4-(2-fluorine-4-methoxy-5-3-(((1-methyloxychlorobutyl)methyl)carbamoyl)bioxychloro[2,2,1]heptane-2-yl)carbamoyl)phenoxy)-1-methyloxychlorohexane-1-carboxylic acid derivatives and similar compounds used as RXFP1 modulators for the treatment of heart failure

Abstract

The invention relates to the derivative of 4-(2-fluoro-4-methoxy-5-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexan-1-carboxylic acid and analogous compound with formula (I) used as RXFP1 modulators for the treatment of heart failure, heart failure with preserved ejection fraction, heart failure with intermediate ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute renal injury. The invention relates to the crystalline form of this compound. The example compound is (A).

Description

[0001] 4-(2-FLUORO-4-METHOXY-5-3-(((1-METHYLCYCLOBUTYL) METHYL)CARBAMOYL)BICYCLO[2.2.1]HEPTAN-2-YL)CARBAMOYL) PHEN0XY)-1-METHYLCYCL0HEXANE-1 -CARBOXYLIC ACID DERIVATIVES AND SIMILAR COMPOUNDS AS RXFP1 MODULATORS FOR THE TREATMENT OF HEART FAILURE

[0002] FIELD

[0003] Described in this specification are compounds (including salts thereof) that are modulators of RXFP1, uses of such compounds, compositions containing such compounds, intermediates useful in processes for preparing such compounds, and processes for preparing such compounds using such intermediates.

[0004] BACKGROUND

[0005] Relaxin is a pleiotropic hormone known to mediate systemic haemodynamic and renal adaptive changes during pregnancy. Relaxin has also been shown to have anti-fibrotic properties and to have beneficial effects in heart failure e.g. with acute decompensated heart failure (ADHF). Heart failure is associated with significant morbidity and mortality. It is characterized by complex tissue remodelling involving increased cardiomyocyte death and interstitial fibrosis. Relaxin activates a number of signalling cascades which have been shown to be beneficial in the setting of ischemia-reperfusion and heart failure. These signalling pathways include activation of the phosphoinositide 3 -kinase pathway and activation of the nitric oxide signalling pathway (Bathgate RA et al. (2013) Physiol. Rev. 93(1): 405-480; Mentz RJ et al. (2013) 4m. Heart J. 165(2): 193-199; Tietjens J et al. (2016) Heart 102: 95-99; Wilson SS et al. (2015) Pharmacology 35: 315-327).

[0006] Clinical trials have been conducted using unmodified recombinant human Relaxin-2, serelaxin. Continuous intravenous administration of serelaxin to hospitalized patients improved the markers of cardiac, renal and hepatic damage and congestion (Felker GM et al. (2014) J. Am. Coll. Cardiol. 64(15): 1591-1598; Metra M et al. (IQX^ J. Am. Coll. Cardiol. 61(2): 196-206; Teerlink JR et al. (2013) Lancet 381(9860): 29-39). However, due to the rapid clearance of serelaxin from the patients' circulation, the therapeutic effects were limited and the positive effects rapidly disappeared once intravenous injection stopped. Additionally, approximately one third of the patients experienced a significant blood pressure drop (>40 mm Hg) after receiving serelaxin intravenously, with the consequence that the dose had to be reduced by half or even more.

[0007] The cognate receptor for human relaxin is RXFP1 and is a well-validated pharmacologically important GPCR family 1c member whose activation by the hormone relaxin is associated with hemodynamic, anti-fibrotic and anti-inflammatory properties (Halls ML et al., (2015), Pharmacol Rev. 67(2): 389-440). Small-molecule modulators of RXFP1 have been sought as relaxin mimetics. For example, Marugan, J. J., et al., WO2013 / 165606A1; Xiao J et al. (2013) Nat. Commun. 4: 1953; and McBride A et al. (2017) Scientific Reports 7: 10806 discuss small-molecule modulators of RXFP1.

[0008] Despite the foregoing, a need continues to exist for further compounds that are modulators of RXFP1 which may make the compounds especially promising for development as therapeutic agents. The compound(s) of the invention may also exhibit improved modulation of RXFP1 in comparison with other known RXFP1 modulators. The compound(s) of the invention may also exhibit favourable pharmacokinetic profiles (for example, lower intrinsic clearance) and / or advantageous physical properties (for example, higher aqueous solubility) in comparison with other known RXFP1 modulators. Therefore, such compound(s) may be especially useful in the treatment of disease states in which modulation of RXFP1 is beneficial.

[0009] SUMMARY

[0010] Briefly, this specification describes, in part, a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein

[0011] Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; or a 4- to 10-membered cycloalkenyl; R7is selected from -H, -F, -CH3and -OCH3; each R8is independently selected from C1-4alkyl substituted with 0-3 -F substituents; C1- 4 alkoxy; -OH; -F; and -COO( C1-4alkyl); p is 0, 1 or 2; 5 Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; a 4- to 10-membered cycloalkenyl; or a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; each R9is independently selected from C1-4alkyl, C1-4alkoxy, -halo and -OH; 10 q is 0, 1 or 2; R1is selected from -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, - C(NH)NH2, -SO2NH2, -NHSO2Me, , , , X is selected from a bond, -CH2-, -O-, -S-, -CH2O- and -OCH2-;15Y is selected from C2-6alkylene substituted with 0-2 R14substituents; C3-8cycloalkylene substituted with 0-2 R14substituents; C5-8cycloalkenylene substituted with 0-2 R14substituents; 5- to 8-membered heterocycloalkylene having 1-3 heteroatoms independently selected from oxygen and sulfur and substituted with 0-2 R14substituents; phenylene substituted with 0-2 R14substituents; 5- or 6-membered heteroarylene having 1-3 heteroatoms independently selected 20 from nitrogen, oxygen and sulfur and substituted with 0-2 R14substituents; and R14is selected from C1-3alkyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; C1-3alkoxy substituted with 0-3 -F substituents; cyclopropyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe; and -25NMe2; Z is selected from a bond; C1-3alkylene substituted with 0-2 substituents selected from - Me, -NH2, -NHMe and -NMe2; C2-4heteroalkylene having one heteroatom selected from nitrogen and oxygen and substituted with 0-2 substituents selected from -Me, -NH2, -NHMe and -NMe2; C3-4cycloalkylene; and -CH=CH-; R5is selected from -H, -Me and -F; R6is -(CR10R11)nR12; n is 0, 1 or 2; R10and R11are each independently selected from -H, -Me and -F, or R10and R11together with the carbon to which they are attached form cyclopropyl; R12is selected from C3-8alkyl substituted with 0-5 substituents selected from -OH, -F, - CN, and C1-4alkoxy; C3-10cycloalkyl substituted with 0-4 R13substituents; 5- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-4 R13substituents; phenyl substituted with 0-3 substituents selected from - halo, C1-4alkyl substituted with 0-3 -F substituents, C3-5cycloalkyl, -CN, -SF5, -OMe, -OCH2F, - OCHF2, -OCF3and -SO2CF3; 6-membered heteroaryl having 1-2 nitrogen heteroatoms and substituted with 1-3 substituents selected from -halo, -SF5, -CF3, -OCF3and -SO2CF3; each R13is independently selected from -OH; -F; -CN; C1-4alkoxy substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; and C1-4alkyl substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; U, V and W are each independently selected from C and N; provided that when U is N, R2is absent; when V is N, R3is absent; and when W is N, R4is absent; and wherein (i) R2, R3and R4are each independently selected from -H, -halo, -CN, C1-4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1-4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and - Me; or (ii) U and V are each C; R2and R3, together with the atoms to which they are attached, form a 5- or 6- membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-3 -Me substituents; and R4is selected from -H, -halo, -CN, C1-4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1-4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me; or (iii) V and W are each C; R3and R4, together with the atoms to which they are attached, form a 5- or 6- membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-3 -Me substituents; and R2is selected from -H, -halo, -CN, C1-4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1-4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me. This specification also describes, in part, a pharmaceutical composition which comprises a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient. This specification also describes, in part, a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in therapy. This specification also describes, in part, a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury. This specification also describes, in part, the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury. This specification also describes, in part, a method for treating a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury in a subject in need of such treatment, which comprises administering to said subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

[0012] This specification also describes, in part, an Intermediate compound (as described herein), or a salt thereof. This specification also describes, in part, a process for preparing a compound of Formula

[0013] (I), or pharmaceutically acceptable salt thereof, using an Intermediate compound (as described herein), or a salt thereof.

[0014] Further aspects of Applicant's invention will be apparent to one skilled in the art from reading this specification.

[0015] DESCRIPTION OF ILLUSTRATIVE EMBODIMENTS

[0016] Many embodiments are detailed throughout the specification and will be apparent to a reader skilled in the art. The specification is not to be interpreted as being limited to any particular embodiment s) described herein. In an embodiment there is provided a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having

[0017] 1-2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; or a 4- to 10-membered cycloalkenyl; R7is selected from -H, -F, -CH3and -OCH3; each R8is independently selected from C1-4alkyl substituted with 0-3 -F substituents; C1-4alkoxy; -OH; -F; and -COO(C1-4alkyl); p is 0, 1 or 2; Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; a 4- to 10-membered cycloalkenyl; or a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; each R9is independently selected fromC1-4alkyl,C1-4alkoxy, -halo and -OH; q is 0, 1 or 2; R1is selected from -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, - , X is selected from a bond, -CH2-, -O-, -S-, -CH2O- and -OCH2-; Y is selected from C2-6alkylene substituted with 0-2 R14substituents; C3-8cycloalkylene substituted with 0-2 R14substituents; C5-8cycloalkenylene substituted with 0-2 R14substituents; 5- to 8-membered heterocycloalkylene having 1-3 heteroatoms independently selected from oxygen and sulfur and substituted with 0-2 R14substituents; phenylene substituted with 0-2 R14substituents; 5- or 6-membered heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-2 R14substituents; and R14is selected from C1-3 alkyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; C1-3alkoxy substituted with 0-3 -F substituents; cyclopropyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe; and - NMe2; Z is selected from a bond; C1-3alkylene substituted with 0-2 substituents selected from - Me, -NH2, -NHMe and -NMe2; C2-4heteroalkylene having one heteroatom selected from nitrogen and oxygen and substituted with 0-2 substituents selected from -Me, -NH2, -NHMe and -NMe2; C3-4cycloalkylene; and -CH=CH-; R5is selected from -H, -Me and -F; R6is -(CR10R11)nR12; n is 0, 1 or 2; R10and R11are each independently selected from -H, -Me and -F, or R10and R11together with the carbon to which they are attached form cyclopropyl; R12is selected from C3-8alkyl substituted with 0-5 substituents selected from -OH, -F, - CN, and C1-4alkoxy; C3-10cycloalkyl substituted with 0-4 R13substituents; 5- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-4 R13substituents; phenyl substituted with 0-3 substituents selected from - halo, C1-4alkyl substituted with 0-3 -F substituents, C3-5cycloalkyl, -CN, -SF5, -OMe, -OCH2F, - OCHF2, -OCF3and -SO2CF3; 6-membered heteroaryl having 1-2 nitrogen heteroatoms and substituted with 1-3 substituents selected from -halo, -SF5, -CF3, -OCF3and -SO2CF3; each R13is independently selected from -OH; -F; -CN; C1-4alkoxy substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; and C1-4alkyl substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; U, V and W are each independently selected from C and N; provided that when U is N, R2is absent; when V is N, R3is absent; and when W is N, R4is absent; and wherein (i) R2, R3and R4are each independently selected from -H, -halo, -CN, C1-4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1-4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and - Me; or (ii) U and V are each C; R2and R3, together with the atoms to which they are attached, form a 5- or 6- membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-3 -Me substituents; and

[0018] R4is selected from -H, -halo, -CN, C1-4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1-4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me; or (iii) V and W are each C;

[0019] R3and R4, together with the atoms to which they are attached, form a 5- or 6- membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-3 -Me substituents; and

[0020] R2is selected from -H, -halo, -CN, C1.4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me.

[0021] The following embodiments of moieties A, Ring B, Ring C, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, n, p, q, r, U, V, W, X, Y, and Z may be applied, alone or in combination, to the descriptions of the compounds of Formula (I) provided herein.

[0022]

[0023]

[0024] Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; or a 4- to 10-membered cycloalkenyl.

[0025] Ring B is a monocyclic 5- to 7-membered cycloalkyl optionally bridged with C1.3alkylene; a monocyclic 5- to 7-membered heterocycloalkyl having 1-2 heteroatoms independently selected from nitrogen and oxygen and optionally bridged with C1.3alkylene; a monocyclic 5- to 7-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen and optionally bridged with C1.3alkylene; or a monocyclic 5- to 7-membered cycloalkenyl optionally bridged with C1.3alkylene.

[0026] Ring B is a 4- to 10-membered cycloalkyl, or a 4- to 10-membered cycloalkenyl.

[0027] Ring B is a 5- to 8-membered cycloalkyl, or a 5- to 8-membered cycloalkenyl.

[0028] Ring B is a monocyclic 5- to 7-membered cycloalkyl optionally bridged with C1.3alkylene; or a monocyclic 5- to 7-membered cycloalkenyl optionally bridged with C1.3alkylene.

[0029] Ring B is cyclohexyl optionally bridged with C1.2alkylene, or cyclohexenyl optionally bridged with C1.2alkylene.

[0030] Ring B is cyclohexyl 1,4-bridged with C1.2alkylene, or cyclohexenyl 1,4-bridged with C1-2alkylene.

[0031] Ring B is bicyclo[2.2.1]heptanyl or bicyclo[2.2.1]hept-2-enyl.

[0032] Ring B is bicyclo[2.2. l]heptanyl.

[0033] R7is selected from -H, -F, -CH3and -OCH3.

[0034] R7is selected from -H and -F.

[0035] R7is -H. each R8is independently selected from C1.4alkyl substituted with 0-3 -F substituents; C1- 4 alkoxy; -OH; -F; and -COO(C1-4alkyl). each R8is independently selected from C1.2alkyl substituted with 0-3 -F substituents; C1- 2 alkoxy; -OH; and -F. each R8is independently selected from C1.2alkyl substituted with 0-3 -F substituents; and -F. each R8is independently selected from -Me and -F. p is 0, 1 or 2. p is 0 or 1. p is 0.

[0036] Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; a 4- to 10-membered cycloalkenyl; or a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen. Ring C is phenyl; a monocyclic 5- or 6-membered heteroaryl having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur; a monocyclic 4- to 7-membered cycloalkenyl optionally bridged with C1.3alkylene; or a monocyclic 4- to 7-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen and optionally bridged with C1.3alkylene.

[0037] Ring C is a monocyclic 5- to 7-membered cycloalkenyl optionally bridged with C1.2alkylene; or a monocyclic 5- to 7-membered heterocycloalkenyl having 1 oxygen heteroatom and optionally bridged with C1.2alkylene.

[0038] Ring C is a mono- or poly-cyclic 6- to 10-membered aryl.

[0039] Ring C is phenyl.

[0040] Ring C is not phenyl. each R9is independently selected from C1.4alkyl, C1.4alkoxy, -halo and -OH. each R9is independently selected from C1.2alkyl, C1.2alkoxy, -halo and -OH. q is 0, 1 or 2. q is 0 or 1. q is 0.

[0041] R1is selected from -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, -

[0042] R1is -COOH or a bioisotere of a carboxylic acid such as tetrazolyl. Such bioisoteres of carboxylic acids will be apparent to a person of skill in the art.

[0043] R1is selected from -

[0044] R1is -COOH. X is selected from a bond, -CH2-, -O-, -S-, -CH2O- and -OCH2-.

[0045] X is selected from a bond, -CH2-, -O-, -CH2O- and -OCH2-.

[0046] X is selected from a bond, -CH2-, and -O-.

[0047] X is selected from -CH2- and -O-.

[0048] X is -O-.

[0049] Y is selected from C2-6alkylene substituted with 0-2 R14substituents; C3-8cycloalkylene substituted with 0-2 R14substituents; C5-8 cycloalkenylene substituted with 0-2 R14substituents; 5- to 8-membered heterocycloalkylene having 1-3 heteroatoms independently selected from oxygen and sulfur and substituted with 0-2 R14substituents; phenylene substituted with 0-2 R14substituents; 5- or 6-membered heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-2 R14substituents; and

[0050] Y is selected from C2-6alkylene substituted with 0-1 R14substituents; C3-8cycloalkylene substituted with 0-1 R14substituents; C5-8 cycloalkenylene substituted with 0-1 R14substituents; 5- to 8-membered heterocycloalkylene having 1-3 heteroatoms independently selected from oxygen and sulfur and substituted with 0-1 R14substituents; phenylene substituted with 0-1 R14substituents; 5- or 6-membered heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-1 R14substituents; and

[0051] Y is selected from C2-4alkylene substituted with 0-2 R14substituents; C3-8cycloalkylene substituted with 0-2 R14substituents; and 5- to 8-membered heterocycloalkylene having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-2 R14substituents. Y is selected from C2-4alkylene substituted with 0-1 R14substituents; C3-8cycloalkylene substituted with 0-1 R14substituents; and 5- to 8-membered heterocycloalkylene having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-1 R14substituents.

