COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE CONJUGATES WITH PROTEIN AND METHODS OF USE THEREOF

Description

The invention relates to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide-protein conjugate, wherein each conjugate comprises a polysaccharide of an S. pneumoniae serotype conjugated to a carrier protein, wherein the S. pneumoniae serotypes are as defined herein. In some embodiments, at least one of the polysaccharide-protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In other embodiments, each of the polysaccharide-protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Methods for inducing a protective immune response in a human patient are also provided, comprising administering the multivalent immunogenic compositions of the invention to the patient.Multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and / or pneumococcal diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimens that provide complementary protection for patients vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.