Peptides used to treat pancreatic cancer and inhibit periodontal disease pathogens.

TWI939139BActive Publication Date: 2026-09-11CHUNG SHAN MEDICAL UNIVERSITY +1
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Patent Information

Application Number
TW114129282
Authority / Receiving Office
TW · TW
Patent Type
Patents
Current Assignee / Owner
Filing Date
2025-08-01
Publication Date
2026-09-11
Estimated Expiration
2045-07-31

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  • Figure TWG2TB001910707_001
    Figure TWG2TB001910707_001
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    Figure TWG2TB001910707_002
  • Figure TWG2TB001910707_003
    Figure TWG2TB001910707_003
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Abstract

This invention discloses a peptide for treating pancreatic cancer and inhibiting periodontal disease pathogens. The amino acid sequence of the peptide is as shown in SEQ ID No. 1 or SEQ ID No. 2, and it has the ability to bind to gingival protease and inhibit its activity. Therefore, by administering an effective amount of the peptide shown in SEQ ID No. 1 and / or SEQ ID No. 2 to an individual, the activity of gingival protease can be inhibited, thereby achieving the therapeutic or improvement effects on pancreatic cancer and / or periodontal disease.
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Claims

1. Use of a peptide in the preparation of compositions for the treatment or prevention of pancreatic cancer, wherein: The amino acid sequence of the peptide is shown in SEQ ID No. 1 or SEQ ID No.

2.

2. Use of the peptide described in claim 1 in the preparation of compositions for the treatment or prevention of pancreatic cancer, wherein, This peptide can be used to inhibit gingival protease.

3. Use of the peptide described in claim 2 in the preparation of compositions for the treatment or prevention of pancreatic cancer, wherein, The gingival protease system is either Rgp (Arginine-specific gingipain) or Kgp (Lysine-specific gingipain).

4. Use of a peptide in the preparation of a composition for treating periodontal disease, wherein: The amino acid sequence of the peptide is shown in SEQ ID No. 1 or SEQ ID No.

2.

5. The use of a peptide in the preparation of a gingival protease inhibitor, wherein: The amino acid sequence of the peptide is shown in SEQ ID No. 1 or SEQ ID No.

2.

6. The use of the peptide described in claim 5 for the preparation of a gingival protease inhibitor, wherein, This gingival protease inhibitor is used to inhibit Rgp (Arginine-specific gingipain) or Kgp (Lysine-specific gingipain).

7. A peptide having the amino acid sequence shown in SEQ ID No.

2.

8. A pharmaceutical composition comprising an effective amount of the peptide shown in SEQ ID No. 2.

Citation Information

Patent Citations

  • Peptide having affinity for and / or inhibitory function against gingipains, and use thereof

    WO2023182185A1