[0052] Y is selected from C4-6cycloalkylene substituted with 0-1 R14substituents; and 5- or 6- membered heterocycloalkylene having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-1 R14substituents.

[0053] Y is C3-8cycloalkylene substituted with 0-2 R14substituents.

[0054] Y is C4-6cycloalkylene substituted with 0-2 R14substituents.

[0055] Y is C3-8cycloalkylene substituted with 0-1 R14substituents.

[0056] Y is C4-6cycloalkylene substituted with 0-1 R14substituents.

[0057] Y is cyclohexylene substituted with 0-2 R14substituents.

[0058] Y is cyclohexylene substituted with 0-1 R14substituents.

[0059] Y is cyclohexylene substituted with 1 R14substituent.

[0060] Optionally, in any of the embodiments of Y described herein, the X and Z substituents are bonded to Y such that, where there are sufficient ring or chain atoms in Y, the X and Z substituents are not in a geminal or vicinal configuration.

[0061] r is 1, 2 or 3. r is 1 or 2. r is 2.

[0062] R14is selected from C1.3alkyl substituted with 0-1 substituents selected from -OH, -OMe, -F and -CN; C1.3alkoxy substituted with 0-1 -F substituents; cyclopropyl substituted with 0-1 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe; and - NMe2.

[0063] R14is selected from C1.2alkyl substituted with 0-1 substituents selected from -OH, -OMe, -F and -CN; C1.2alkoxy substituted with 0-1 -F substituents; cyclopropyl substituted with 0-1 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe; and - NMe2.

[0064] R14is selected from -H, -Me, -Et, -F, -OH, =O, -OMe, -OEt, -CF3, -CH2OH, -CH2OMe, - CN, -CH2CN, -NH2, -NHMe and -NMe2.

[0065] R14is -H.

[0066] R14is not -H.

[0067] R14is -Me. Z is selected from a bond; C1-3alkylene substituted with 0-2 substituents selected from - Me, -NH2, -NHMe and -NMe2; C2-4heteroalkylene having one heteroatom selected from nitrogen and oxygen and substituted with 0-2 substituents selected from -Me, -NH2, -NHMe and -NMe2; C3-4cycloalkylene; and -CH=CH-. Z is selected from a bond; C1-2alkylene substituted with 0-1 substituents selected from - Me, -NH2, -NHMe and -NMe2; C2-3heteroalkylene having one heteroatom selected from nitrogen and oxygen and substituted with 0-1 substituents selected from -Me, -NH2, -NHMe and -NMe2; C3-4cycloalkylene; and -CH=CH-. Z is selected from a bond, -CH2-, -CH2CH2-, -OCH2-, -CH2O-, -C(CH3)2O-, -CH2CH2O-, -CH2CH2CH2O-, -CH2NH-, -CH(NH2)-, -CH(NMe2)-, -CH2CH(NMe2)-, -CH(NMe2)CH2-, - CH2CH(NH2)-, -CH(NH2) CH2-, -CH=CH-, Z is selected from a bond, -CH2-, -CH2CH2-, and -CH2O-. Z is a bond. R5is selected from -H, -Me and -F. R5is -H. R6is -(CR10R11)nR12. R6is -(CR10R11)R12. R6is -(CH2)R12. R6is -R12. R6is selected from R6is selected from and . R6is n is 0, 1 or 2. n is 0 or 1. n is 0. n is 1.

[0068] R10and R11are each independently selected from -H, -Me and -F, or R10and R11together with the carbon to which they are attached form cyclopropyl.

[0069] R10and R11are each independently selected from -H, -Me and -F.

[0070] R10and R11are each -H.

[0071] R12is selected from C3-8alkyl substituted with 0-5 substituents selected from -OH, -F, - CN, and C1.4alkoxy; C3-10cycloalkyl substituted with 0-4 R13substituents; 5- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-4 R13substituents; phenyl substituted with 0-3 substituents selected from - halo, C1.4alkyl substituted with 0-3 -F substituents, C3-5cycloalkyl, -CN, -SF5, -OMe, -OCH2F, - OCHF2, -OCF3and -SO2CF3; 6-membered heteroaryl having 1-2 nitrogen heteroatoms and substituted with 1-3 substituents selected from -halo, -SF5, -CF3, -OCF3and -SO2CF3;

[0072] R12is selected from C3-8alkyl substituted with 0-3 substituents selected from -OH, -F, - CN, and C1.4alkoxy; C3-10cycloalkyl substituted with 0-3 R13substituents; and 5- to 10- membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-3 R13substituents.

[0073] R12is selected from C4-6alkyl substituted with 0-3 substituents selected from -F, -CN, and C1-2alkoxy; C4-6cycloalkyl substituted with 0-3 R13substituents; and 5- to 6-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-3 R13substituents.

[0074] R12is selected from C4-6alkyl substituted with 0-2 substituents selected from -F, -CN, and C1-2alkoxy; C4-6cycloalkyl substituted with 0-1 R13substituents; and 5- to 6-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-1 R13substituents. R12is selected from C4-6alkyl substituted with 0-3 -F substituents; and C4-6cycloalkyl substituted with 0-3 substituents selected from -F and -Me.

[0075] R12is selected from C3-6alkyl substituted with 0-3 -F substituents; and C3-6cycloalkyl substituted with 0-3 substituents selected from -F and -Me.

[0076] R12is selected from C3-6alkyl substituted with 0-3 -F substituents; and C3-6cycloalkyl substituted with -F or -Me.

[0077] R12is selected from tert-butyl substituted with 0-3 -F substituents; cyclobutyl substituted with 0-2 substituents selected from -F and -Me; and bicyclo[l.l. l]pentanyl substituted with 0-2 substituents selected from -F and -Me.

[0078] R12is selected from tert-butyl substituted with 0-3 -F substituents; cyclobutyl substituted with 0-2 substituents selected from -F and -Me; and bicyclo[l.l. l]pentanyl substituted with 0-2 substituents selected from -F and -Me.

[0079] R12is selected from tert-butyl substituted with 0-3 -F substituents; cyclobutyl substituted with 0-1 substituents selected from -F and -Me; and bicyclo[l.l. l]pentanyl substituted with 0-2 substituents selected from -F and -Me.

[0080] R12is selected from

[0081] R12is selected from phenyl substituted with 0-3 substituents selected from -halo, C1.4alkyl substituted with 0-3 -F substituents, C3-5cycloalkyl, -CN, -SF5, -OMe, -OCH2F, -OCHF2, - OCF3and -SO2CF3; 6-membered heteroaryl having 1-2 nitrogen heteroatoms and substituted with 1-3 substituents selected from -halo, -SF5, -CF3, -OCF3and -SO2CF3; R12is selected from phenyl substituted with 1-2 substituents selected from -halo, C1-4alkyl substituted with 0-3 -F substituents, C3-5cycloalkyl, -CN, -SF5, -OMe, -OCH2F, -OCHF2, - OCF3and -SO2CF3. selected from -halo, -Me, -CF3and -CN.

[0082] R12is selected from each R13is independently selected from -OH; -F; -CN; C1.4alkoxy substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; and C1.4alkyl substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt. each R13is independently selected from -F; -CN; C1.2alkoxy substituted with 0-1 substituents selected from -F, -OMe and -OEt; and C1.2alkyl substituted with 0-1 substituents selected from -F, -OMe and -OEt. each R13is independently selected from -F; -CN; C1.4alkoxy; and C1.4alkyl. each R13is independently selected from -F; C1.2alkoxy; and C1.2alkyl. each R13is independently selected from -F; -OMe; and -Me. each R13is -F. each R13is -Me.

[0083] U, V and W are each independently selected from C and N; provided that when U is N, R2is absent; when V is N, R3is absent; and when W is N, R4is absent.

[0084] U, V and W are each C.

[0085] R2, R3and R4are each independently selected from -H, -halo, -CN, C1.4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me.

[0086] R2is selected from -H, -halo, -CN, C1.4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe.

[0087] R2is selected from -H, -halo, -CN, C1.2alkyl substituted with 0-3 -F substituents, C1.2alkyl substituted with 0-1 -OMe substituents, and C3-4cycloalkyl substituted with 0-1 substituents selected from -F and -OMe.

[0088] R2is selected from -H, -halo, -CN, C1.2alkyl substituted with 0-3 -F substituents, C1.2alkyl substituted with 0-1 -OMe substituents, and cyclopropyl.

[0089] R2is not -H.

[0090] R2is -CN or -F.

[0091] R2is -CN.

[0092] R2is -F.

[0093] R3is selected from -H, -halo, -CN, C1.4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe.

[0094] R3is selected from -H, -halo, -CN, C1.2alkyl substituted with 0-3 -F substituents, C1.2alkyl substituted with 0-1 -OMe substituents, and C3-4cycloalkyl substituted with 0-1 substituents selected from -F and -OMe.

[0095] R3is selected from -H, -halo, -CN, C1.2alkyl substituted with 0-3 -F substituents, C1.2alkyl substituted with 0-1 -OMe substituents, and cyclopropyl.

[0096] R3is -H.

[0097] R4is selected from -H, -F, C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me.

[0098] R4is selected from -H, -F, and C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe.

[0099] R4is selected from -F and C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe.

[0100] R4is selected from -F and C1.3alkoxy substituted with 0-2 substituents selected from -F and -OMe. R4is selected from -F and C1.3alkoxy substituted with 0-2 substituents selected from -F and -OMe.

[0101] R4is C1.3alkoxy substituted with 0-2 substituents selected from -F and -OMe.

[0102] R4is -OMe or -OEt.

[0103] R4is not -H.

[0104] R4is selected from -F and -OMe.

[0105] R4is -OMe.

[0106] R2and R3, together with the atoms to which they are attached, form a 5- or 6-membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-3 -Me substituents; and U and V are each C.

[0107] R3and R4, together with the atoms to which they are attached, form a 5- or 6-membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-3 -Me substituents; and V and W are each C. Optionally, R3and R4are selected such that the ring containing R3, R4, V and W is and wherein said ring is optionally substituted with 0-2 -Me substituents. Optionally, R3and R4are selected such that the ring containing R3, R4, V and W is

[0108] In one embodiment, R2is -CN; R3is -H; R4is -OMe; and R5is -H.

[0109] In one embodiment, R2is -F; R3is -H; R4is -OMe; and R5is -H. Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; or a 4- to 10-membered cycloalkenyl;

[0110] R7is selected from -H, -F, -CH3and -OCH3; each R8is independently selected from C1.4alkyl substituted with 0-3 -F substituents; C1- 4 alkoxy; -OH; -F; and -COO(C1-4alkyl); p is 0, 1 or 2;

[0111] Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; a 4- to 10-membered cycloalkenyl; or a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; each R9is independently selected from C1.4alkyl, C1.4alkoxy, -halo and -OH; q is 0, 1 or 2;

[0112] R1is selected from -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, -

[0113] X is selected from a bond, -CH2-, -O-, -S-, -CH2O- and -OCH2-;

[0114] Y is selected from C2-6 alkylene substituted with 0-2 R14substituents; C3-8cycloalkylene substituted with 0-2 R14substituents; C5-8cycloalkenylene substituted with 0-2 R14substituents; 5- to 8-membered heterocycloalkylene having 1-3 heteroatoms independently selected from oxygen and sulfur and substituted with 0-2 R14substituents; phenylene substituted with 0-2 R14substituents; 5- or 6-membered heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-2 R14substituents; and R14is selected from C1.3alkyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; C1.3alkoxy substituted with 0-3 -F substituents; cyclopropyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe; and - NMe2;

[0115] Z is selected from a bond; C1.3alkylene substituted with 0-2 substituents selected from - Me, -NH2, -NHMe and -NMe2; C2-4heteroalkylene having one heteroatom selected from nitrogen and oxygen and substituted with 0-2 substituents selected from -Me, -NH2, -NHMe and -NMe2; C3-4cycloalkylene; and -CH=CH-;

[0116] R5is selected from -H, -Me and -F;

[0117] R6is -(CR10Ru)nR12; n is 0, 1 or 2;

[0118] R10and R11are each independently selected from -H, -Me and -F, or R10and R11together with the carbon to which they are attached form cyclopropyl;

[0119] R12is selected from C3-8alkyl substituted with 0-5 substituents selected from -OH, -F, - CN, and C1.4alkoxy; C3-10cycloalkyl substituted with 0-4 R13substituents; 5- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-4 R13substituents; phenyl substituted with 0-3 substituents selected from - halo, C1.4alkyl substituted with 0-3 -F substituents, C3-5 cycloalkyl, -CN, -SF5, -OMe, -OCH2F, - OCHF2, -OCF3and -SO2CF3; 6-membered heteroaryl having 1-2 nitrogen heteroatoms and substituted with 1-3 substituents selected from -halo, -SF5, -CF3, -OCF3and -SO2CF3; each R13is independently selected from -OH; -F; -CN; C1.4alkoxy substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; and C1.4alkyl substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt;

[0120] U, V and W are each independently selected from C and N; provided that when U is N, R2is absent; when V is N, R3is absent; and when W is N, R4is absent;

[0121] R2and R3are each independently selected from -H, -halo, -CN, C1.4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me; and R4is selected from -F and C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe; optionally R4is C1.4alkoxy substituted with 0-3 substituents selected from -F and - OMe; optionally R4is -OMe.

[0122] In one embodiment

[0123] Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; or a 4- to 10-membered cycloalkenyl;

[0124] R7is -H; each R8is independently selected from C1-4alkyl substituted with 0-3 -F substituents; C1- 4 alkoxy; -OH; -F; and -COO(C1-4alkyl); p is 0, 1 or 2, optionally p is 0;

[0125] Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; a 4- to 10-membered cycloalkenyl; or a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; each R9is independently selected from C1-4alkyl, C1-4alkoxy, -halo and -OH; q is 0, 1 or 2, optionally q is 0;

[0126] R1is -COOH;

[0127] X is selected from a bond, -CH2-, -O-, -S-, -CH2O- and -OCH2-; optionally X is -O-;

[0128] R14is selected from C1.3alkyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; C1.3alkoxy substituted with 0-3 -F substituents; cyclopropyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe; and - NMe2;

[0129] Z is selected from a bond; C1.3alkylene substituted with 0-2 substituents selected from - Me, -NH2, -NHMe and -NMe2; C2-4heteroalkylene having one heteroatom selected from nitrogen and oxygen and substituted with 0-2 substituents selected from -Me, -NH2, -NHMe and -NMe2; C3-4cycloalkylene; and -CH=CH-; optionally Z is a bond;

[0130] R5is selected from -H, -Me and -F, optionally R5is -H;

[0131] R6is -(CR10Ru)nR12; n is 0, 1 or 2;

[0132] R10and R11are each independently selected from -H, -Me and -F, or R10and R11together with the carbon to which they are attached form cyclopropyl;

[0133] R12is selected from C4-6alkyl substituted with 0-3 substituents selected from -F, -CN, and C1-2alkoxy; C4-6cycloalkyl substituted with 0-3 R13substituents; and 5- to 6-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-3 R13substituents; or selected from -halo, -Me, -CF3and -CN; each R13is independently selected from -OH; -F; -CN; C1.4alkoxy substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; and C1.4alkyl substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt;

[0134] U, V and W are each independently selected from C and N; provided that when U is N, R2is absent; when V is N, R3is absent; and when W is N, R4is absent;

[0135] R2and R3are each independently selected from -H, -halo, -CN, C1.4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me; and R4is selected from -F and C1-4alkoxy substituted with 0-3 substituents selected from -F and -OMe; optionally R4is C1.4alkoxy substituted with 0-3 substituents selected from -F and - OMe; optionally R4is -OMe.

