Use of composition containing chenopodium formosanum sprout

Abstract

This invention discloses the use of a composition containing *Chenopodium taiwanense* buds in the preparation of a medicament for improving muscle endurance and / or having anti-fatigue effects. The composition comprises 20 parts by weight of *Chenopodium taiwanense* buds, 4 parts by weight of *Cordyceps sinensis* powder, 3 parts by weight of grape peel pigment, and 2 parts by weight of olive leaf extract. Through the synergistic effect of these components, it can improve forelimb grip strength and prolong weight-bearing swimming time to achieve an anti-fatigue effect; it can inhibit the expression of NF-κB, TNF-α, and IL-6 to alleviate post-exercise muscle inflammation; it can promote Nrf2 nuclear translocation and upregulate HO-1 expression to enhance antioxidant protection; it can increase the p-AMPK / AMPK ratio and upregulate PGC-1α expression to promote energy metabolism; and it can reduce post-exercise blood urea nitrogen and lactate concentrations and increase liver glycogen content to improve energy reserves and promote recovery.

Claims

1. The use of a composition comprising Taiwanese quinoa buds in the preparation of a medicament for improving muscle endurance and / or having anti-fatigue effects, wherein, The composition comprises 20 parts by weight of Taiwan gooseberry buds, 4 parts by weight of Cordyceps sinensis powder, 3 parts by weight of grape skin pigment and 2 parts by weight of olive leaf extract. The Taiwan gooseberry buds are a mixture of buds obtained from Taiwan gooseberry seeds after germination and cultivation for 5 days and the remaining seed parts. The composition is administered to a desired individual at an effective dose of 8.2 g / kg body weight / day.

2. As in the purpose of request item 1, wherein, The grape skin pigment contains 85% pure anthocyanin.

3. As in the purpose of request item 1, wherein, This olive leaf extract contains 16–24% oleuropein by weight.

4. As in the use of any of the items in request 1, wherein, This composition improves forelimb grip strength and extends weight-bearing swimming time.

5. For any of the uses of items 1 to 4, wherein, This composition inhibits the expression of NF-κB, TNF-α, and IL-6.

6. For any of the uses of items 1 to 4, wherein, This composition promotes Nrf2 nuclear translocation and upregulates HO-1 performance.

7. For any of the uses of items 1 to 4, wherein, This composition improves the p-AMPK / AMPK ratio and upregulates the performance of PGC-1α.

8. For any of the uses of items 1 to 4, wherein, This composition reduces blood urea nitrogen (BUN) and lactic acid (BLA) levels after exercise and increases glycogen content in the calf muscles and liver.

9. As used in request item 1, wherein, This composition reduces the concentration of malondialdehyde (MDA) in the gastrocnemius muscle and increases the activity of superoxide dismutase (SOD) and glutathione reductase (GRd).

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