Production intermediate
A novel production method for oxoisoquinoline derivatives improves yield and reduces solvent use, addressing the challenges of scaling up Compound (A) production by using intermediates like Compound (Ia) and specific chemical reactions.
US20260209236A1Pending Publication Date: 2026-07-23CARNA BIOSCI
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Patent Information
- Authority / Receiving Office
- US · United States
- Patent Type
- Applications(United States)
- Current Assignee / Owner
- CARNA BIOSCI
- Filing Date
- 2022-12-23
- Publication Date
- 2026-07-23
AI Technical Summary
Technical Problem
The existing method for producing oxoisoquinoline derivatives, such as Compound (A), is difficult to scale up industrially due to low operability, low yield, and high solvent use, necessitating a more efficient and cost-effective production process.
Method used
A novel production method involving intermediates like Compound (Ia) and specific chemical reactions, including oxetanylation, chlorination, deprotection, and bromination, to produce Compound (A) with improved yield and reduced solvent use.
Benefits of technology
The new method enables the production of Compound (A) in higher yields and at lower costs, making it suitable for industrial-scale pharmaceutical production.
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Abstract
The following formula (Ia):or a salt thereof provided by the present invention is useful as a production intermediate for producing the Compound (A) having a BTK inhibitory action.
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