[0136] In one embodiment,

[0137] Ring B is a 5- to 8-membered cycloalkyl, or a 5- to 8-membered cycloalkenyl;

[0138] R7is selected from -H and -F; each R8is independently selected from C1.2alkyl substituted with 0-3 -F substituents; and

[0139] -F; p is 0 or 1; optionally p is 0;

[0140] R1is selected from - X is -O-; r is 1 or 2;

[0141] R14is selected from C1.2alkyl substituted with 0-1 substituents selected from -OH, -OMe, -F and -CN; C1.2alkoxy substituted with 0-1 -F substituents; cyclopropyl substituted with 0-1 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe; and - NMe2;

[0142] Z is a bond;

[0143] R5is -H;

[0144] R6is -(CR10Ru)nR12; n is 0 or 1; optionally n is 1;

[0145] R10and R11are each independently selected from -H, -Me and -F, or R10and R11together with the carbon to which they are attached form cyclopropyl; R12is selected from C4-6alkyl substituted with 0-3 substituents selected from -F, -CN, and C1-2alkoxy; C4-6cycloalkyl substituted with 0-3 R13substituents; and 5- to 6-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-3 R13substituents; or substituents selected from -halo, -Me, -CF3and -CN; each R13is independently selected from -F; -CN; C1.2alkoxy substituted with 0-1 substituents selected from -F, -OMe and -OEt; and C1.2alkyl substituted with 0-1 substituents selected from -F, -OMe and -OEt;

[0146] U, V and W are each C;

[0147] R2is selected from -H, -halo, -CN, C1.2alkyl substituted with 0-3 -F substituents, C1.2alkyl substituted with 0-1 -OMe substituents, and cyclopropyl; optionally R2is -F or -CN;

[0148] R3is selected from -H, -halo, -CN, C1.2alkyl substituted with 0-3 -F substituents, C1.2alkyl substituted with 0-1 -OMe substituents, and cyclopropyl; optionally R3is -H;

[0149] R4is selected from -F and C1.4alkoxy substituted with 0-3 substituents selected from -F and -OMe; optionally R4is C1.4alkoxy substituted with 0-3 substituents selected from -F and - OMe; optionally R4is -OMe.

[0150] In an embodiment, there is provided a compound of Formula (Ila) or Formula (lib):

[0151] (Formula Ila) (Formula lib) or a pharmaceutically acceptable salt thereof, wherein R2and R6are as defined for Formula (I).

[0152] In an embodiment, there is provided a compound of Formula (Ila) or Formula (lib), or a pharmaceutically acceptable salt thereof, wherein R2is -F or -CN; and R6is selected from

[0153] In an embodiment, there is provided a compound of Formula (Ila) or Formula (lib), or a pharmaceutically acceptable salt thereof, wherein

[0154] In an embodiment, there is provided a compound of Formula (Ila) or Formula (lib), or a pharmaceutically acceptable salt thereof, wherein

[0155] In an embodiment, there is provided a compound of Formula (Ila) or Formula (lib), or a pharmaceutically acceptable salt thereof, wherein

[0156] In an embodiment, there is provided a compound of Formula (Ila) or Formula (lib), or a pharmaceutically acceptable salt thereof, wherein In an embodiment, there is provided a compound of Formula (Illa) or Formula (Illb): (Formula Illa) (Formula Illb) or a pharmaceutically acceptable salt thereof, wherein R2and R6are as defined for Formula (I).

[0157] In an embodiment, there is provided a compound of Formula (Illa) or Formula (Illb), or a pharmaceutically acceptable salt thereof, wherein R2is -F or -CN; and R6is selected from

[0158] In an embodiment, there is provided a compound of Formula (Illa) or Formula (Illb), or a pharmaceutically acceptable salt thereof, wherein

[0159] In an embodiment, there is provided a compound of Formula (Illa) or Formula (Illb), or a pharmaceutically acceptable salt thereof, wherein

[0160] In an embodiment, there is provided a compound of Formula (Illa) or Formula (Illb), or a pharmaceutically acceptable salt thereof, wherein

[0161] In an embodiment, there is provided a compound of Formula (Illa) or Formula (Illb), or a pharmaceutically acceptable salt thereof, wherein

[0162] In an embodiment, there is provided a compound of Formula (Illa), or a pharmaceutically acceptable salt thereof, wherein R2is -F or -CN; and R6is selected from CH3

[0163] In an embodiment, there is provided a compound of Formula (IVa) or Formula (IVb):

[0164] or a pharmaceutically acceptable salt thereof, wherein R2and R6are as defined for

[0165] Formula (I). In an embodiment, there is provided a compound of Formula (IVa) or Formula (IVb), or a pharmaceutically acceptable salt thereof, wherein R2is -F or -CN; and R6is selected from

[0166] In an embodiment, the compound of Formula (I) is pharmaceutically acceptable salt thereof.

[0167] In an embodiment, the compound of Formula (I) is

[0168] pharmaceutically acceptable salt thereof.

[0169] In an embodiment, the compound of Formula (I) is pharmaceutically acceptable salt thereof.

[0170] In an embodiment, the compound of Formula (I) is pharmaceutically acceptable salt thereof. In an embodiment, the compound of Formula (I) is pharmaceutically acceptable salt thereof. In an embodiment, the compound of Formula (I) is pharmaceutically acceptable salt thereof.

[0171] In an embodiment, the compound of Formula (I) is

[0172] pharmaceutically acceptable salt thereof.

[0173] In an embodiment, the compound of Formula (I) is pharmaceutically acceptable salt thereof.

[0174] In an embodiment, the compound of Formula (I) is

[0175] In an embodiment, the compound of Formula (I) is

[0176]

[0177] In an embodiment, the compound of Formula (I) is

[0178] In an embodiment, the compound of Formula (I) is

[0179] In an embodiment, a compound is provided that is any one of the compounds from COMPOUND LIST A, or a pharmaceutically acceptable salt thereof. In an embodiment, a compound is provided that is any one of the compounds from COMPOUND LIST A.

[0180] In an embodiment, the compound of Formula (I) is selected from the compounds of COMPOUND LIST A, or pharmaceutically acceptable salts thereof. In an embodiment, the compound of Formula (I) is selected from the compounds of

[0181] COMPOUND LIST A.

[0182] COMPOUND LIST A:

[0183] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0184] 4-(5-((3-((cyclobutylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0185] 4-(2-fluoro-4-(fluoromethoxy)-5 -((3 -((( 1 - methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0186] 4-(2-fluoro-4-methyl-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0187] 6-(2-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)spiro[3 ,3]heptane-2-carboxylic acid;

[0188] 4-(2-fluoro-5-((3-(isopropylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0189] 4-(5-((3-(cyclohexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0190] 4-(5-((3-((3-(difluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro- 4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0191] 4-(2-fluoro-5-((3-((3-(fluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0192] 4-(2-fluoro-4-methoxy-5-((3-((2-(trifluoromethyl)pyridin-4-yl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0193] 4-(2-fluoro-4-methoxy-5-((3-((5-(trifluoromethyl)pyridin-2-yl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0194] 4-(2-fluoro-4-methoxy-5-((3-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0195] 4-(2-fluoro-4-methoxy-5 -((3 -((4-

[0196] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0197] 4-(2-fluoro-4-methoxy-5-((3-((perfluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0198] 4-(2-fluoro-5 -((3 -((3 -fluoro-5-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid; 4-(2-fluoro-5-((3-((2-fluoro-3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0199] 4-(5-((3-((3-cyano-4-methylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro- 4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0200] 4-(2-fluoro-4-methoxy-5-((3-((3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0201] 4-(2-fluoro-5-((3-((4-fluoro-3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0202] 4-(5-((3-((3,5-bis(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0203] 4-(5-((3-((4-bromo-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)- 2-fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0204] 4-(2-fluoro-4-methoxy-5 -((3 -((2-methyl-3 -

[0205] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-

[0206] 1 -carboxylic acid;

[0207] 4-(5-((3-((3-chlorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0208] 4-(5-((3-((2-chloro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-

[0209] 2-fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0210] 4-(5-((3-((3-bromo-4-cyanophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0211] 4-(5-((3-((4-cyano-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)- 2-fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0212] 4-(2-fluoro-5-((3-((3-fluoro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0213] 4-(5-((3-((5-chloropyridazin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0214] 4-(2-fluoro-4-methoxy-5-((3-((6-(trifluoromethyl)pyrimidin-4- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0215] 4-(2-fluoro-4-methoxy-5-((3-((4-(trifluoromethyl)pyrimidin-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0216] 4-(5-((3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0217] 4-(2-fluoro-5-((3-(isobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0218] 4-(2-fluoro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0219] 4-(5-((3-((3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0220] 4-(5-((3-((2,2-dimethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0221] 4-(2-fluoro-4-methoxy-5 -((3 -((3 , 3 ,3 -trifluoro-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((l-(l-methylcyclopropyl)ethyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0222] 4-(5-((3-((2,4-dimethylpentan-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro- 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0223] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0224] 4-(2-fluoro-4-methoxy-5-((3-((3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0225] 4-(5-((3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0226] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0227] 4-(5-((3-((2-cyano-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro- 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0228] 4-(2-fluoro-5-((3-(((l-(fluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0229] 4-(2-fluoro-5-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0230] 4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0231] 4-(2-fluoro-5-((4-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)tetrahydrofuran-3- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0232] 3-(5-((4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N- neopentylbicyclo[2.2.1]heptane-2-carboxamide;

[0233] 4-(5-((3-chloro-2-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0234] 4-(2-fluoro-4-methoxy-5-((2-((3-methylbutan-2- yl)carbamoyl)cy cl opentyl)carbamoyl)phenoxy)-l-methylcy cl ohexane-1 -carboxylic acid;

[0235] 4-(2-fluoro-5-((2-(((l-(fluoromethyl)cyclopropyl)methyl)carbamoyl)cyclopentyl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0236] 4-(2-fluoro-4-methoxy-5-((2-(neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0237] 4-(5-((2-((2,2-dimethylbutyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-

[0238] 1 -methylcyclohexane- 1 -carboxylic acid;

[0239] 4-(5-((2-((2-ethylbutyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0240] 4-(5-((2-((3,3-dimethylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0241] 4-(5-((2-((2,4-dimethylpentan-3-yl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0242] 4-(2-fluoro-4-methoxy-5-((2-((l-(l- methylcy cl opropyl)ethyl)carbamoyl)cy cl opentyl)carbamoyl)phenoxy)-l-methylcy cl ohexane-1 - carboxylic acid; 4-(2-fluoro-4-methoxy-5 -((2-((( 1 - methylcyclohexyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0243] 4-(2-fluoro-5-((2-(isobutylcarbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0244] 4-(2-fluoro-4-methoxy-5 -((2-((( 1 - methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0245] 4-(2-fluoro-4-methoxy-5 -((2-((( 1 - methylcyclopropyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-methylcyclohexane-

[0246] 1 -carboxylic acid;

[0247] 4-(5-((2-((2-cyano-2-methylpropyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0248] 4-(2-fluoro-4-methoxy-5 -((2-((3 , 3 ,3 -trifluoro-2,2- dimethylpropyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 - carboxylic acid;

[0249] 4-(2-cyano-5-((3-((cyclopropylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0250] 4-(2-cyano-5-((3-((l-cyanocyclopropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0251] 4-(2-cyano-4-methoxy-5-((3-((3-methylcyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0252] 4-(2-cyano-5-((3-(((l-hydroxycyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0253] 4-(2-cyano-5-((3-(((l-(hydroxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0254] 4-(2-cyano-5-((3-((2-hydroxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0255] 4-(2-cyano-5-((3-((l-fluoro-2-methylpropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0256] 4-(2-cyano-5-((3-(((l-isopropylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0257] 4-(2-cyano-4-methoxy-5-((3-(((l-

[0258] (methoxymethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0259] 4-(2-cyano-4-methoxy-5-((3-(((l-methoxycyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-

[0260] 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0261] 4-(5-((3-((adamantan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0262] 4-(2-cyano-5-((3-((cycloheptylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0263] 4-(2-cyano-4-methoxy-5-((3-(((l-propylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((2,2,3,3- tetramethylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0264] 4-(2-cyano-5-((3-((2-(isopropylamino)-2-oxoethyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0265] 4-(2-cyano-5-((3-(((l-ethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-

[0266] 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0267] 4-(2-cyano-5-((3-(((3,3-dimethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0268] 4-(2-cyano-5-((3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0269] 4-(2-cyano-5-((3-((2-fluoro-3-hydroxypropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-

[0270] 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0271] 4-(2-cyano-4-methoxy-5-((3-((l-methylcyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0272] 4-(5-((3-(butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-

[0273] 1 -methylcyclohexane- 1 -carboxylic acid;

[0274] 4-(2-cyano-5-((3-(((l-fluorocyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0275] 4-(2-cyano-5-((3-(((l-cyanocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0276] 4-(2-cyano-5-((3-(((l-fluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0277] 4-(2-cyano-5-((3-(((l-(fluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0278] 4-(2-cyano-5-((3-((2,2-difluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0279] 4-(2-cyano-5-((3-((2-fluoro-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-

[0280] 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0281] 4-(2-cyano-4-methoxy-5-((3-(((l-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0282] 4-(5-((3-(tert-butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0283] 4-(2-cyano-4-methoxy-5-((3-((l-methylcyclopropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0284] 4-(2-cyano-5-((3-(((4,4-difluoro-l-hydroxycyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0285] 4-(2-cyano-4-methoxy-5-((3-((2,2,3,3,3-pentafluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0286] 4-(2-cyano-5-((3-(((l-hydroxycycloheptyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0287] 4-(2-cyano-5-((3-(((l-(ethoxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((l-methylcycloheptyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0288] 4-(2-cyano-5-((3-(((l-isobutylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0289] 4-(2-cyano-5-((3-(((4-cyanocyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0290] 4-(2-cyano-4-methoxy-5-((3-((2-phenylpropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0291] 4-(2-cyano-5-((3-(((l-(hydroxymethyl)cyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0292] 4-(2-cyano-5-((3-(((4-fluorotetrahydro-2H-pyran-4-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0293] 4-(2-cyano-4-methoxy-5-((3-(((l-methoxycyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0294] 4-(5-((3-([l,l'-bi(cyclopropan)]-l-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano- 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0295] 4-(2-cyano-5-((3-((3-hydroxyadamantan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)- 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0296] 4-(2-cyano-5-((3-(((4-(difluoromethyl)pyrimidin-2-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0297] 4-(2-cyano-4-methoxy-5-((3-(propylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0298] 4-(2-cyano-5-((3-(hexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0299] 4-(2-cyano-4-methoxy-5-((3-((2-phenylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0300] 4-(2-cyano-5-((3-((3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0301] 4-(2-cyano-5-((3-((l-cyclohexylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0302] 4-(2-cyano-5-((3-(cyclohexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0303] 4-(2-cyano-5-((3-((3-isopropoxypropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0304] 4-(2-cyano-5-((3-((3,4-difluorobenzyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0305] 4-(2-cyano-4-methoxy-5-((3-(((3-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0306] 4-(2-cyano-4-methoxy-5-((3-(tert-pentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0307] 4-(2-cyano-4-methoxy-5-((3-((3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0308] 4-(2-cyano-5-((3-((4,4-dimethylcyclohexyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((2-methoxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0309] 4-(2-cyano-5-((3-((3,3-dimethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0310] 4-(2-cyano-5-((3-((2-fluoro-2-phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0311] 4-(2-cyano-5-((3-((3-cyclopropylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0312] 4-(2-cyano-5-((3-((2-cyclopropylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0313] 4-(2-cyano-4-methoxy-5-((3-((2-(2,2,2- trifluoroethyl)cyclohexyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0314] 4-(2-cyano-5-((3-((3-fluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0315] 4-(2-cyano-5-((3-((2,5-dimethylbenzyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0316] 4-(2-cyano-4-methoxy-5-((3-(((tetrahydro-2H-pyran-4- yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0317] 4-(2-cyano-5-((3-((3-hydroxy-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0318] 4-(2-cyano-4-methoxy-5-((3-((3-methylbenzyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0319] 4-(2-cyano-5-((3-(cyclopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0320] 4-(2-cyano-4-methoxy-5-((3-((l-phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0321] 4-(5-((3-(bicyclo[l .1. l]pentan-l-ylcarbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0322] 4-(2-fluoro-4-methoxy-5-((2-(neopentylcarbamoyl)phenyl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0323] 4-(2-fluoro-4-methoxy-5 -((2-((( 1 - methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0324] 4-(5-((3-((3-ethylpentan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0325] 4-(2-fluoro-5-((3-(((4-fluorotetrahydro-2H-pyran-4-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-

[0326] 2 -yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0327] 3-(5-((4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-((4- fluorotetrahydro-2H-pyran-4-yl)methyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0328] 3-(2-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclobutane- 1 -carboxylic acid;

