A dual-functional electrochemical and surface-enhanced raman spectroscopy sensing element with metal-organic framework

Abstract

A bifunctional electrochemical and surface-enhanced Raman spectroscopy sensing element with an organometallic framework includes a flexible substrate, a sensing unit disposed on the flexible substrate, and an electrode unit connected to the sensing unit. In particular, the sensing unit has a sensing enhancement layer, and the material constituting the sensing enhancement layer includes an organometallic framework and a plurality of metal nanoparticles bonded to the surface of the organometallic framework. By utilizing the high specific surface area and porosity of the organometallic framework, it can effectively adsorb analyte molecules, thereby further enhancing the Raman spectroscopy and electrochemical signals of the sensing element, thus effectively improving the detection sensitivity.

Claims

1. A bifunctional electrochemical and surface-enhanced Raman spectroscopy sensing element with an organometallic framework, comprising: a flexible substrate made of a polymer material; a sensing unit disposed on the flexible substrate, having a sensing enhancement layer and a carbonized layer between the sensing enhancement layer and the flexible substrate, the carbonized layer being formed by carbonizing the polymer material of the flexible substrate, the sensing enhancement layer comprising an organometallic framework and a plurality of metal nanoparticles formed on the surface of the organometallic framework; and an electrode unit connected to the sensing unit, wherein... This sensing element is suitable for detecting uremic toxins. The organometallic framework is ZIF-67, and the metal nanoparticles are gold nanoparticles.

2. The sensing element as described in claim 1, wherein, The electrode unit includes at least one electrode connected to the sensing unit.

3. The sensing element as described in claim 2, wherein, The at least one electrode includes a carbonized layer formed by carbonizing a polymeric material from the flexible substrate.

4. The sensing element as described in claim 3, wherein, The at least one electrode also includes a metal layer formed on the surface of the carbide layer.

5. The sensing element as claimed in claim 2, wherein, The electrode unit includes three electrodes: an auxiliary electrode, a reference electrode, and a working electrode. One end of the working electrode is connected to the sensing enhancement layer, and one end of the auxiliary electrode and the reference electrode are adjacent to and spaced apart from the sensing enhancement layer.

6. The sensing element as claimed in claim 3, wherein, The flexible substrate is made of a polymer or cellulose ester with aromatic rings.

7. The sensing element as claimed in claim 1 further includes a blocking member disposed on the flexible substrate and corresponding to the sensing unit, the blocking member being hollow and ring-shaped, and enclosing a detection space for accommodating a liquid phase sample to be tested on the sensing unit.

8. The sensing element as claimed in claim 1, wherein, The surface of the carbonized layer is hydrophilic.

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