A prognostic stratification system for interstitial lung disease driven by total cardiopulmonary exercise test scores.

Abstract

The cardiopulmonary exercise test (CPT) total score-driven prognostic stratification system for interstitial lung disease provided in this invention comprises a database unit and a processing device. The database unit stores CPT data for at least one patient. The processing device includes a communication unit and a calculation unit. The communication unit is electrically connected to the database unit to retrieve the patient's CPT data from the database. The calculation unit is electrically connected to the communication unit to receive the CPT data, extract a majority of calibrated physiological parameters, and perform a binary comparison of these calibrated physiological parameters with their respective optimal cutoff values ​​to generate corresponding binary logical values. Each binary logical value has a first logical state representing risk and a second logical state representing safety. When the number of first logical states is greater than 1, the processing device outputs a risk warning for the patient indicating a poor long-term prognosis.

Claims

1. A prognostic stratification system for interstitial lung disease driven by a total cardiopulmonary exercise test score, comprising: a database unit storing cardiopulmonary exercise test data of at least one patient; a processing device including a communication unit communicatively connected to the database unit for retrieving the patient's cardiopulmonary exercise test data from the database unit; and a calculation unit electrically connected to the communication unit for receiving the cardiopulmonary exercise test data, extracting a plurality of calibrated physiological parameters from it, and performing a binary comparison of these calibrated physiological parameters with their respective corresponding optimized cutoff values ​​to generate corresponding binary logical values, wherein... The binary logic value has a first logic state representing risk and a second logic state representing safety. When the number of the first logic states is greater than 1, the processing device outputs a risk warning of poor long-term prognosis to the patient.

2. The interstitial lung disease prognostic stratification system driven by the total cardiopulmonary exercise test score as described in claim 1, wherein, These calibrated physiological parameters include gas exchange indicators, ventilation efficiency indicators, and cardiovascular response indicators.

3. A prognostic stratification system for interstitial lung disease driven by the total score of cardiopulmonary exercise testing as described in claim 2, wherein, This gas exchange indicator includes the Functional Aerobic Impairment (FAI) and peak end-tidal carbon dioxide partial pressure (PETCO2).

4. A prognostic stratification system for interstitial lung disease driven by the total score of cardiopulmonary exercise testing as described in claim 3, wherein, The optimal cutoff value for the Functional Lung Injury Index (FAI) was 25.1%, and the optimal cutoff value for the peak end-tidal carbon dioxide partial pressure (PETCO2) was 34.1 mmHg.

5. A prognostic stratification system for interstitial lung disease driven by the total score of cardiopulmonary exercise testing as described in claim 2, wherein, The ventilation efficiency index is the ventilation / carbon dioxide discharge slope (V̇E / V̇CO2 slope).

6. A prognostic stratification system for interstitial lung disease driven by the total score of cardiopulmonary exercise testing as described in claim 5, wherein, The optimal cutoff value for the ventilation / CO2 slope (V̇E / V̇CO2 slope) is 31.

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7. A prognostic stratification system for interstitial lung disease driven by the total score of cardiopulmonary exercise testing as described in claim 2, wherein, This cardiovascular response indicator includes peak oxygen pulse and heart rate recovery (HRR) 1 minute after exercise.

8. A prognostic stratification system for interstitial lung disease driven by the total score of cardiopulmonary exercise testing as described in claim 7, wherein, The optimal cutoff value for the peak oxygen pulse was 7.6 mL / beat, and the optimal cutoff value for the heart rate recovery (HRR) 1 minute after exercise was 14 beats / min.

9. A prognostic stratification system for interstitial lung disease driven by the total score of cardiopulmonary exercise testing as described in any of claims 2 to 8, wherein, The processing device further includes a feature reduction filtering module to remove peak oxygen uptake (VO2) data from the cardiopulmonary exercise test data.

10. A prognostic stratification system for interstitial lung disease driven by the total score of cardiopulmonary exercise testing as described in claim 1, wherein, The first logic state is a digital signal 1, the second logic state is a digital signal 0, and the arithmetic summation is performed by one of the arithmetic summation modules included in the processing device.

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