[0329] 3-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclobutane- 1 -carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-(((l-methylcy cl obutyl)methyl)carbamoyl)pyri din-3 - yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0330] 4-(2-fluoro-4-methoxy-5 -((2-((( 1 - methylcyclobutyl)methyl)carbamoyl)cyclooctyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0331] 4-(2-fluoro-4-methoxy-5-((3-methyl-5-(((l-methylcyclobutyl)methyl)carbamoyl)isothiazol-4- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0332] 4-(5-((4-chloro-2-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0333] 4-(2-fluoro-4-methoxy-5-((2-(((l-methylcy cl obutyl)methyl)carbamoyl)thi ophen-3 - yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0334] 4-(5-((5-chloro-2-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0335] 4-(2-fluoro-4-methoxy-5-((2-methyl-6-(((l- methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0336] 4-(5-((5-chloro-2-((cycloheptylmethyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0337] 4-(5-((5-chloro-2-(((l-phenylcyclopropyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0338] 4-(5-((5-chloro-2-(((3-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0339] 4-(5-((5-chloro-2-(((l-fluorocyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0340] 4-(5-((2-(bicyclo[l .1. l]pentan-l-ylcarbamoyl)-5-chlorophenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0341] 4-(5-((5-chloro-2-((3-fluoro-3-methylbutan-2-yl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0342] 4-(5-((5-chloro-2-(tert-pentylcarbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0343] 4-(5-((5-chloro-2-((2-fluoro-2-methylpropyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0344] 4-(5-((5-chloro-2-((2-cyclopropylpropan-2-yl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0345] 4-(2-cyano-5-((2-((3-fluorobenzyl)carbamoyl)-5-methylphenyl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0346] 4-(2-cyano-5-((2-((2-ethylbutyl)carbamoyl)-5-methylphenyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0347] 4-(2-cyano-4-methoxy-5-((5-methyl-2-(pentan-3-ylcarbamoyl)phenyl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0348] 4-(2-cyano-4-methoxy-5-((5-methyl-2-((4- methylcyclohexyl)carbamoyl)phenyl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0349] 4-(2-cyano-4-methoxy-5-((5-methyl-2-((3-methylbutan-2- yl)carbamoyl)phenyl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid; 4-(2-cyano-4-methoxy-5-((5-methyl-2-((3- methylcyclobutyl)carbamoyl)phenyl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0350] 4-(2-cyano-5-((2-(((l-fluorocyclobutyl)methyl)carbamoyl)-5-methylphenyl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0351] 4-(5-((2-(bicyclo[l .1. l]pentan-l-ylcarbamoyl)-5-methylphenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0352] 4-(2-cyano-4-methoxy-5-((5-methyl-2-(((l- methylcyclopropyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0353] 4-(2-fluoro-4-methoxy-5-((3-((4,4,4-trifluorobutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0354] 4-(5-((3-((2-cyclopropylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0355] 4-(5-((3-(cyclobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0356] 4-(5-((3-(bicyclo[l .1. l]pentan-l-ylcarbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0357] 4-(2-fluoro-5-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0358] 4-(2-fluoro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0359] 4-(5-((3-((4-(difluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro- 4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0360] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[0361] 4-(2-fluoro-4-methoxy-5-((3-((4-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[0362] 4-(5-((3-((2,6-difluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0363] 4-(2-fluoro-5-((3-((3-iodophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0364] 4-(5-((3-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)- 2-fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0365] 4-(2-fluoro-4-methoxy-5-((3-((3,4,5-trifluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0366] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -methyl-5 -

[0367] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane- 1 -carboxylic acid;

[0368] 4-(5-((3-((3-(tert-butyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0369] 4-(5-((3-((3-cyclopropylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid; 4-(5-((3-((3-cyano-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)- 2-fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0370] 4-(2-fluoro-4-methoxy-5 -((3 -((4-methyl-3 -

[0371] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane- 1 -carboxylic acid;

[0372] 4-(2-fluoro-4-methoxy-5-((3-((3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0373] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -methoxy-5 -

[0374] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane- 1 -carboxylic acid;

[0375] 4-(5-((3-((3-(difluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0376] 4-(2-fluoro-5-((3-((3-isopropylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0377] 4-(5-((3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0378] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0379] 4-(5-((3-((3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0380] 4-(2-fluoro-4-methoxy-5-((3-(phenylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0381] 4-(2-fluoro-4-methoxy-5-((3-((2-methylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0382] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)benzyl)-l -methylcyclohexane- 1 -carboxylic acid;

[0383] 4-(2-fluoro-5-((3-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1- m ethylcyclohexane- 1 -carboxylic acid;

[0384] 4-(4-(difluoromethoxy)-2-fluoro-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0385] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0386] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0387] 2'-fluoro-4'-methoxy-5'-((3-((3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[0388] 2'-fluoro-4'-methoxy-5'-((3-((4-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[0389] 4-(5-((2,4-dimethyl-6-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0390] 4-(5-((4,5-dimethyl-2-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; 4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclohex-l-en-l- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0391] 4-(2-fluoro-5-((2-((4-fluoro-3 -(trifluoromethyl)phenyl)carbamoyl)cy cl opent- 1 -en- 1 - yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0392] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)naphthalen-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0393] 4-(2-fluoro-4-methoxy-5-((4-methyl-2-(((l- methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0394] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)pyrazolo[l,5- a]pyrimidin-2-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0395] 3-(4-methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)propanoic acid;

[0396] 3-(5-((lH-pyrazol-4-yl)methyl)-4-fluoro-2-methoxybenzamido)-N-(3-

[0397] ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0398] 2-(4-(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0399] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-lH- pyrazol-l-yl)acetic acid;

[0400] 1 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0401] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-lH- pyrazole-5-carboxylic acid;

[0402] 1 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0403] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-lH- pyrazole-3 -carboxylic acid;

[0404] 2-(4-methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)benzyl)benzoic acid;

[0405] 2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-

[0406] 5-en-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[0407] 2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept- 5-en-2-yl)carbamoyl)-[l,l'-biphenyl]-3-carboxylic acid;

[0408] 2'-fluoro-3,4'-dimethoxy-5'-((3-((3-

[0409] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0410] 2,2'-difluoro-4'-methoxy-5'-((3-((3-

[0411] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0412] 5 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0413] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)nicotinic acid;

[0414] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0415] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)- lH-pyrrole-2-carboxylic acid;

[0416] 2'-fluoro-4,4'-dimethoxy-5'-((3-((3-

[0417] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid; 2',4-difluoro-4'-methoxy-5'-((3-((3-

[0418] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[0419] 2',3-difluoro-4'-methoxy-5'-((3-((3-

[0420] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0421] 2,2'-difluoro-4'-methoxy-5'-((3-((3-

[0422] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[0423] 2-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0424] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)acetic acid;

[0425] 2-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0426] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-2-yl)acetic acid;

[0427] 2',3-difluoro-4'-methoxy-5'-((3-((3-

[0428] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0429] 3 -(5 -(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0430] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrimidin-2-yl)propanoic acid;

[0431] 3 -(5 -(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0432] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrazin-2-yl)propanoic acid;

[0433] 3-(dimethylamino)-2'-fluoro-4'-methoxy-5'-((3-((3-

[0434] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0435] 4-((2'-fluoro-4'-methoxy-5'-((3-((3-

[0436] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)oxy)butanoic acid;

[0437] 2'-fluoro-4'-methoxy-3,5-dimethyl-5'-((3-((3-

[0438] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0439] 2-(6-(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0440] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2,3- dihydrobenzofuran-3 -yl)acetic acid;

[0441] (5-(2-fluoro-4-methoxy-5-((3-((3-

[0442] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrimidin-2-yl)glycine;

[0443] 2-((5 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0444] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridin-2-yl)oxy)acetic acid;

[0445] 3 -(6-(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0446] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbam oyl)phenyl)pyri din-3 -yl)propanoic acid; 2-((2'-fluoro-4'-methoxy-5'-((3-((3-

[0447] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)oxy)-2-methylpropanoic acid;

[0448] 2-((2'-fluoro-4'-methoxy-5'-((3-((3-

[0449] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,l'- biphenyl]-4-yl)oxy)acetic acid;

[0450] 3 -(2-(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0451] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)thiazol-5-yl)propanoic acid;

[0452] 3-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0453] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[0454] 3 -(6-(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0455] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridazin-3-yl)propanoic acid;

[0456] 2' -fluoro-4' -m ethoxy -3 -methyl - 5'-((3-((3-

[0457] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0458] 2'-fluoro-3-hydroxy-4'-methoxy-5'-((3-((3-

[0459] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0460] 3 -(5 -(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0461] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridin-2-yl)propanoic acid;

[0462] 3-(2'-fluoro-3,4'-dimethoxy-5'-((3-((3-

[0463] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[0464] (E)-3 -(5 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0465] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridin-2-yl)acrylic acid;

[0466] 2-(5 -(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0467] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbam oyl)phenyl)pyridin-2-yl)cy cl opropane-1 -carboxylic acid;

[0468] 2-(5 -(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0469] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrazin-2-yl)cyclopropane- 1 -carboxylic acid;

[0470] 3-(6-fluoro-4-methoxy-4'-sulfamoyl-[l,r-biphenyl]-3-carboxamido)-N-(3- ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0471] 3-(4'-(2-amino-l,3-dihydroxypropan-2-yl)-6-fluoro-4-methoxy-[l,r-biphenyl]-3-carboxamido)- N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0472] 3-(4'-(3-amino-4-hydroxy-3-(hydroxymethyl)butyl)-3',6-difluoro-4-methoxy-[l,r-biphenyl]-3- carboxamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0473] 3 -(4-(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0474] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2- oxopyridin- 1 (2H)-yl)propanoic acid; 2'-fluoro-4'-methoxy-5'-((3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0475] 3 -(4-(2-fluoro-4-m ethoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-lH- pyrazol-l-yl)propanoic acid;

[0476] 2'-fluoro-4'-methoxy-5'-((3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2. l]heptan-2 -yl)carbamoyl)-2, 3,4,5- tetrahydro-[l, l'-biphenyl]-4-carboxylic acid;

[0477] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0478] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)cyclohexane- 1 -carboxylic acid;

[0479] 6-fluoro-4-methoxy-N3-(3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-

[0480] 5-en-2-yl)-[l,r-biphenyl]-3,4'-dicarboxamide;

[0481] 2-(4-(2-fluoro-4-m ethoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)- lH-pyrazol-l-yl)acetic acid;

[0482] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0483] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid;

[0484] 2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-

[0485] 5-en-2-yl)carbamoyl)-[l,l'-biphenyl]-2-carboxylic acid;

[0486] 5 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0487] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid;

[0488] 2-(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)oxazole-4-carboxylic acid;

[0489] 5 -(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)pyrazine-2-carboxylic acid;

[0490] 2-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0491] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)isonicotinic acid;

[0492] 6-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0493] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)nicotinic acid;

[0494] 6-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0495] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid;

[0496] 5 -(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)pyrimidine-2-carboxylic acid;

[0497] 2-(2'-fluoro-4'-methoxy-5'-((3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)acetic acid; 3-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0498] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)propanoic acid;

[0499] 3-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0500] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[0501] 5 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0502] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiophene-3-carboxylic acid;

[0503] 5 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0504] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiophene-2-carboxylic acid;

[0505] 2-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0506] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiazole-4-carboxylic acid;

[0507] 2-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0508] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiazole-5-carboxylic acid;

[0509] 1-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0510] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)cyclopropane- 1 -carboxylic acid;

[0511] 2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0512] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[0513] 2-amino-3 -(2'-fluoro-4' -methoxy-5 '-((3 -((3 -

[0514] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[0515] 2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0516] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)propanoic acid;

[0517] 2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0518] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)acetic acid;

[0519] 2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-((3-((3-

[0520] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)acetic acid;

[0521] 2'-fluoro-5'-((3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5- en-2-yl)carbamoyl)-4'-methoxy-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[0522] 2'-fluoro-5'-((3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5- en-2-yl)carbamoyl)-4'-methoxy-[ 1 , 1 '-biphenyl]-3 -carboxylic acid;

[0523] 2'-fluoro-5'-((3-((3-fluoro-5-(pentafluoro-X6-sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5- en-2-yl)carbamoyl)-4'-methoxy-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[0524] 2'-fluoro-4'-methoxy-5'-((2-((3-

[0525] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-4- carboxylic acid; 2'-fluoro-4'-methoxy-5'-((2-((3-

[0526] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-3- carboxylic acid;

[0527] 2'-fluoro-4'-methoxy-5'-((2-((3-

[0528] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[l,r-biphenyl]-4- carboxylic acid;

[0529] 2'-fluoro-4'-methoxy-5'-((2-((3-

[0530] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[l,r-biphenyl]-3- carboxylic acid;

[0531] 2'-fluoro-4'-methoxy-5'-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[0532] 2'-fluoro-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[0533] 2',4'-difluoro-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[0534] 2'-fluoro-5'-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-4'-methoxy-[l, l'-biphenyl]-4-carboxylic acid;

[0535] 2'-fluoro-5'-((3-((3-fluoro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-4'-methoxy-[l, l'-biphenyl]-4-carboxylic acid;

[0536] 5'-((3-((3-cyano-4-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-2'-fluoro-

[0537] 4'-methoxy-[l,l'-biphenyl]-4-carboxylic acid;

[0538] 5'-((3-((3-cyano-5-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-2'-fluoro-

[0539] 4'-methoxy-[l,l'-biphenyl]-4-carboxylic acid;

[0540] 2'-fluoro-4'-methoxy-5'-((3-((l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[0541] 2'-fluoro-4'-methoxy-5'-((3-((l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[0542] 2'-fluoro-4-hydroxy-4'-methoxy-5'-((3-((3-

[0543] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[0544] 2-(2'-fluoro-4'-methoxy-5'-((2-((3-

[0545] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-3- yl)acetic acid;

[0546] 3-(2'-fluoro-4'-methoxy-5'-((2-((3-

[0547] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-3- yl)propanoic acid;

[0548] 2-(2'-fluoro-4'-methoxy-5'-((2-((3-

[0549] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-4- yl)acetic acid;

[0550] 3-(2'-fluoro-4'-methoxy-5'-((2-((3-

[0551] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-4- yl)propanoic acid;

[0552] 3 -(5 -(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0553] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)- l,3,4-thiadiazol-2-yl)propanoic acid; 3 -(2-(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0554] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrimidin-5-yl)propanoic acid;

[0555] 3-(6-fluoro-4-methoxy-4'-(lH-tetrazol-5-yl)-[l,l'-biphenyl]-3-carboxamido)-N-(3-

[0556] ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0557] 3-(6-fluoro-4-methoxy-4'-(2-sulfamoylethyl)-[l,l'-biphenyl]-3-carboxamido)-N-(3-

[0558] ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0559] 2'-fluoro-4'-methoxy-5'-((2-((3-

[0560] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)phenyl)carbamoyl)-[l,r-biphenyl]-4-carboxylic acid;

[0561] 2-((2'-cyano-4'-methoxy-5'-((3-((3-

[0562] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)oxy)acetic acid;

[0563] 2-((2'-fluoro-4'-methoxy-5'-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-

[0564] [1,1 '-biphenyl]-4-yl)oxy)acetic acid;

[0565] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)-7- oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0566] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)-7- oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-(hydroxymethyl)cyclohexane-l-carboxylic acid;

[0567] 4-(2-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)-7- oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0568] 4-(5-((7-(tert-butoxycarbonyl)-3-(((l-methylcyclobutyl)methyl)carbamoyl)-7- azabicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0569] 4-(2-fluoro-4-methoxy-5 -((4-methoxy-2-((3 -

[0570] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0571] 4-(2-fluoro-4-methoxy-5-((4-methoxy-2-

[0572] (neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-(hydroxymethyl)cyclohexane-l- carboxylic acid;

[0573] 4-(2-fluoro-4-methoxy-5-((4-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H- pyran-3-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0574] 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H- pyran-4-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0575] 4-(2-fluoro-4-methoxy-5-((4-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-

[0576] 3 -yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0577] 4-(2-fluoro-5-((4-((4-fluoro-3-(pentafluoro-X6-sulfaneyl)phenyl)carbamoyl)tetrahydrofuran-3- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0578] 4-(2-fluoro-4-methoxy-5-((4-(neopentylcarbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0579] 4-(2-fluoro-4-methoxy-5-((2-(neopentylcarbamoyl)cyclobutyl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid; 4-(2-fluoro-5-((2-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane- 1 -carboxylic acid;

[0580] 4-(2-cyano-4-methoxy-5-((2-(((l- methylcy cl obutyl)methyl)carbamoyl)cy cl obutyl)carbamoyl)phenoxy)- 1-methylcy cl ohexane-1- carboxylic acid;

[0581] 4-(2-fluoro-5-((4-((4-fluoro-3-(pentafluoro-X6-sulfaneyl)phenyl)carbamoyl)tetrahydro-2H- pyran-3-yl)carbamoyl)-4-m ethoxyphenoxy)- 1-methylcy cl ohexane-1 -carboxylic acid;

[0582] 4-(2-fluoro-4-methoxy-5-((4-(((l-methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0583] 4-(2-fluoro-4-methoxy-5 -((2-((3 -

[0584] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0585] 4-(2-fluoro-5-((2-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0586] 4-(2-fluoro-4-methoxy-5 -((2-((3 -

[0587] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cycloheptyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0588] 4-(2-fluoro-5 -((2-fluoro-2-((3 -

[0589] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0590] 4-(2-fluoro-4-methoxy-5-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-

[0591] 3 -yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0592] 4-(2-fluoro-4-methoxy-5-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H- pyran-3-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0593] 4-(2-fluoro-4-methoxy-5-((2-methoxy-5-((3-

