsulated. However, in reality, it has been confirmed that all compositions can be encapsulated without hindrance, just like in Experiment 1.

[0269] Furthermore, it was confirmed that, except for the capsules in Experiment 1 (capsules with a diameter of 3.4 mm), all compositions could be prepared into the four types of easily disintegrating capsules shown below by the drip method. Moreover, the capsule membranes (outer shells) were identical.

[0270] Capsule diameter: 2.8 mm, shell thickness: 57 μm, breaking strength: 1180 g, breaking distance: 1.5 mm Capsule diameter: 3.0 mm, shell thickness: 48 μm, breaking strength: 1270 g, breaking distance: 1.6 mm Capsule diameter: 3.5 mm, shell thickness: 48 μm, breaking strength: 1670 g, breaking distance: 1.8 mm Capsule diameter: 4.0 mm, shell thickness: 45 μm, breaking strength: 2060 g, breaking distance: 2.0 mm

[0271] That is, all compositions are filled into various seamless capsules (easily disintegrating capsules) by drip filling. [Industrial Applicability]

[0272] The present invention provides compositions containing eugenol, etc.

Claims

1. A composition comprising eugenol and menthol, wherein the eugenol content is more than 1% by mass and less than 99.9% by mass.

2. A composition comprising eugenol, menthol, and at least one oil selected from vegetable oils, animal oils, and MCT, wherein the eugenol content is more than 1% by mass and less than 99.9% by mass.

3. The composition of claim 1 or 2, wherein the oil contains MCT.

4. The composition of claim 1 or 2, wherein the ratio of eugenol is more than 3% by mass and less than 95% by mass, and the ratio of eugenol to the total amount of eugenol and menthol is 5 to 95% by mass.

5. The composition of claim 2, wherein the ratio of eugenol is 3% by mass or more and 95% by mass, and the ratio of eugenol to the total amount of eugenol, menthol and oil is 5% to 95% by mass.

6. The composition of claim 1 or 2, wherein the menthol content is 15% by mass or more and 95% by mass or less.

7. The composition of claim 1 or 2 further comprises at least one component (X) selected from dicarboxylic acid esters, diol esters, monocarboxylic acid esters, polyol esters having three or more hydroxyl groups, polycarboxylic acid esters having three or more carboxyl groups, polyol ethers, polyamines, and alcohols having six or more carbon atoms.

8. The composition of claim 1 or 2 further comprises (X) as a dicarboxylic acid ester.

9. The composition of claim 1 or 2 further comprises at least one component (X) selected from C2-20 saturated dicarboxylic acid esters, C4-20 unsaturated dicarboxylic acid esters, C8-20 aromatic dicarboxylic acid esters, C2-20 aliphatic diol-diesters, C1-30 aliphatic carboxylic acids, C6-20 aromatic carboxylic acid-esters, triC1-6 aliphatic carboxylic acid esters, triC6-10 aromatic carboxylic acid esters, tricarboxylic acid triC1-6 alkyl esters, C2-20 aliphatic diol-ethers, N-unsubstituted polyamines, N-substituted polyamines, aliphatic alcohols having 6 or more carbon atoms, aromatic aliphatic alcohols having 6 or more carbon atoms, and aromatic alcohols having 6 or more carbon atoms.

10. The composition of claim 7, wherein the ratio of component (X) is more than 1% by mass and less than 97% by mass.

11. The composition of claim 7, wherein the ratio of component (X) is more than 3% by mass and less than 97% by mass, and the ratio of component (X) to eugenol and the total amount of component (X) is 5 to 95% by mass.

12. The composition of claim 1 or 2 is in liquid form.

13. The composition of claim 1 or 2, used in the contents of a capsule.

14. A capsule comprising a core and a shell, wherein the core is a composition as claimed in claim 1 or 2.

15. A filter comprising a capsule, wherein the capsule comprises a core and a shell, and the core is a composition of any one of claims 1 to 13.

16. A cigarette comprising a composition as claimed in any one of claims 1 to 13.

17. An inhalation device comprising a composition of any one of claims 1 to 13.

18. The inhalation device in claim 17 is a smoking device.

19. A cigarette or smoking device as claimed in any of claims 16 to 18, which contains a capsule or filter as claimed in claim 14 or 15.

20. A volatile enhancer for menthol, comprising eugenol, and using eugenol at a ratio of 1% to 99.9% by mass.

21. A menthol solubility enhancer comprising eugenol, wherein the eugenol is applied at a ratio of 1% to 99.9% by mass.

22. A method for improving the volatility and / or solubility of menthol, comprising mixing eugenol into menthol at a ratio of more than 1% by mass and less than 99.9% by mass to improve the volatility and / or solubility of menthol.

23. A method for pulmonary ingestion of eugenol, comprising pulmonary ingestion of eugenol using any of the capsules, filters, cigarettes and / or inhalation devices as claimed in any of claims 14 to 19.