bitter melon extract microparticles

Abstract

This invention relates to a microparticle containing bitter melon extract, comprising: a microparticle body, which is a solid sphere formed by uniformly mixing bitter melon extract with a pharmaceutically acceptable binder and then granulating the mixture; the bitter melon extract contains effective amounts of bitter substances, momordicin, and bitter melon peptides; and a protective layer covering the outside of the microparticle body. In this way, the microparticle can effectively protect the active ingredients in the bitter melon extract, improve its storage stability and bioavailability, and achieve excellent blood sugar regulation effects through multiple pathways, including inhibiting carbohydrate digestive enzymes and promoting glucose oxidation and glycogen accumulation. It is particularly suitable for the health management of diabetic patients and people at high risk of blood sugar.

Claims

1. A type of bitter melon extract microparticles, comprising: a microparticle body, the microparticle body being a solid sphere, formed by granulation after uniformly mixing an effective amount of bitter melon extract with a pharmaceutically acceptable binder; wherein, The bitter melon extract contains at least bitter substances, momordicin, and bitter melon peptides, and the structure of the microparticles is suitable for providing good fluidity and uniform and controllable release of active ingredients in the digestive tract.

2. The bitter gourd extract microparticles as described in claim 1 further include a protective layer covering the outside of the microparticle body.

3. The bitter gourd extract microparticles as described in claim 2, wherein the protective layer is an enteric coating or a sustained-release coating.

4. The bitter melon extract particles as described in claim 1, wherein the bitter melon peptides contained in the bitter melon extract have a molecular weight of approximately 10,000 Daltons.

5. The bitter melon extract particles as described in claim 1, wherein the bitter melon extract contains not less than 6.0% bitter glycoside, not less than 5.0% bitter melon glycoside, and not less than 1.5% bitter melon peptide.

6. The bitter gourd extract microparticles as described in claim 1, wherein the average particle size of the microparticles ranges from 100 micrometers to 800 micrometers.

7. The bitter gourd extract microparticles as described in claim 1, wherein the binder is selected from the group consisting of starch, cellulose derivatives, polyvinylpyrrolidone (PVP) or other pharmaceutical or food grade polymers.

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