[0594] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0595] 4-(2-cyano-4-methoxy-5-((2-(((l- methylcy cl obutyl)methyl)carbamoyl)cy cl opentyl)carbamoyl)phenoxy)- 1-methylcy cl ohexane-1 - carboxylic acid;

[0596] 4-(2-cyano-4-methoxy-5-((2-(((l- methylcy cl obutyl)methyl)carbamoyl)cy cl ohexyl)carbamoyl)phenoxy)- 1-methylcy cl ohexane-1 - carboxylic acid;

[0597] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -(hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[0598] 4-(2-fluoro-4-methoxy-5 -((3 -((( 1 -

[0599] (trifluoromethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)- l-(hydroxymethyl)cy cl ohexane-1 -carboxylic acid;

[0600] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0601] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-

[0602] (hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[0603] 4-(4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-(trifluoromethyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid; 4-(2-(difluoromethyl)-4-methoxy-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0604] 4-(3-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0605] 4-(4-methoxy-2-methyl-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0606] 4-(2-ethyl-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0607] 4-(4-cyano-2-fluoro-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; l-methyl-4-((l-methyl-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-lH-indazol-7-yl)oxy)cyclohexane-l -carboxylic acid;

[0608] 1-methyl-4-((l-methyl-6-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-lH-indazol-4-yl)oxy)cyclohexane-l -carboxylic acid;

[0609] 4-(2-fluoro-4-(methoxymethyl)-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0610] 4-(4-methoxy-3-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0611] 4-(5-((3-((3-fluorobicyclo[l.l.l]pentan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-

[0612] 4-methoxy-2-m ethylphen oxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0613] 4-(2-ethyl-5-((3-((3-fluorobicyclo[l.l.l]pentan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0614] 4-(4-ethoxy-2-fluoro-5-((3-((3-fluorobicyclo[l .1. l]pentan-l-yl)carbamoyl)bicyclo[2.2. l]heptan-

[0615] 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0616] 4-(4-ethoxy-2-fluoro-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; l-ethyl-4-(2-fluoro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0617] 4-(2-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0618] 4-(2-cyano-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0619] 4-(3-fluoro-5-((3-((3-fluorobicyclo[l.l.l]pentan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0620] 4-(2-fluoro-4-(2-methoxyethoxy)-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0621] 4-(2-chloro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0622] 4-(2,4-difluoro-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; 4-(5-((2,3-dihydroxy-5-((3-

[0623] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0624] 4-(2-fluoro-4-methoxy-5-((5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-4H- cyclopentafd] [ 1 ,3 ]dioxol-4-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0625] 4-(2-fluoro-5-((2-hydroxy-5-((3-

[0626] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0627] 4-(4-chloro-2-fluoro-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0628] 4-(2-cyclopropyl-4-methoxy-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0629] 4-(2-fluoro-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0630] 4-(2-cyano-4-fluoro-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0631] 4-(4-methoxy-2-(methoxymethyl)-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0632] 4-(3-chloro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0633] 4-(3-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0634] 4-(4-methoxy-3-methyl-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; l-methyl-4-((7-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2,3-dihydrobenzofuran-5-yl)oxy)cyclohexane-l-carboxylic acid; l-methyl-4-((8-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)quinolin-6-yl)oxy)cyclohexane- 1 -carboxylic acid;

[0635] 4-(2-chloro-4-fluoro-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0636] 4-(2-chloro-4-methoxy-5 -((3 -((3,3,3 -trifluoro-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0637] 4-(2-chloro-5-((3 -((3 -fluorobicyclof 1.1.1 ]pentan- 1 -yl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0638] 4-(2-chloro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; l-fluoro-4-(2-fluoro-4-methoxy-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid; l-fluoro-4-(2-fluoro-4-methoxy-5-((3-((3-

[0639] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]hept-5-en-

[0640] 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0641] 3-(4-fluoro-2-methoxy-5-((4-methyl-4-(5-oxo-4,5-dihydro-l,2,4-oxadiazol-3- yl)cyclohexyl)oxy)benzamido)-N-((l-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2- carboxamide;

[0642] 3-(4-fluoro-2-methoxy-5-((4-methyl-4-(5-oxo-4,5-dihydro-l,3,4-oxadiazol-2- yl)cyclohexyl)oxy)benzamido)-N-((l-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2- carboxamide;

[0643] 3-(4-fluoro-2-methoxy-5-((4-methyl-4-(lH-tetrazol-5-yl)cyclohexyl)oxy)benzamido)-N-((l- methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0644] 3-(5-((4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-((l- methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0645] 4-(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- hydroxycyclohexane-1 -carboxylic acid;

[0646] 1 -(cy anomethyl)-4-(2-fluoro-4-methoxy-5 -((3 -((( 1 - methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0647] 3-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)bicyclo[3.1 ,0]hexane-6-carboxylic acid;

[0648] 4-(4-methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[0649] 3-(4-methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[0650] 2-(4-methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[0651] 4-(2,4-difluoro-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0652] 5-(2-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)-2,2-dimethylpentanoic acid;

[0653] 4-(2-fluoro-5-((3-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0654] 3-(5-((4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(3-(pentafluoro-X6- sulfaneyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0655] 6-fluoro-4-m ethoxy -N3 -(3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)-[l,r-biphenyl]-3,4'- dicarboxamide;

[0656] 6-(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)hexanoic acid;

[0657] 7 -(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)heptanoic acid; 9-(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)nonanoic acid;

[0658] 4-((2-fluoro-4-methoxy-5-((3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[0659] 4-((2-fluoro-4-methoxy-5-((3-((3-

[0660] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)cyclohexane-l -carboxylic acid;

[0661] 4-((2-fluoro-4-methoxy-5-((3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)bicyclo[2.2.2]octane-l -carboxylic acid;

[0662] 5 -(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid;

[0663] 3 -(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclobutane- 1 -carboxylic acid;

[0664] 3 -(2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0665] 2-((2-fluoro-4-methoxy-5-((3-((3-

[0666] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[0667] 3 -((2-fluoro-4-methoxy-5 -((3 -((3 -

[0668] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[0669] 4-((2-fluoro-4-methoxy-5-((3-((3-

[0670] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[0671] 5 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0672] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)pentanoic acid;

[0673] 2-(4-((2-fluoro-4-methoxy-5 -((3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid;

[0674] 2-(3 -((2-fluoro-4-methoxy-5 -((3 -((3 -

[0675] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)acetic acid;

[0676] 2-(3 -((2-fluoro-4-methoxy-5 -((3 -((3 -

[0677] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid;

[0678] 6-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0679] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)hexanoic acid; 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0680] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)butanoic acid;

[0681] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0682] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0683] 1 -amino-4-(2-fluoro-4-methoxy-5-((3 -((3 -

[0684] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0685] 3-(4-fluoro-2-methoxy-5-((4-(methylsulfonamido)cyclohexyl)oxy)benzamido)-N-(3-

[0686] ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0687] 4-(2-fluoro-4-methoxy-5-((6-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)hexahydro-4,7- methanobenzo[d][l,3]dioxol-5-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0688] 3-(4-fluoro-2-methoxy-5-((4-sulfamoylcyclohexyl)oxy)benzamido)-N-(3-

[0689] ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[0690] 4-(2-bromo-4-methoxy-5-((3-((3-

[0691] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0692] 4-(4-methoxy-2-methyl-5-((3-((3-

[0693] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0694] 4-(4-methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0695] 4-(2-cyano-4-methoxy-5-((3-((3-

[0696] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0697] 4-(2-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0698] 4-(2-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0699] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0700] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en- 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0701] 3 -((2-fluoro-4-methoxy-5 -((3 -((3 -

[0702] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)cyclobutane-l -carboxylic acid;

[0703] 2-(3 -(2-fluoro-4-m ethoxy-5 -((3 -((3 -

[0704] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclobutyl)acetic acid;

[0705] 2-(4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)-l-methylcyclohexyl)acetic acid;

[0706] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -(trifluoromethyl)cy clohexane- 1 -carboxylic acid; 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0707] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- (methoxymethyl)cyclohexane- 1 -carboxylic acid;

[0708] 4-(2-fluoro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -(methoxymethyl)cyclohexane- 1 -carboxylic acid;

[0709] 4-(2-cyano-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)benzoic acid;

[0710] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0711] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[0712] 4-(2-fluoro-4-isopropoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)-l-(methoxycarbonyl)cyclohexane-l-carboxylic acid;

[0713] 4-(2-fluoro-4-isopropoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)-l-(hydroxymethyl)cyclohexane-l -carboxylic acid;

[0714] 4-(5-((l-acetyl-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)piperidin-4-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0715] 4-(2-fluoro-5-((3-((4-fluoro-3-(pentafluoro-X6-sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-

[0716] 5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0717] 4-(2-fluoro-5-((3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-

[0718] 5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0719] 4-(2-fluoro-4-methoxy-5 -((2-((3 -

[0720] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[0721] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0722] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0723] 4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0724] 4-(5-((4,4-difluoro-2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)- 2-fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0725] 4-(5-((5,6-dihydroxy-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-

[0726] 2 -yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0727] 4-(2-fluoro-5-((4-hydroxy-2-((3-

[0728] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0729] 4-(2-fluoro-4-methoxy-5 -((3 -((4-methoxy-3 -

[0730] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0731] 4-(2-fluoro-5-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0732] 3-(5-((4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(4-fluoro-3-

[0733] (trifluoromethyl)phenyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide;

[0734] 3-(5-((4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(4-fluoro-3-

[0735] (trifluoromethyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 4-(2-cyano-4-methoxy-5-((3-((3,3,3-trifluoro-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0736] 4-(5-((3-((2, 2-dimethylcyclopentyl)carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)-2 -fluoro- 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0737] 3 -(2-fluoro-4-methoxy-5 -((3 -((3 -

[0738] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclobutane-1 -carboxylic acid;

[0739] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methoxy cyclohexane- 1 -carboxylic acid;

[0740] 4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -hydroxy cyclohexane- 1 -carboxylic acid;

[0741] 4-(2-fluoro-4-methoxy-5 -((3 -((3 -

[0742] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethoxy cyclohexane- 1 -carboxylic acid;

[0743] 4-(2-fluoro-4-methoxy-5-((4-(neopentylcarbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l- (hydroxymethyl)cyclohexane- 1 -carboxylic acid;

[0744] 4-(2-fluoro-4-methoxy-5-((4-(((l-methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3- yl)carbamoyl)phenoxy)- 1 -(hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[0745] 4-(2-cyano-4-fluoro-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0746] 2'-fluoro-5'-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4'-methoxy-[l, l'-biphenyl]-4-carboxylic acid;

[0747] 4-(2-fluoro-4-methoxy-5-((3-(((l-methoxycyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-

[0748] 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0749] 4-(2-fluoro-4-methoxy-5 -((3 -((( 1 -

[0750] (methoxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0751] 4-(5-((3-(((l-cyanocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0752] 4-(2-fluoro-4-methoxy-5-((3-((3,3,3-trifluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0753] 4-(2-fluoro-4-methoxy-5-((3-((l,l,l-trifluoropropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0754] 4-(5-((3-(cyclobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0755] 4-(5-((3-(cyclopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0756] 4-(5-((3-(bicyclo[l .1. l]pentan-l-ylcarbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0757] 4-(5-((3-(tert-butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0758] 4-(2-fluoro-4-methoxy-5 -((3 -((1,1,1 -trifluoro-2-methylpropan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0759] 4-(2-fluoro-4-methoxy-5-((3-((l-((trifluoromethyl)sulfonyl)pyrrolidin-3- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0760] 4-(2-fluoro-5-((3-((3-fluorobicyclo[l .1 ,l]pentan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0761] 4-(2-fluoro-5-((3-(((l-fluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0762] 4-(2-fluoro-4-methoxy-5-((3-((2-methoxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0763] 4-(2-fluoro-5-((3-((2-hydroxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0764] 4-(2-fluoro-5-((3-((3-hydroxy-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0765] 4-(2-fluoro-4-methoxy-5 -((3 -((( 1 -

[0766] (trifluoromethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-

[0767] 1 -methylcyclohexane- 1 -carboxylic acid;

[0768] 4-(2-fluoro-4-methoxy-5 -((3 -((( 1 -

[0769] (trifluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0770] 4-(5-((3-((3-cyano-3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0771] 4-(5-((3-(((l-ethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-

[0772] 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0773] 4-(2-fluoro-4-methoxy-5-((3-((2,2,3,3,3-pentafluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0774] 4-(5-((3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0775] 4-(5-((3-(((3,3-difluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0776] 4-(2-cyano-5-((3-((3-fluorobicyclo[l.l.l]pentan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid; and

[0777] 4-(2-cyano-5-((3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid.

[0778] In a further embodiment there is provided a compound selected from:

[0779] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0780] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2S,3R,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid; (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((cyclobutylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0781] (lS,4s)-4-(2-fluoro-4-(fluoromethoxy)-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0782] (lS,4s)-4-(2-fluoro-4-methyl-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0783] (2R,4r,6R)-6-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)spiro[3 ,3]heptane-2-carboxylic acid;

[0784] (2S,4s,6S)-6-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)spiro[3 ,3]heptane-2-carboxylic acid;

[0785] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-(isopropylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0786] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(cyclohexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)cyclohexane- 1 -carboxylic acid;

[0787] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3-(difluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0788] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((3-

[0789] (fluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0790] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((2-(trifluoromethyl)pyridin-4- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0791] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((5-(trifluoromethyl)pyridin-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0792] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((4-(trifluoromethyl)pyridin-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0793] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((4-

[0794] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0795] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-

[0796] ((perfluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[0797] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((3-fluoro-5-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0798] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((2-fluoro-3-

[0799] (trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0800] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3-cyano-4-methylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid; (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[0801] (trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0802] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((4-fluoro-3-

[0803] (trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0804] (1 S,4s)-4-(5-(((l S,2R,3 S,4R)-3-((3,5- bis(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0805] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((4-bromo-3-

[0806] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0807] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((2-methyl-3-

[0808] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-

[0809] 1 -carboxylic acid;

[0810] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3-chlorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0811] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((2-chloro-5-

[0812] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0813] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3-bromo-4-cyanophenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0814] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((4-cyano-3-

[0815] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0816] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((3-fluoro-5-

[0817] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0818] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((5-chloropyridazin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0819] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((6-(trifluoromethyl)pyrimidin-4- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0820] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((4-(trifluoromethyl)pyrimidin-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0821] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0822] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-(isobutylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0823] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-

[0824] 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0825] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((R)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-

[0826] 2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0827] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((2,2-dimethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid; (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3,3,3-trifluoro-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0828] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((R)-l-(l- methylcyclopropyl)ethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0829] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((S)-l-(l- methylcyclopropyl)ethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0830] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((2,4-dimethylpentan-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0831] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0832] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((S)-3-methylbutan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0833] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0834] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0835] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((S)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-

[0836] 2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0837] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((R)-3-methylbutan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0838] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((2-cyano-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0839] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-(((l-

[0840] (fluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0841] (lR,4s)-4-(2-fluoro-5-(((lS,2S,3R,4R)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)-7- oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0842] (lS,4s)-4-(2-fluoro-5-(((lR,2R,3S,4S)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)-7- oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0843] (lS,4s)-4-(2-fluoro-5-(((lR,2S)-2-((4-fluoro-3-

[0844] (trifluoromethyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0845] (lR,4s)-4-(2-fluoro-5-(((3S,4R)-4-((4-fluoro-3-

[0846] (trifluoromethyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0847] (lR,2S,3R,4S)-3-(5-(((ls,4S)-4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2- methoxybenzamido)-N-neopentylbicyclo[2.2.1]heptane-2-carboxamide; (1s,4s)-4-(5-((3-chloro-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro- 4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((S)-3-methylbutan-2- yl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylicacid; (1S,4s)-4-(2-fluoro-5-(((1R,2S)-2-(((1- (fluoromethyl)cyclopropyl)methyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1- methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2- (neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-((2,2-dimethylbutyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-((2-ethylbutyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((R)-3-methylbutan-2- yl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-(((S)-3,3-dimethylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)-2- fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-((2,4-dimethylpentan-3-yl)carbamoyl)cyclopentyl)carbamoyl)-2- fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((R)-1-(1- methylcyclopropyl)ethyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1- carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((S)-1-(1- methylcyclopropyl)ethyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1- carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((1- methylcyclohexyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1- carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-(((R)-3,3-dimethylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)-2- fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2S)-2-(isobutylcarbamoyl)cyclopentyl)carbamoyl)-4- methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((1- methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1- carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((1- methylcyclopropyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane- 1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-((2-cyano-2-methylpropyl)carbamoyl)cyclopentyl)carbamoyl)-2- fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-((3,3,3-trifluoro-2,2- dimethylpropyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1- carboxylic acid; (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((cyclopropylmethyl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0848] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((l-cyanocyclopropyl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0849] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((ls,3R)-3- methylcyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0850] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l- hydroxycyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0851] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l-

