Fiber scaffold and system for improving cell growth

Abstract

This invention discloses a fiber scaffold comprising electrospun polymer fibers, the electrospun polymer fibers comprising a copolymer having the following chemical formula: Poly((CBZL)-co-(BG)), wherein CBZL is an N6-benzyloxycarbonyl-L-lysine residue; BG is an L-glutamic acid-γ-benzyl ester residue; and the molar ratio of CBZL to BG is 7:3. This invention also discloses a system for promoting cell growth comprising the fiber scaffold, the cells being nerve cells or neural precursor cells.

Claims

1. A fiber scaffold comprising an electrospun polymer fiber, the electrospun polymer fiber comprising a copolymer having the following chemical formula: Poly((CBZL)-co-(BG)) wherein CBZL is an N6-benzyloxycarbonyl-L-lysine residue; BG is an L-glutamic acid-γ-benzyl ester residue; and the molar ratio of CBZL to BG is 7:

3.

2. The fiber scaffold as claimed in claim 1, wherein the copolymer is formed from N6-benzyloxycarbonyl-L-lysine-N-carboxylic anhydride (CBZLNCA) and L-glutamic acid-γ-benzyl ester-N-carboxylic anhydride (BGNCA).

3. The fiber scaffold as claimed in claim 1, wherein the electrospun polymer fiber has a diameter ranging from 0.6 μm to 1.2 μm.

4. A system for promoting cell growth comprising a fibrous scaffold as described in claim 1, wherein the cell is a nerve cell or a neural precursor cell.

5. The system as claimed in claim 4, wherein the electrospun polymeric fiber further comprises minocycline.

6. The system as claimed in claim 5, wherein the minocycline has a concentration ranging from 2 wt% to 8 wt%.

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