Microcapsule sphere structure

Abstract

A microcapsule sphere structure is disclosed, comprising a sphere body including a core and a coating layer. The core is composed of an inner phase solution comprising deionized water and glycerol, sodium hyaluronate, emulsifier, preservative, and active ingredient dissolved or dispersed in the deionized water. The coating layer, covering the core, is formed by an outer phase solution undergoing an ionic cross-linking reaction with at least one cross-linking agent. The outer phase solution comprises deionized water and sodium alginate, hydroxyethyl cellulose, glycerol, and preservative dissolved in the deionized water. Furthermore, the surface of the coating layer is treated with a chelating agent solution to reduce the ionic cross-linking density of the coating layer and remove residual cross-linking agent, giving the microcapsule sphere a stable structure that protects the active ingredient and allows it to easily rupture and release the active ingredient under external shear force.

Claims

1. A microcapsule sphere structure having a sphere body, the sphere body comprising: The core consists of an internal phase solution, which includes deionized water and glycerin, sodium hyaluronate, emulsifier, preservative and active ingredients dissolved in the deionized water; And, a coating layer covering the core, the coating layer being formed by an ionic crosslinking reaction of an outer phase solution with at least one crosslinking agent, the outer phase solution including deionized water and sodium alginate, hydroxyethyl cellulose, glycerol and preservative dissolved in the deionized water; wherein, the coating layer has a surface state treated with a chelating agent solution, the ionic crosslinking density of the coating layer being adjusted by the treatment with the chelating agent solution.

2. The microcapsule sphere structure as described in claim 1, wherein, Based on the total weight of the internal phase solution as 100%, glycerin is 1 wt% to 10 wt%, sodium hyaluronate is 0.01 wt% to 1 wt%, emulsifier is 0.1 wt% to 1 wt%, preservative is 0.1 wt% to 2 wt%, active ingredient is 1 wt% to 10 wt%, and the remainder is deionized water.

3. The microcapsule sphere structure as described in claim 1, wherein, Based on the total weight of the external phase solution as 100%, sodium alginate is 0.1wt% to 1wt%, hydroxyethyl cellulose is 0.1wt% to 1wt%, glycerol is 1wt% to 10wt%, preservative is 0.1wt% to 2wt%, and the remainder is deionized water.

4. The microcapsule sphere structure as described in claim 1, wherein, The active ingredient is selected from vitamin B12, pearlescent luminous factor, blue copper peptide, coenzyme Q10, or any combination thereof.

5. The microcapsule sphere structure as described in claim 1, wherein, The crosslinking agent includes divalent metal ions, and the divalent metal ions are selected from calcium ions (Ca2+), magnesium ions (Mg2+), zinc ions (Zn2+) or any combination thereof.

6. The microcapsule sphere structure as described in claim 1, wherein, The chelating agent solution is an aqueous solution containing 0.1 wt% to 1 wt% of a chelating agent selected from ethylenediaminetetraacetic acid, sodium ethylenediaminetetraacetic acid, or any combination thereof.

7. The microcapsule sphere structure as described in claim 1, wherein, The particle size of the crystal body ranges from 40 μm to 500 μm.

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