PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV-INFECTED CELLS.

Description

THIS DISCLOSURE RELATES TO PYRIMIDONE DERIVATIVES OF FORMULA II AND THEIR USE FOR SELECTIVELY INACTIVATING HIV-INFECTED GAG-POL-EXPRESSING CELLS WITHOUT CONCOMITANT CYTOTOXICITY WITH RESPECT TO HIV-UNDIFFERENTIATED CELLS, AND FOR THE TREATMENT OR PROPHYLAXIS OF HIV INFECTION, OR FOR THE TREATMENT, PROPHYLAXIS, OR DELAY OF THE ONSET OR PROGRESSION OF AIDS OR AIDS-RELATED COMPLEX (ARC). (30) US 63 / 025278 US, 05 / 15 / 2020; US 62 / 953223 US, 12 / 24 / 2019; US 62 / 863199 US, 06 / 18 / 2019; (51) (73) PFIZER INC. Address: 235 East 42nd Street, New York 10017, Country: UNITED STATES OF AMERICA CTXT PTY LTD.Address: 305 Grattan Street, Parkville, Melbourne, 3000 Country: AUSTRALIA (72) YLVA ELISABET BERGMAN BOZIKIS; SCOTT CHANNING SUTTON; SAMANTHA ELIZABETH GREASLEY; ROBERT LOUIS HOFFMAN; ROBERT ARNOLD KUMPF; PEI-PEI KUNG; PAUL FRANCIS RICHARDSON; PAUL ANTHONY STUPPLE; OLEG BRODSKY; MICHELLE ANG CAMERINO (74) GONZALEZ YANES, SEBASTIAN (54) BENZISOXAZOLE SULFONAMIDE DERIVATIVES (57) THE PRESENT INVENTION RELATES TO THE COMPOUNDS OF FORMULA (I) OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, WHEREIN RING A, R1-R8, AND YN ARE DEFINED HEREIN. NOVEL BENZISOXAZOLE SULFONAMIDE DERIVATIVES ARE USEFUL FOR THE TREATMENT OF ABNORMAL CELL GROWTH, SUCH AS CANCER, IN PATIENTS. ADDITIONAL MODALITIES RELATED TO PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS AND METHODS OF USE OF THE COMPOUNDS AND COMPOSITIONS IN THE TREATMENT OF ABNORMAL CELL GROWTH IN PATIENTS.