Pregnancy medication evaluation system

Abstract

A pregnancy medication assessment system is provided, comprising a data establishment module, a data correlation quantification module, and a data analysis module. The data establishment module retrieves real-world data from at least one database and filters multiple pregnancy medication prescriptions, each including prescription information and diagnostic information. The data correlation quantification module calculates quantitative correlation values ​​between multiple diagnoses and drugs, and between multiple drugs, based on the multiple pregnancy medication prescriptions. The data analysis module constructs an indication module, a dosage module, and a drug interaction module based on the multiple pregnancy medication prescriptions and these quantitative correlation values. The indication module establishes reference information for the indications of each prescribed drug, the dosage module establishes reference information for the prescribed dosages of each prescribed drug, and the drug interaction module establishes information on the drug interactions between any two prescribed drugs.

Claims

1. A pregnancy medication assessment system, comprising: The data creation module is configured to connect to at least one database and is used to obtain real-world data from the at least one database and to filter multiple pregnancy medication prescription data from the real-world data, wherein each of the multiple pregnancy medication prescription data includes at least one prescribed drug and at least one diagnosis to form a combination of at least one diagnosis and drug. A data correlation quantification module is electrically connected to the data creation module and is used to calculate the correlation quantification values ​​between multiple diagnoses and drugs and the correlation quantification values ​​between multiple drugs based on the multiple pregnancy medication prescription data; and a data analysis module is electrically connected to the data creation module and the correlation quantification module and is used to construct an indication module, a dosage module and a drug interaction module based on the multiple pregnancy medication prescription data, the correlation quantification values ​​between multiple diagnoses and drugs and the correlation quantification values ​​between multiple drugs, wherein the indication module is used to establish indication reference information for each of the at least one prescribed drug, the dosage module is used to establish dosage reference information for each of the at least one prescribed drug, and the drug interaction module is used to establish drug interaction reference information for any two of the at least one prescribed drug.

2. The pregnancy medication assessment system as described in claim 1, wherein, The correlation quantification module also performs spurious correlation correction on the correlation quantification values ​​between the complex diagnosis and the drug to eliminate correlation quantification values ​​that may lead to spurious correlation misjudgments.

3. The pregnancy medication assessment system as described in claim 2, wherein, This pseudo-correlation correction is based on the multiple pregnancy medication prescription data for the same person. It calculates the correlation between the single drug and multiple diagnoses to form multiple diagnosis and drug combinations, and selects the highest correlation between the diagnosis and drug combinations as the correct diagnosis and drug combinations.

4. The pregnancy medication assessment system as described in claim 3, wherein, When performing this pseudo-association correction, if in the multiple pregnancy medication prescription data, there is another diagnosis that belongs to the same disease classification code as the correct diagnosis and medication combination, the correlation quantification value between the diagnosis and medication calculated for the other diagnosis is also selected.

5. The pregnancy medication assessment system as described in claim 1, wherein, The prescription data for each pregnancy refers to the outpatient medical records of pregnant women who have successfully delivered their babies, starting from the date of birth of the newborn, and tracing back the gestational weeks of the pregnancy.

6. The pregnancy medication assessment system as described in claim 1, further comprising an interface processing module for generating a user interface, wherein, The user interface is used to receive drug input information, and the data analysis module performs comparative analysis on the drug input information to generate result display information, which is presented through the user interface. The result display information includes at least one of the indication reference information, the dosage reference information, and the drug interaction reference information.

7. The pregnancy medication assessment system as described in claim 6, wherein, The results show that the information also includes drug classification information for drugs of the same class that are included in the drug input information.

8. The pregnancy medication assessment system as described in claim 2, wherein, Based on the results of performing the pseudo-association correction, the indication module establishes reference information for the indication of each of the at least one prescribed drug.

9. The pregnancy medication assessment system as described in claim 1, wherein, The dosage module determines that the quantitative value of the correlation between the diagnosis and the drug corresponding to any prescribed drug in the multiple pregnancy medication prescription data is not less than a set threshold, and uses the daily dosage set by the World Health Organization for the prescribed drug as the measurement standard, and establishes the dosage reference information of the prescribed drug for the diagnosis.

10. The pregnancy medication assessment system as described in claim 1, wherein, The data analysis module also includes a validation module, which receives expert evaluation information and performs sensitivity analysis based on the expert evaluation information for the indication reference information established by the indication module and the dose reference information established by the dose module.

11. The pregnancy medication assessment system as described in claim 1, wherein, The drug interaction module is based on the quantitative value of the drug-drug correlation between one of the at least one prescribed drugs and another of the multiple pregnancy medication prescription data, combined with drug classification information from at least one drug database, to establish drug interaction reference information for the at least one prescribed drug.

12. The pregnancy medication assessment system as described in claim 11, wherein, This drug interaction information is graded and labeled according to different levels of drug interaction, making the reference information on drug interaction visually differentiated.

13. The pregnancy medication assessment system as described in claim 1, wherein, The data creation module uses ATC standard coding to identify each prescribed drug and reclassified ICD-10-CM codes to identify each diagnosis, thereby reducing the number of combinations of at least one diagnosis and drug formed.

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