[0852] (hydroxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0853] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((2-hydroxy-2- methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0854] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((l-fluoro-2-methylpropan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane-

[0855] 1 -carboxylic acid;

[0856] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l- isopropylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0857] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l-

[0858] (methoxymethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0859] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methoxycyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0860] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((3S,5S)-adamantan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0861] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((cycloheptylmethyl)carbamoyl)bicyclo[2.2.1]heptan-

[0862] 2 -yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0863] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- propylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0864] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((2,2,3,3- tetramethylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0865] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((2-(isopropylamino)-2- oxoethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0866] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l- ethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((3,3- dimethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0867] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0868] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((S)-2-fluoro-3- hydroxypropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0869] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((l- methylcyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0870] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- cyano-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0871] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l- fluorocyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0872] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l- cyanocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0873] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l- fluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0874] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l-

[0875] (fluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0876] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((2,2-difluoropropyl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0877] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((2-fluoro-2- methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0878] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0879] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(tert-butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- cyano-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0880] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((l- methylcyclopropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0881] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((4,4-difluoro-l- hydroxycyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0882] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((2,2,3,3,3- pentafluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid; (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l- hydroxycycloheptyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0883] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l-

[0884] (ethoxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0885] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcycloheptyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0886] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l- isobutylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0887] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((4- cyanocyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0888] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((2-phenylpropan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0889] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((l-

[0890] (hydroxymethyl)cyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0891] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((4-fluorotetrahydro-2H-pyran-4- yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0892] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methoxycyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0893] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-([l,l'-bi(cyclopropan)]-l-ylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0894] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((lr,3S)-3-hydroxyadamantan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0895] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((4-(difluoromethyl)pyrimidin-2- yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0896] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(propylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0897] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(hexylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0898] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((R)-2- phenylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane- 1 -carboxylic acid;

[0899] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((S)-3,3-dimethylbutan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid; (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((R)-l- cyclohexylethyl)carbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1- methylcyclohexane- 1 -carboxylic acid;

[0900] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(cyclohexylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0901] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3-isopropoxypropyl)carbamoyl)bicyclo[2.2.1]heptan-

[0902] 2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0903] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3,4-difluorobenzyl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0904] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((((ls,3R)-3- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0905] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((S)-2- phenylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane- 1 -carboxylic acid;

[0906] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(tert- pentylcarbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)-l -methyl cyclohexane- 1- carboxylic acid;

[0907] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((S)-3-methylbutan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0908] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((4,4- dimethylcyclohexyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0909] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((2-methoxy-2- methylpropyl)carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)phenoxy)-l -methylcyclohexane-

[0910] 1 -carboxylic acid;

[0911] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3,3-dimethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0912] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(((S)-2-fluoro-2- phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0913] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3- cyclopropylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0914] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((2-cyclopropylethyl)carbamoyl)bicyclo[2.2.1]heptan-

[0915] 2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0916] (1 S,4s)-4-(2-cyano-4-methoxy-5-(((l S,2R,3 S,4R)-3-(((lS,2S)-2-(2,2,2- trifluoroethyl)cyclohexyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[0917] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3-fluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0918] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((2,5-dimethylbenzyl)carbamoyl)bicyclo[2.2.1]heptan-

[0919] 2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; (1 S,4s)-4-(2-cyano-4-methoxy-5-(((l S,2R,3 S,4R)-3-(((tetrahydro-2H-pyran-4- yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0920] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3-hydroxy-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1- m ethylcyclohexane- 1 -carboxylic acid;

[0921] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((3- methylbenzyl)carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0922] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-(cyclopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l -carboxylic acid;

[0923] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((R)-l- phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0924] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((S)-l- phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0925] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(bicyclo[l.l.l]pentan-l-ylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0926] (ls,4s)-4-(2-fluoro-4-methoxy-5-((2-(neopentylcarbamoyl)phenyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0927] (1 s,4s)-4-(2-fluoro-4-methoxy-5-((2-(((l - methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0928] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((R)-3-ethylpentan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0929] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((S)-3-ethylpentan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0930] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-(((4-fluorotetrahydro-2H-pyran-4- yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0931] (lR,2S,3R,4S)-3-(5-(((ls,4S)-4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2- methoxybenzamido)-N-((4-fluorotetrahydro-2H-pyran-4-yl)methyl)bicyclo[2.2.1]heptane-2- carboxamide;

[0932] (lS,3s)-3-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclobutane-1 -carboxylic acid;

[0933] (lS,3s)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclobutane-1 -carboxylic acid;

[0934] (ls,4s)-4-(2-fluoro-4-methoxy-5-((4-(((l-methylcyclobutyl)methyl)carbamoyl)pyridin-3- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0935] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R)-2-(((l- methylcyclobutyl)methyl)carbamoyl)cyclooctyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid; ( 1 R,4s)-4-(2-fluoro-4-methoxy-5 -((( 1 R,2 S)-2-((( 1 - methylcyclobutyl)methyl)carbamoyl)cyclooctyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0936] (ls,4s)-4-(2-fluoro-4-methoxy-5-((3-methyl-5-(((l- methylcyclobutyl)methyl)carbamoyl)isothiazol-4-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[0937] (ls,4s)-4-(5-((4-chloro-2-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-

[0938] 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0939] (ls,4s)-4-(2-fluoro-4-methoxy-5-((2-(((l-methylcyclobutyl)methyl)carbamoyl)thiophen-3- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0940] (ls,4s)-4-(5-((5-chloro-2-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-

[0941] 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0942] (ls,4s)-4-(2-fluoro-4-methoxy-5-((2-methyl-6-(((l- methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0943] (ls,4s)-4-(5-((5-chloro-2-((cycloheptylmethyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0944] (ls,4s)-4-(5-((5-chloro-2-(((l-phenylcyclopropyl)methyl)carbamoyl)phenyl)carbamoyl)-2- cyano-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0945] (ls,4s)-4-(5-((5-chloro-2-((((ls,3s)-3-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-

[0946] 2-cyano-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0947] (ls,4s)-4-(5-((5-chloro-2-(((l-fluorocyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-

[0948] 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0949] (ls,4s)-4-(5-((2-(bicyclo[l.l.l]pentan-l-ylcarbamoyl)-5-chlorophenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0950] (lS,4s)-4-(5-((5-chloro-2-(((R)-3-fluoro-3-methylbutan-2-yl)carbamoyl)phenyl)carbamoyl)-2- cyano-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0951] (ls,4s)-4-(5-((5-chloro-2-(tert-pentylcarbamoyl)phenyl)carbamoyl)-2-cyano-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0952] (ls,4s)-4-(5-((5-chloro-2-((2-fluoro-2-methylpropyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0953] (ls,4s)-4-(5-((5-chloro-2-((2-cyclopropylpropan-2-yl)carbamoyl)phenyl)carbamoyl)-2-cyano-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0954] (ls,4s)-4-(2-cyano-5-((2-((3-fluorobenzyl)carbamoyl)-5-methylphenyl)carbamoyl)-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0955] (ls,4s)-4-(2-cyano-5-((2-((2-ethylbutyl)carbamoyl)-5-methylphenyl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0956] (ls,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(pentan-3- ylcarbamoyl)phenyl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0957] (ls,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(((lr,4r)-4- methylcyclohexyl)carbamoyl)phenyl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0958] (lS,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(((R)-3-methylbutan-2- yl)carbamoyl)phenyl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid; (ls,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(((ls,3s)-3- methylcyclobutyl)carbamoyl)phenyl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0959] (ls,4s)-4-(2-cyano-5-((2-(((l-fluorocyclobutyl)methyl)carbamoyl)-5-methylphenyl)carbamoyl)-

[0960] 4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[0961] (ls,4s)-4-(5-((2-(bicyclo[l.l.l]pentan-l-ylcarbamoyl)-5-methylphenyl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[0962] (ls,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(((l- methylcyclopropyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[0963] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((4,4,4- trifluorobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[0964] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((2-cyclopropylethyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0965] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(cyclobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0966] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(bicyclo[l.l.l]pentan-l-ylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0967] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((4-fluoro-3-

[0968] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0969] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0970] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((4-(difluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0971] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[0972] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((4-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[0973] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((2,6-difluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0974] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((3-iodophenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0975] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((4-chloro-3-

[0976] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0977] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3,4,5- trifluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[0978] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-methyl-5-

[0979] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane- 1 -carboxylic acid; (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3-(tert-butyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0980] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3-cyclopropylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0981] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3-cyano-5-

[0982] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0983] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((4-methyl-3-

[0984] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane- 1 -carboxylic acid;

[0985] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[0986] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane- 1 -carboxylic acid;

[0987] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-methoxy-5-

[0988] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-

[0989] 1 -carboxylic acid;

[0990] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3-(difluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-

[0991] 2 -yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0992] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((3-isopropylphenyl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0993] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cy clohexane- 1 -carboxylic acid;

[0994] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0995] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((S)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0996] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((R)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan- 2 -yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[0997] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(phenylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[0998] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((R)-2- methylbutyl)carbamoyl)bicy clo[2.2. l]heptan-2-yl)carbamoyl)phenoxy)cy clohexane- 1- carboxylic acid;

[0999] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((S)-2- methylbutyl)carbamoyl)bicy clo[2.2. l]heptan-2-yl)carbamoyl)phenoxy)cy clohexane- 1- carboxylic acid;

[1000] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1001] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-l- m ethylcyclohexane- 1 -carboxylic acid; (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3R,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1002] (lR,4s)-4-(2-fluoro-5-(((lR,2S,3R,4S)-3-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1- m ethylcyclohexane- 1 -carboxylic acid;

[1003] (lS,4s)-4-(4-(difluoromethoxy)-2-fluoro-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1004] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1005] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1006] 2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[1007] 2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((4-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[1008] (ls,4s)-4-(5-((2,4-dimethyl-6-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2- fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1009] (ls,4s)-4-(5-((4,5-dimethyl-2-(((l-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2- fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1010] (ls,4s)-4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclohex-l-en-l- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1011] (ls,4s)-4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopent-l-en-l- yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1012] (ls,4s)-4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)naphthalen-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1013] (ls,4s)-4-(2-fluoro-4-methoxy-5-((4-methyl-2-(((l- methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1014] (ls,4s)-4-(2-fluoro-4-methoxy-5-((3-(((l-methylcyclobutyl)methyl)carbamoyl)pyrazolo[l,5- a]pyrimidin-2-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1015] 3 -(4-m ethoxy-3 -((( 1 R,2R,3 S,4 S)-3 -((3 -

[1016] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)propanoic acid;

[1017] 3-(4-methoxy-3-(((lS,2S,3R,4R)-3-((3-

[1018] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)propanoic acid;

[1019] (lR,2S,3R,4S)-3-(5-((lH-pyrazol-4-yl)methyl)-4-fluoro-2-methoxybenzamido)-N-(3-

[1020] ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1021] 2-(4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1022] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-lH- pyrazol-l-yl)acetic acid; 1 -(2-fluoro-4-methoxy-5 -((( 1 S,2R,3 S,4R)-3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-lH- pyrazole-5-carboxylic acid;

[1023] 1 -(2-fluoro-4-methoxy-5 -((( 1 S,2R,3 S,4R)-3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-lH- pyrazole-3 -carboxylic acid;

[1024] 2-(4-methoxy-3-(((lR,2R,3S,4S)-3-((3-

[1025] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)benzyl)benzoic acid;

[1026] 2-(4-methoxy-3-(((lS,2S,3R,4R)-3-((3-

[1027] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)benzyl)benzoic acid;

[1028] 2'-fluoro-3,4'-dimethoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1029] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1030] 2'-fluoro-3,4'-dimethoxy-5'-(((lS,2S,3R,4R)-3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1031] 2,2'-difluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1032] 2,2'-difluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1033] 5-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1034] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)nicotinic acid;

[1035] 5-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1036] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)nicotinic acid;

[1037] 4-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3S,4S)-3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)- lH-pyrrole-2-carboxylic acid;

[1038] 4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)- lH-pyrrole-2-carboxylic acid;

[1039] 2'-fluoro-4,4'-dimethoxy-5'-(((lR,2R,3S,4S)-3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[1040] 2'-fluoro-4,4'-dimethoxy-5'-(((lS,2S,3R,4R)-3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[1041] 2',4-difluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid; 2',4-difluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1042] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[1043] 2',3-difluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1044] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1045] 2',3-difluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1046] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1047] 2,2'-difluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1048] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[1049] 2,2'-difluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1050] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[1051] 2-(2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1052] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)acetic acid;

[1053] 2-(2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1054] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)acetic acid;

[1055] 2-(2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1056] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-2-yl)acetic acid;

[1057] 2-(2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1058] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-2-yl)acetic acid;

[1059] 2',3-difluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1060] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1061] 3 -(5-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1062] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrimidin-2-yl)propanoic acid;

[1063] 3 -(5-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1064] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrazin-2-yl)propanoic acid;

[1065] 3-(dimethylamino)-2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1066] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1067] 4-((2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1068] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)oxy)butanoic acid;

[1069] 2'-fluoro-4'-methoxy-3,5-dimethyl-5'-(((lS,2R,3S,4R)-3-((3-

[1070] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid; 2-((S)-6-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1071] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2,3- dihydrobenzofuran-3 -yl)acetic acid;

[1072] 2-((R)-6-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1073] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2,3- dihydrobenzofuran-3 -yl)acetic acid;

[1074] (5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1075] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrimidin-2-yl)glycine;

[1076] 2-((5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1077] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridin-2-yl)oxy)acetic acid;

[1078] 3 -(6-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1079] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbam oyl)phenyl)pyri din-3 -yl)propanoic acid;

[1080] 2-((2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1081] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)oxy)-2-methylpropanoic acid;

[1082] 2-((2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1083] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)oxy)acetic acid;

[1084] 3 -(2-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1085] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)thiazol-5-yl)propanoic acid;

[1086] 3-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1087] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1088] 3 -(6-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1089] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridazin-3-yl)propanoic acid;

[1090] 2'-fluoro-4'-methoxy-3-methyl-5'-(((lS,2R,3S,4R)-3-((3-

[1091] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1092] 2'-fluoro-3-hydroxy-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1093] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1094] 3 -(5-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1095] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridin-2-yl)propanoic acid;

[1096] 3-(2'-fluoro-3,4'-dimethoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1097] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1098] (E)-3-(5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1099] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridin-2-yl)acrylic acid; (lR,2R)-2-(5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1100] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbam oyl)phenyl)pyridin-2-yl)cy cl opropane-1 -carboxylic acid;

[1101] (lS,2S)-2-(5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1102] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyridin-2-yl)cy cl opropane-1 -carboxylic acid;

[1103] (lR,2R)-2-(5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1104] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrazin-2-yl)cyclopropane- 1 -carboxylic acid;

[1105] (lS,2S)-2-(5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1106] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrazin-2-yl)cyclopropane- 1 -carboxylic acid;

[1107] (lR,2S,3R,4S)-3-(6-fluoro-4-methoxy-4'-sulfamoyl-[l,r-biphenyl]-3-carboxamido)-N-(3- ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1108] (lR,2S,3R,4S)-3-(4'-(2-amino-l,3-dihydroxypropan-2-yl)-6-fluoro-4-methoxy-[l,r-biphenyl]-

[1109] 3-carboxamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1110] (lR,2S,3R,4S)-3-(4'-(3-amino-4-hydroxy-3-(hydroxymethyl)butyl)-3',6-difluoro-4-methoxy- [l,r-biphenyl]-3-carboxamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane- 2-carboxamide;

[1111] 3 -(4-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1112] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2- oxopyridin- 1 (2H)-yl)propanoic acid;

[1113] 2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1114] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1115] 3 -(4-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1116] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-lH- pyrazol-l-yl)propanoic acid;

[1117] (R)-2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1118] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2,3,4,5- tetrahydro-[l, l'-biphenyl]-4-carboxylic acid;

[1119] (S)-2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1120] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2,3,4,5- tetrahydro-[l, l'-biphenyl]-4-carboxylic acid;

[1121] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1122] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)cyclohexane- 1 -carboxylic acid;

[1123] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1124] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)cyclohexane- 1 -carboxylic acid;

[1125] 6-fluoro-4-methoxy-N3-((lR,2R,3S,4S)-3-((3-

[1126] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)-[l,r-biphenyl]-3,4'- dicarboxamide;

[1127] 2-(4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1128] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)- lH-pyrazol-l-yl)acetic acid; 4-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1129] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid;

[1130] 4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1131] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid;

[1132] 2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1133] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,l'- biphenyl]-2-carboxylic acid;

