Use of a grouper hydrolysate in the preparation of a composition for preventing or improving dyslipidemia, hyperglycemia, and / or antioxidative ability

Abstract

The use of a grouper hydrolysate in the preparation of a composition for preventing or improving blood lipids, blood glucose, and / or reducing serum lipid oxidation, the composition containing an effective amount of the grouper hydrolysate, which is prepared by hydrolyzing a grouper extract with alkaline protease, the grouper hydrolysate having a specific free amino acid composition, such as branched-chain amino acids, taurine, acidic amino acids; and several functional peptides, including L-aspergyl carnosine, the content of which is between 50 and 500 mg / 100g. When the composition is administered to an individual, the grouper hydrolysate inhibits the activity of pancreatic lipase and dipeptidyl peptidase-IV, promotes bile acid binding capacity, and provides the effect of reducing serum triglycerides, cholesterol, blood glucose, and serum lipid oxidation.

Claims

1. Use of a grouper hydrolysate in the preparation of a composition for preventing or improving blood lipids, blood glucose, and / or antioxidant levels, the composition containing an effective amount of the grouper hydrolysate, wherein the effective amount of the grouper hydrolysate is between 50 and 200 mg / kg, the grouper hydrolysate is prepared by hydrolyzing a grouper extract with alkaline protease, the grouper hydrolysate having a plurality of functional peptides, the functional peptides including L-aspergylcarnosine, the L-aspergylcarnosine content being between 50 and 500 mg / 100g, and the functional peptides comprising SEQ ID NO: 1, SEQ ID NO: 2 and / or SEQ ID NO:

1. NO:3, when this component is administered to an individual, the grouper hydrolysate inhibits the activity of pancreatic lipase, dipeptidyl peptidase-IV and angiotensin-converting enzyme, promotes bile acid binding capacity, and provides the effect of reducing serum triglycerides, cholesterol and cholesterol ratio (LDL-C / HDL-C), blood glucose and serum lipid oxidation.

2. The use of the grouper hydrolysate as described in claim 1 for the preparation of a composition for the prevention or improvement of blood lipids and / or blood sugar, wherein the mass ratio of the alkaline protease to the grouper extract is between 1:50 and 1:500 (w / w), and the hydrolysis time is between 1 and 4 hours.

3. The use of the grouper hydrolysate as described in claim 1 for preparing a composition for preventing or improving blood lipids, blood sugar and / or antioxidant levels, wherein the functional peptides further comprise L-carnosine in a concentration of 50 to 200 mg / 100g.

4. Use of the grouper hydrolysate as described in claim 1 for the preparation of a composition for the prevention or improvement of blood lipids, blood sugar and / or antioxidants, wherein the grouper extract is derived from grouper head or grouper head meat.

5. The use of the grouper hydrolysate as claimed in claim 1 for preparing a composition for preventing or improving blood lipids, blood sugar and / or antioxidation, wherein the grouper hydrolysate comprises branched-chain amino acids, taurine and acidic amino acids, wherein the content of the branched-chain amino acids is between 80 and 400 mg / 100g, the content of the taurine is between 500 and 800 mg / 100g, the acidic amino acids include aspartic acid and glutamic acid, wherein the content of the aspartic acid is between 15 and 25 mg / 100g, and the content of the glutamic acid is between 10 and 250 mg / 100g.

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