IMMUNOGENIC COMPOSITIONS AGAINST ENTERIC DISEASES AND METHODS FOR THEIR PREPARATION

Description

THIS DISCLOSURE RELATES TO NOVEL IMMUNOGENIC MONOVALENT AND MULTIVALENT POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE COMPOSITIONS COMPRISING A POLYSACCHARIDE SELECTED FROM THE SALMONELLA S. TYPHI, S. PARATYPHI A, S. TYPHIMURIUM AND S. ENTERITIDIS SEROVALS AND IMPROVED ALTERNATIVE METHODS OF POLYSACCHARIDE FERMENTATION, POLYSACCHARIDE PURIFICATION, POLYSACCHARIDE-PROTEIN CONJUGATION AND STABLE FORMULATION. This disclosure also refers to methods for inducing an immune response in subjects against diseases related to Salmonella Typhi and / or for reducing or preventing diseases related to Salmonella Typhi and non-Typhi in subjects using the compositions described herein. The vaccine delivers bactericidal antibodies and is useful for the prevention of gastroenteritis, enteric fever, and typhoid fever.