[1134] 2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1135] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-2-carboxylic acid;

[1136] 5-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1137] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid;

[1138] 5-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1139] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid;

[1140] 2-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1141] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)oxazole-4-carboxylic acid;

[1142] 2-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1143] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)oxazole-4-carboxylic acid;

[1144] 5-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1145] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)pyrazine-2-carboxylic acid;

[1146] 5-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1147] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)pyrazine-2-carboxylic acid;

[1148] 2-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1149] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)isonicotinic acid;

[1150] 2-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1151] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)isonicotinic acid;

[1152] 6-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1153] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)nicotinic acid;

[1154] 6-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1155] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)nicotinic acid;

[1156] 6-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1157] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid; 6-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1158] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)picolinic acid;

[1159] 5-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1160] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)pyrimidine-2-carboxylic acid;

[1161] 5-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1162] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)pyrimidine-2-carboxylic acid;

[1163] 2-(2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1164] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)acetic acid;

[1165] 2-(2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1166] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)acetic acid;

[1167] 3-(2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1168] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)propanoic acid;

[1169] 3-(2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1170] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)propanoic acid;

[1171] 3-(2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1172] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1173] 3-(2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1174] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1175] 5-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1176] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiophene-3 -carboxylic acid;

[1177] 5-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1178] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiophene-3 -carboxylic acid;

[1179] 5-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1180] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiophene-2-carboxylic acid;

[1181] 5-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1182] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiophene-2-carboxylic acid;

[1183] 2-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1184] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiazole-4-carboxylic acid;

[1185] 2-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1186] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiazole-4-carboxylic acid; 2-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1187] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiazole-5-carboxylic acid;

[1188] 2-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1189] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenyl)thiazole-5-carboxylic acid; l-(2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1190] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)cyclopropane- 1 -carboxylic acid; l-(2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1191] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)cyclopropane- 1 -carboxylic acid;

[1192] (S)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((lR,2S,3R,4S)-3-((3-

[1193] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1194] (S)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1195] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1196] (R)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((lR,2S,3R,4S)-3-((3-

[1197] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1198] (R)-2-amino-3-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1199] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1200] (R)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1201] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)propanoic acid;

[1202] (R)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1203] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)propanoic acid;

[1204] (S)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1205] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)propanoic acid;

[1206] (R)-2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1207] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)acetic acid;

[1208] (S)-2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1209] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3-yl)acetic acid;

[1210] (R)-2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1211] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)acetic acid;

[1212] (S)-2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1213] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)acetic acid; 2'-fluoro-5'-(((lR,2R,3S,4S)-3-((4-fluoro-3-

[1214] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'- methoxy-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[1215] 2'-fluoro-5'-(((lS,2S,3R,4R)-3-((4-fluoro-3-

[1216] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'- methoxy-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[1217] 2'-fluoro-5'-(((lR,2R,3S,4S)-3-((4-fluoro-3-

[1218] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'- methoxy-[ 1 , 1 '-biphenyl]-3 -carboxylic acid;

[1219] 2'-fluoro-5'-(((lS,2S,3R,4R)-3-((4-fluoro-3-

[1220] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'- methoxy-[ 1 , 1 '-biphenyl]-3 -carboxylic acid;

[1221] 2'-fluoro-5'-(((lR,2R,3S,4S)-3-((3-fluoro-5-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[l,r- biphenyl]-4-carboxylic acid;

[1222] 2'-fluoro-5'-(((lS,2S,3R,4R)-3-((3-fluoro-5-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[l,r- biphenyl]-4-carboxylic acid;

[1223] 2'-fluoro-4'-methoxy-5'-(((lR,2S)-2-((3-

[1224] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-4- carboxylic acid;

[1225] 2'-fluoro-4'-methoxy-5'-(((lS,2R)-2-((3-

[1226] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-4- carboxylic acid;

[1227] 2'-fluoro-4'-methoxy-5'-(((lR,2S)-2-((3-

[1228] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-3- carboxylic acid;

[1229] 2'-fluoro-4'-methoxy-5'-(((lS,2R)-2-((3-

[1230] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-3- carboxylic acid;

[1231] 2'-fluoro-4'-methoxy-5'-(((lR,2S)-2-((3-

[1232] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[l,r-biphenyl]-4- carboxylic acid;

[1233] 2'-fluoro-4'-methoxy-5'-(((lS,2R)-2-((3-

[1234] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[l,r-biphenyl]-4- carboxylic acid;

[1235] 2'-fluoro-4'-methoxy-5'-(((lR,2S)-2-((3-

[1236] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[l,r-biphenyl]-3- carboxylic acid;

[1237] 2'-fluoro-4'-methoxy-5'-(((lS,2R)-2-((3-

[1238] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[l,r-biphenyl]-3- carboxylic acid;

[1239] 2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1240] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid; 2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1241] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1242] 2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[1243] 2'-fluoro-5'-(((lR,2R,3S,4S)-3-((3-

[1244] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1245] 2'-fluoro-5'-(((lS,2S,3R,4R)-3-((3-

[1246] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1247] 2',4'-difluoro-5'-(((lR,2R,3S,4S)-3-((3-

[1248] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1249] 2',4'-difluoro-5'-(((lS,2S,3R,4R)-3-((3-

[1250] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1251] 2'-fluoro-5'-(((lR,2R,3S,4S)-3-((4-fluoro-3-

[1252] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[l,r- biphenyl]-4-carboxylic acid;

[1253] 2'-fluoro-5'-(((lS,2S,3R,4R)-3-((4-fluoro-3-

[1254] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[l,r- biphenyl]-4-carboxylic acid;

[1255] 2'-fluoro-5'-(((lR,2R,3S,4S)-3-((3-fluoro-5-

[1256] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[l,r- biphenyl]-4-carboxylic acid;

[1257] 2'-fluoro-5'-(((lS,2S,3R,4R)-3-((3-fluoro-5-

[1258] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[l,r- biphenyl]-4-carboxylic acid;

[1259] 5'-(((lR,2R,3S,4S)-3-((3-cyano-4-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-2'-fluoro-4'-methoxy-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[1260] 5'-(((lS,2S,3R,4R)-3-((3-cyano-4-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-2'-fluoro-4'-methoxy-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[1261] 5'-(((lR,2R,3S,4S)-3-((3-cyano-5-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-2'-fluoro-4'-methoxy-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[1262] 5'-(((lS,2S,3R,4R)-3-((3-cyano-5-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)-2'-fluoro-4'-methoxy-[ 1 , 1 '-biphenyl]-4-carboxylic acid;

[1263] 2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-(((S)-l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[1264] 2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-(((S)-l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[1265] 2'-fluoro-4'-methoxy-5'-(((lR,2S,3R,4S)-3-(((S)-l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[1266] 2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-(((S)-l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid; 2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-(((R)-l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[1267] 2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-(((R)-l-((trifluoromethyl)sulfonyl)piperidin-3- yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,l'-biphenyl]-4-carboxylic acid;

[1268] 2-(2'-fluoro-4'-methoxy-5'-(((lR,2S)-2-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-3- yl)acetic acid;

[1269] 3-(2'-fluoro-4'-methoxy-5'-(((lR,2S)-2-((3-

[1270] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-3- yl)propanoic acid;

[1271] 2-(2'-fluoro-4'-methoxy-5'-(((lR,2S)-2-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-4- yl)acetic acid;

[1272] 3-(2'-fluoro-4'-methoxy-5'-(((lR,2S)-2-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[l,r-biphenyl]-4- yl)propanoic acid;

[1273] 3 -(5-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 - ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)- l,3,4-thiadiazol-2-yl)propanoic acid;

[1274] 3 -(2-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -((3 -

[1275] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrimidin-5-yl)propanoic acid;

[1276] 3 -(5 -(2-fluoro-4-m ethoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1277] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrazin-2-yl)propanoic acid;

[1278] 3-(5-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1279] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenyl)pyrazin-2-yl)propanoic acid;

[1280] (lR,2S,3R,4S)-3-(6-fluoro-4-methoxy-4'-(lH-tetrazol-5-yl)-[l,r-biphenyl]-3-carboxamido)-N- (3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1281] (lR,2R,3S,4S)-3-(6-fluoro-4-methoxy-4'-(2-sulfamoylethyl)-[l,l'-biphenyl]-3-carboxamido)-N- (3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1282] (lS,2S,3R,4R)-3-(6-fluoro-4-methoxy-4'-(2-sulfamoylethyl)-[l,l'-biphenyl]-3-carboxamido)-N- (3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1283] 2'-fluoro-4'-methoxy-5'-((2-((3- ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)phenyl)carbamoyl)-[l,r-biphenyl]-4-carboxylic acid;

[1284] 2-((2'-cyano-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1285] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-4-yl)oxy)acetic acid;

[1286] 2-((2'-fluoro-4'-methoxy-5'-(((lS,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-[ 1 , 1 '-biphenyl]-4-yl)oxy)acetic acid;

[1287] ( 1 R,4s)-4-(5 -((( 1 R,2R,3 S,4 S)-7-(tert-butoxy carbonyl)-3 -((( 1 - methylcyclobutyl)methyl)carbamoyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; (lR,4s)-4-(5-(((lS,2S,3R,4R)-7-(tert-butoxycarbonyl)-3-(((l- methylcyclobutyl)methyl)carbamoyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1288] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2S)-2-((3-

[1289] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1290] (lS,4s)-4-(2-fluoro-5-(((lR,2S)-2-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1291] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1- m ethylcyclohexane- 1 -carboxylic acid;

[1292] (lS,4s)-4-(2-fluoro-5-(((lR,2R)-2-fluoro-2-((3-

[1293] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1294] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((2S,3R)-2-((3-

[1295] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1296] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((2S,3R)-2-((3-

[1297] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1298] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2S,3R,4S)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-oxabicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1299] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-oxabicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1300] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lR,2S)-2-(((l- methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1301] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lR,2S)-2-(((l- methylcyclobutyl)methyl)carbamoyl)cyclohexyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1302] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- (hydroxymethyl)cyclohexane- 1 -carboxylic acid;

[1303] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l-

[1304] (trifluoromethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-

[1305] 1-(hydroxymethyl)cyclohexane-l -carboxylic acid;

[1306] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1307] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-

[1308] 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1309] (lS,4s)-4-(4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- (trifluoromethyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid; (lS,4s)-4-(2-(difluoromethyl)-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1310] (lS,4s)-4-(3-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1311] (lS,4s)-4-(4-methoxy-2-methyl-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1312] (lS,4s)-4-(2-ethyl-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1313] (lS,4s)-4-(4-cyano-2-fluoro-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1314] (lS,4s)-l-methyl-4-((l-methyl-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-lH-indazol-7- yl)oxy)cyclohexane- 1 -carboxylic acid;

[1315] (lS,4s)-l-methyl-4-((l-methyl-6-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-lH-indazol-4- yl)oxy)cyclohexane- 1 -carboxylic acid;

[1316] (lS,4s)-4-(2-fluoro-4-(methoxymethyl)-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1317] (lS,4s)-4-(4-methoxy-3-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1318] (1 S,4s)-4-(5-(((l S,2R,3 S,4R)-3 -((3 -fluorobicyclofl .1 ,l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxy-2-methylphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1319] (1 S,4s)-4-(2-ethyl-5-(((l S,2R,3 S,4R)-3 -((3 -fluorobicyclofl .1. l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1320] (1 S,4s)-4-(4-ethoxy-2-fluoro-5-(((l S,2R, 3 S,4R)-3 -((3 -fluorobicyclofl .1. l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1321] (lS,4s)-4-(4-ethoxy-2-fluoro-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1322] (lS,4s)-l-ethyl-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-

[1323] (neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1324] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lR,2S,3R,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid; (lR,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1325] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lR,2R,3S,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1326] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lR,2R,3S,4S)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1327] (1 S,4s)-4-(3-fluoro-5-(((l S,2R, 3 S,4R)-3 -((3 -fluorobicyclofl .1. l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1328] (lS,4s)-4-(2-fluoro-4-(2-methoxyethoxy)-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1329] (lS,4s)-4-(2-chloro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1330] (lS,4s)-4-(2,4-difluoro-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1331] ( 1 R,4s)-4-(2-fluoro-5 -((( 1 S,2R, 5 S)-2-hy droxy-5 -((3 -

[1332] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1333] ( 1 R,4s)-4-(2-fluoro-5 -((( 1 R,2 S, 5R)-2-hy droxy-5 -((3 -

[1334] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1335] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,5S)-2-methoxy-5-((3-

[1336] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1337] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2S,5R)-2-methoxy-5-((3-

[1338] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1339] (lS,4s)-4-(4-chloro-2-fluoro-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1340] (lS,4s)-4-(2-cyclopropyl-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1341] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1342] (lS,4s)-4-(2-cyano-4-fluoro-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid; (lS,4s)-4-(4-methoxy-2-(methoxymethyl)-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1343] (lS,4s)-4-(3-chloro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1344] (lS,4s)-4-(3-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1345] (lS,4s)-4-(4-methoxy-3-methyl-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1346] (lS,4s)-l-methyl-4-((7-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2,3- dihydrobenzofuran-5-yl)oxy)cyclohexane-l -carboxylic acid;

[1347] (lS,4s)-l-methyl-4-((8-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)quinolin-6- yl)oxy)cyclohexane- 1 -carboxylic acid;

[1348] (lS,4s)-4-(2-chloro-4-fluoro-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1349] (lS,4s)-4-(2-chloro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3,3,3-trifluoro-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1350] (lS,4s)-4-(2-chloro-4-methoxy-5-(((lR,2R,3S,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1351] (1 S,4s)-4-(2-chloro-5-(((l S,2R,3 S,4R)-3 -((3 -fluorobicyclofl .1. l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane-

[1352] 1 -carboxylic acid;

[1353] (lS,4s)-4-(2-chloro-4-methoxy-5-(((lS,2R,3S,4R)-3-

[1354] (neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1355] (lS,4s)-4-(2-cyano-4-fluoro-5-(((lR,2R,3S,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1356] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lS,2S,3R,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-

[1357] 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1358] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lR,2R,3S,4S)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1359] ( 1 R,4r)- 1 -fluoro-4-(2-fluoro-4-methoxy-5 -((( 1 S,2R, 3 S,4R)-3 -((( 1 - methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1360] ( 1 R,4r)- 1 -fluoro-4-(2-fluoro-4-methoxy-5 -((( 1 S,2R, 3 S,4R)-3 -((3 -

[1361] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid; (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1362] (lR,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((ls,4S)-4-methyl-4-(5-oxo-4,5-dihydro-l,2,4- oxadiazol-3-yl)cyclohexyl)oxy)benzamido)-N-((l- methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1363] (lR,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((ls,4S)-4-methyl-4-(5-oxo-4,5-dihydro-l,3,4- oxadiazol-2-yl)cyclohexyl)oxy)benzamido)-N-((l- methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1364] (lR,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((ls,4S)-4-methyl-4-(lH-tetrazol-5- yl)cyclohexyl)oxy)benzamido)-N-((l-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2- carboxamide;

[1365] (lS,2S,3R,4R)-3-(5-(((ls,4S)-4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2- methoxybenzamido)-N-((l-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1366] (lR,4r)-l-(cyanomethyl)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1367] (lS,4s)-l-(cyanomethyl)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1368] (lR,3s,5S,6S)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)bicyclo[3.1 ,0]hexane-6-carboxylic acid;

[1369] (lR,3r,5S,6R)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)bicyclo[3.1 ,0]hexane-6-carboxylic acid;

[1370] (lR,3r,5S,6S)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)bicyclo[3.1 ,0]hexane-6-carboxylic acid;

[1371] (lR,3s,5S,6R)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1 ]heptan-2- yl)carbamoyl)phenoxy)bicyclo[3.1 ,0]hexane-6-carboxylic acid;

[1372] 4-(4-methoxy-3-(((lR,2R,3S,4S)-3-((3-

[1373] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[1374] 4-(4-methoxy-3-(((lS,2S,3R,4R)-3-((3-

[1375] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[1376] 3 -(4-m ethoxy-3 -((( 1 R,2R,3 S,4 S)-3 -((3 -

[1377] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[1378] 3-(4-methoxy-3-(((lS,2S,3R,4R)-3-((3-

[1379] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid; 2-(4-methoxy-3-(((lR,2R,3S,4S)-3-((3-

[1380] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[1381] 2-(4-methoxy-3-(((lS,2S,3R,4R)-3-((3-

[1382] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[1383] (lS,4s)-4-(2,4-difluoro-5-(((lS,2R,3S,4R)-3-((3-

[1384] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1385] 5-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-2,2- dimethylpentanoic acid;

[1386] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1387] (lS,2S,3R,4R)-3-(5-(((ls,4S)-4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-

[1388] (3-(pentafluoro-X6-sulfaneyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1389] 6-fluoro-4-methoxy-N3-((lS,2R,3S,4R)-3-((3-

