A hydrogel composition and preparation method thereof

Abstract

A hydrogel composition and its preparation method are disclosed. The preparation method involves dissolving and mixing a selected water-soluble polysaccharide with a protein, followed by high-temperature and high-pressure heat treatment, and then freeze-drying / pulverizing / sieving to obtain a superabsorbent hydrogel freeze-dried powder. This hydrogel freeze-dried powder composition is a safe, self-disintegrating superabsorbent hydrogel suitable for applications in healthy weight management.

Claims

1. A method for preparing a hydrogel composition, comprising: dissolving a water-soluble polysaccharide and a protein separately in a solvent, then mixing the two solutions to form a precursor solution, wherein, based on the total weight of the precursor solution, the total amount of the water-soluble polysaccharide and the protein is 0.05 wt% to 4 wt%, wherein... The ratio of the protein to the polysaccharide by weight is 50:50 to 95:5; the precursor solution is heat-treated at a temperature between 110°C and 140°C and a pressure between 15 and 20 psi for 5 to 60 minutes to obtain a monohydrate.

2. The preparation method as described in claim 1, further comprising freeze-drying and pulverizing the hydrocolloid to obtain a hydrocolloid freeze-dried powder.

3. The preparation method as described in claim 2, further comprising mixing the hydrogel freeze-dried powder with a foaming agent to form an tablet, wherein the proportion of the foaming agent in the tablet is 2 to 30 wt%.

4. The preparation method as described in claim 3, wherein the foaming agent is sodium bicarbonate.

5. The preparation method as described in claim 1, wherein the protein is a water-soluble protein.

6. The preparation method as described in any one of claims 1 to 3, wherein the solvent is water, the protein is gelatin, the water-soluble polysaccharide is carboxymethyl cellulose (CMC), the precursor solution is substantially composed of the solvent, gelatin, and carboxymethyl cellulose (CMC), but does not contain any additional crosslinking agent, and the heat treatment time is 35 to 42 minutes.

7. The preparation method as described in any one of claims 1 to 3, wherein the solvent is calcium chloride (CaCl2), ethanol, and water mixed in a molar ratio of 1:2:8, the protein is silk fibroin, the water-soluble polysaccharide is carboxymethyl cellulose (CMC), the precursor solution is substantially composed of the solvent, silk fibroin, and cellulose, but does not contain any additional crosslinking agent, and the heat treatment time is 5 to 30 minutes.

8. The preparation method as described in any one of claims 1 to 3, wherein the water-soluble polysaccharide is selected from at least one or more of the group consisting of methylcellulose, hydroxyethylcellulose, hydroxy-n-propylcellulose, hydroxy-n-butylcellulose, hydroxypropylmethylcellulose, ethyl hydroxyethylcellulose, carboxymethylcellulose, gum arabic, carboxymethyl starch, dextran sulfate, phosphate dextran, diethylamino dextran, heparin, hyaluronic acid, chondroitin, chondroitin sulfate, heparin sulfate, polyglucuronic acid, polymannuronic acid, polygalacturonic acid, and polyarabic acid.

9. The preparation method as described in any one of claims 1 to 3, wherein the protein is selected from at least one or more of the group consisting of silk fibroin, recombinant silk fibroin, gelatin, collagen, elastin, β-lactamase, β-lactoglobulin, casein, myofibrillar protein, ovalbumin, proteoglycans, and soy protein.

10. A water-based adhesive composition prepared by any one of the water-based adhesive composition preparation methods of claims 1 to 9.

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