[1390] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)-[l,r-biphenyl]-3,4'- dicarboxamide;

[1391] 6-(2-fluoro-4-methoxy-5 -((( 1 S,2R,3 S,4R)-3 -((3 -

[1392] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)hexanoic acid;

[1393] 7-(2-fluoro-4-methoxy-5 -((( 1 S,2R,3 S,4R)-3 -((3 -

[1394] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)heptanoic acid;

[1395] 9-(2-fluoro-4-methoxy-5 -((( 1 S,2R,3 S,4R)-3 -((3 -

[1396] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)nonanoic acid;

[1397] 4-((2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1398] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[1399] (lR,4r)-4-((2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1400] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)cyclohexane-l -carboxylic acid;

[1401] (lS,4s)-4-((2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1402] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)cyclohexane-l -carboxylic acid;

[1403] 4-((2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1404] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)bicyclo[2.2.2]octane-l -carboxylic acid;

[1405] (2R,5R)-5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1406] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid; (2S,5S)-5-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1407] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid;

[1408] (lR,3r)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1409] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclobutane- 1 -carboxylic acid;

[1410] (lS,3s)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1411] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclobutane- 1 -carboxylic acid;

[1412] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1413] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1414] (lR,3R)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1415] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1416] (lR,3S)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1417] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1418] (lS,3S)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1419] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1420] (lS,3R)-3-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1421] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1422] 2-((2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1423] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[1424] 2-((2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1425] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[1426] 3-((2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1427] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[1428] 3-((2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1429] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[1430] 4-((2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1431] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[1432] 4-((2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1433] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)benzoic acid;

[1434] 5-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1435] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)pentanoic acid; 5-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1436] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)pentanoic acid;

[1437] 2-(4-((2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1438] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid;

[1439] 2-(4-((2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1440] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid;

[1441] 2-(3-((2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1442] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)acetic acid;

[1443] 2-(3-((2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1444] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)acetic acid;

[1445] 2-(3-((2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1446] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid;

[1447] 2-(3-((2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1448] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid;

[1449] 6-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1450] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)hexanoic acid;

[1451] 6-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1452] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)hexanoic acid;

[1453] 4-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1454] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)butanoic acid;

[1455] 4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1456] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)butanoic acid;

[1457] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1458] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1459] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1460] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1461] (lR,4r)-l-amino-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1462] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1463] (lS,4s)-l-amino-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1464] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid; (lR,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((ls,4S)-4-

[1465] (methylsulfonamido)cyclohexyl)oxy)benzamido)-N-(3-

[1466] ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1467] (lR,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((lr,4R)-4-

[1468] (methylsulfonamido)cyclohexyl)oxy)benzamido)-N-(3-

[1469] ((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1470] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((3aS,4S,5R,6S,7R,7aR)-6-((3-

[1471] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)hexahydro-4,7-methanobenzo[d][l,3]dioxol-5- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1472] (lS,2S,3R,4R)-3-(4-fluoro-2-methoxy-5-(((lr,4R)-4-sulfamoylcyclohexyl)oxy)benzamido)-N-

[1473] (3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1474] (lS,2S,3R,4R)-3-(4-fluoro-2-methoxy-5-(((ls,4S)-4-sulfamoylcyclohexyl)oxy)benzamido)-N-

[1475] (3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1476] (lS,4s)-4-(2-bromo-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1477] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1478] (lS,4s)-4-(4-methoxy-2-methyl-5-(((lS,2R,3S,4R)-3-((3-

[1479] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1480] (lS,4s)-4-(4-methoxy-3-(((lS,2R,3S,4R)-3-((3-

[1481] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1482] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1483] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1484] (lR,3r)-3-((2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1485] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)cyclobutane-l -carboxylic acid;

[1486] (lS,3s)-3-((2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1487] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)methyl)cyclobutane-l -carboxylic acid;

[1488] 2-((lR,3r)-3-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1489] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclobutyl)acetic acid;

[1490] 2-((lS,3s)-3-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1491] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclobutyl)acetic acid;

[1492] 2-((lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexyl)acetic acid;

[1493] 2-((lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexyl)acetic acid;

[1494] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-

[1495] (trifluoromethyl)cyclohexane- 1 -carboxylic acid; (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1496] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- (methoxymethyl)cyclohexane- 1 -carboxylic acid;

[1497] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1498] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- (methoxymethyl)cyclohexane- 1 -carboxylic acid;

[1499] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)phenoxy)- 1 -(methoxymethyl)cyclohexane- 1 -carboxylic acid;

[1500] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1501] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- (methoxymethyl)cyclohexane- 1 -carboxylic acid;

[1502] 4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)benzoic acid;

[1503] 4-(2-fluoro-4-methoxy-5 -((( 1 R,2R, 3 S,4 S)-3 -((3 -

[1504] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[1505] 4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1506] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)benzoic acid;

[1507] (lR,4r)-4-(2-fluoro-4-isopropoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-

[1508] (m ethoxy carbonyl)cyclohexane- 1 -carboxylic acid;

[1509] (lS,4s)-4-(2-fluoro-4-isopropoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- (hydroxymethyl)cyclohexane- 1 -carboxylic acid;

[1510] (lS,4s)-4-(2-fluoro-5-(((lR,2R,3S,4S)-3-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1511] (lS,4s)-4-(2-fluoro-5-(((lR,2R,3S,4S)-3-((4-fluoro-3-

[1512] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1513] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2S)-2-((3-

[1514] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[1515] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3-

[1516] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1517] (lS,4s)-4-(2-fluoro-5-(((lR,2S)-2-((4-fluoro-3-

[1518] (trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)cyclohexane-l- carboxylic acid;

[1519] (lR,4s)-4-(5-(((lS,2R)-4,4-difluoro-2-((4-fluoro-3-

[1520] (trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid; (lR,4s)-4-(5-(((lR,2S)-4,4-difluoro-2-((4-fluoro-3-

[1521] (trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1522] (lS,4s)-4-(5-(((lS,2R,3S,4R,5R,6S)-5,6-dihydroxy-3-((3-

[1523] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1524] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1525] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1526] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1527] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1528] ( 1 R,4s)-4-(2-fluoro-5 -((( 1 S,2R,4 S)-4-hy droxy-2-((3 -

[1529] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1530] ( 1 R,4s)-4-(2-fluoro-5 -((( 1 R,2 S,4R)-4-hy droxy-2-((3 -

[1531] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1532] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((4-methoxy-3-

[1533] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2- yl)carbamoyl)phenoxy)cyclohexane-l -carboxylic acid;

[1534] (lS,4s)-4-(2-fluoro-5-(((lR,2R,3S,4S)-3-((4-fluoro-3-

[1535] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1536] (lS,2S,3R,4R)-3-(5-(((ls,4S)-4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-

[1537] (4-fluoro-3-(trifluoromethyl)phenyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide;

[1538] (lR,2S,3R,4S)-3-(5-(((ls,4S)-4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-

[1539] (4-fluoro-3-(trifluoromethyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide;

[1540] (lR,4s)-4-(2-fluoro-5-(((lS,2S,3R,4R)-3-((4-fluoro-3-

[1541] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4- methoxyphenoxy)cyclohexane-l -carboxylic acid;

[1542] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lR,2R,3S,4S)-3-((3,3,3-trifluoro-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1543] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((R)-2,2-dimethylcyclopentyl)carbamoyl)bicyclo[2.2.1]heptan-

[1544] 2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1545] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((S)-2,2-dimethylcyclopentyl)carbamoyl)bicyclo[2.2.1]heptan-

[1546] 2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1547] (lS,3s)-3-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1548] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclobutane-1 -carboxylic acid;

[1549] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethoxy cyclohexane- 1 -carboxylic acid; (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- hydroxycyclohexane-1 -carboxylic acid;

[1550] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1551] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methoxy cyclohexane- 1 -carboxylic acid;

[1552] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[1553] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-l- carboxylic acid;

[1554] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3aR,4S,5S,6aS)-5-((3-

[1555] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-4H-cyclopenta[d][l,3]dioxol-4- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1556] ( 1 R,4s)-4-(2-fluoro-4-methoxy-5 -(((3 aS,4R, 5R, 6aR)-5 -((3 -

[1557] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-4H-cyclopenta[d][l,3]dioxol-4- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1558] (lR,4s)-4-(5-(((3R,4S)-l-acetyl-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)piperidin-4- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1559] (lR,4s)-4-(5-(((3S,4R)-l-acetyl-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)piperidin-4- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1560] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R)-2-((3-

[1561] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cycloheptyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1562] ( 1 R,4s)-4-(2-fluoro-4-methoxy-5 -((( 1 R,2 S)-2-((3 -

[1563] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cycloheptyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1564] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4S)-3-((3-

[1565] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-4-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1566] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4R)-3-((3-

[1567] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-4-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1568] (lR,4s)-4-(2-fluoro-5-(((lS,2S,3R,4R)-3-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1- m ethylcyclohexane- 1 -carboxylic acid;

[1569] ( 1 R,4s)-4-(2-fluoro-5 -((( 1 R,2R, 3 S,4 S)-3 -((4-fluoro-3 -(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1- m ethylcyclohexane- 1 -carboxylic acid;

[1570] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,4S)-4-methoxy-2-((3-

[1571] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1572] ( 1 R,4s)-4-(2-fluoro-4-methoxy-5 -((( 1 R,2 S,4R)-4-methoxy-2-((3 -

[1573] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid; (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,4R)-4-methoxy-2-((3-

[1574] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1575] ( 1 R,4s)-4-(2-fluoro-4-methoxy-5 -((( 1 R,2 S,4 S)-4-methoxy-2-((3 -

[1576] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1577] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2S,5S)-2-methoxy-5-((3-

[1578] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1579] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,5R)-2-methoxy-5-((3-

[1580] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1581] (lR,4s)-4-(2-fluoro-5-(((lS,2S,5S)-2-hydroxy-5-((3-

[1582] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1583] (lR,4s)-4-(2-fluoro-5-(((lR,2R,5R)-2-hydroxy-5-((3-

[1584] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1585] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-oxabicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1586] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-oxabicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1587] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-oxabicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)- 1 -(hydroxymethyl)cy clohexane- 1 - carboxylic acid;

[1588] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-oxabicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)- 1 -(hydroxymethyl)cy clohexane- 1 - carboxylic acid;

[1589] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lS,2S,3R,4R)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-oxabicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1590] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lR,2R,3S,4S)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-oxabicyclo[2.2.1 ]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1591] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lS,2S,3R,4R)-3-(((l-methylcyclobutyl)methyl)carbamoyl)- 7-(3,3,3-trifluoropropyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1592] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lR,2R,3S,4S)-3-(((l-methylcyclobutyl)methyl)carbamoyl)-

[1593] 7-(3,3,3-trifluoropropyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1594] (lR,4s)-4-(2-cyano-4-methoxy-5-(((2S,3R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1595] (lR,4s)-4-(2-cyano-4-methoxy-5-(((2R,3S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid; (lR,4s)-4-(2-cyano-4-methoxy-5-(((lR,2S,3R,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1596] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1597] ( 1 R,4s)-4-(2-fluoro-4-methoxy-5 -(((2 S, 3R)-3 -((( 1 - methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1598] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((2R,3S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1599] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2S,3R,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1600] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-l- m ethyl cyclohexane- 1 -carboxylic acid;

[1601] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,4R)-4-methoxy-2-

[1602] (neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-methylcyclohexane-l-carboxylic acid;

[1603] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2S,4S)-4-methoxy-2-

[1604] (neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-methylcyclohexane-l-carboxylic acid;

[1605] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,4R)-4-methoxy-2-

[1606] (neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-(hydroxymethyl)cyclohexane-l- carboxylic acid;

[1607] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2S,4S)-4-methoxy-2-

[1608] (neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-l-(hydroxymethyl)cyclohexane-l- carboxylic acid;

[1609] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,4R)-4-methoxy-2-(((l- methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- (hydroxymethyl)cyclohexane- 1 -carboxylic acid;

[1610] ( 1 R,4s)-4-(2-fluoro-4-methoxy-5 -((( 1 R,2 S,4 S)-4-methoxy-2-((( 1 - methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-l- (hydroxymethyl)cyclohexane- 1 -carboxylic acid;

[1611] 2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1612] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1613] 2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1614] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-4-carboxylic acid;

[1615] 2'-fluoro-4'-methoxy-5'-(((lR,2R,3S,4S)-3-((3-

[1616] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid; 2'-fluoro-4'-methoxy-5'-(((lS,2S,3R,4R)-3-((3-

[1617] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[1618] 2'-fluoro-4-hydroxy-4'-methoxy-5'-(((lR,2S,3R,4S)-3-((3-

[1619] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[1620] 2'-fluoro-4-hydroxy-4'-methoxy-5'-(((lS,2R,3S,4R)-3-((3-

[1621] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[l,r- biphenyl]-3 -carboxylic acid;

[1622] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4S)-4-((3-

[1623] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1624] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4R)-4-((3-

[1625] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1626] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-((3-

[1627] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1628] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-((3-

[1629] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1630] (lR,4s)-4-(5-(((lS,2R,3S,5S)-2,3-dihydroxy-5-((3-

[1631] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1632] (lR,4s)-4-(5-(((lR,2S,3R,5R)-2,3-dihydroxy-5-((3-

[1633] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4- methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1634] (lR,4s)-4-(2-fluoro-5-(((3S,4R)-4-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1635] (lR,4s)-4-(2-fluoro-5-(((3R,4S)-4-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1636] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-(neopentylcarbamoyl)tetrahydrofuran-3- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1637] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-(neopentylcarbamoyl)tetrahydrofuran-3- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1638] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R)-2-

[1639] (neopentylcarbamoyl)cy clobutyl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1640] ( 1 R,4s)-4-(2-fluoro-4-methoxy-5 -((( 1 R,2 S)-2-

[1641] (neopentylcarbamoyl)cy clobutyl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1642] (lR,4s)-4-(2-fluoro-5-(((lS,2R)-2-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane- 1 -carboxylic acid; ( 1 R,4s)-4-(2-fluoro-5 -((( 1 R,2 S)-2-((4-fluoro-3 -(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane- 1 -carboxylic acid;

[1643] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R)-2-(((l- methylcyclobutyl)methyl)carbamoyl)cyclobutyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1644] (lR,4s)-4-(2-cyano-4-methoxy-5-(((lR,2S)-2-(((l- methylcyclobutyl)methyl)carbamoyl)cyclobutyl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1645] ( 1 R,4s)-4-(2-fluoro-5 -(((3 S,4 S)-4-((4-fluoro-3 -(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1646] (lR,4s)-4-(2-fluoro-5-(((3R,4R)-4-((4-fluoro-3-(pentafluoro-X6- sulfaneyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1647] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-(((l- methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1648] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-(((l- methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1649] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-(neopentylcarbamoyl)tetrahydrofuran-3- yl)carbamoyl)phenoxy)- 1 -(hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[1650] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-(neopentylcarbamoyl)tetrahydrofuran-3- yl)carbamoyl)phenoxy)- 1 -(hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[1651] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-(((l- methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l-

[1652] (hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[1653] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-(((l- methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-l-

[1654] (hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[1655] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1656] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- hydroxycyclohexane-1 -carboxylic acid;

[1657] (lR,4r)-4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1658] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- hydroxycyclohexane-1 -carboxylic acid;

[1659] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1660] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-

[1661] (hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[1662] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1663] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-

[1664] (hydroxymethyl)cy clohexane- 1 -carboxylic acid;

[1665] (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2S,3R,4R)-3-((3-

[1666] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid; (lR,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)-3-((3-

[1667] ((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1668] (lR,4s)-4-(2-cyano-4-fluoro-5-(((2S,3R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1669] ( 1 R,4s)-4-(2-cy ano-4-fluoro-5 -(((2R, 3 S)-3 -((( 1 - methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1670] 2'-fluoro-5'-(((lR,2S,3R,4S)-3-((4-fluoro-3-

[1671] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4'-methoxy-[l,r- biphenyl]-4-carboxylic acid;

[1672] 2'-fluoro-5'-(((lS,2R,3S,4R)-3-((4-fluoro-3-

[1673] (trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4'-methoxy-[l,r- biphenyl]-4-carboxylic acid;

[1674] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1675] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methoxycyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1676] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l-

[1677] (methoxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1678] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((l-cyanocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1679] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((3,3,3- trifluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1680] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((R)-l,l,l-trifluoropropan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1681] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(cyclobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1682] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(cyclopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)- 2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1683] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(bicyclo[l.l.l]pentan-l-ylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1684] (1 S,4s)-4-(2-fluoro-4-methoxy-5-((( 1 S,2R,3 S,4R)-3 -(((S)- 1,1,1 -trifluoropropan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid;

[1685] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(tert-butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2- fluoro-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1686] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((l,l,l-trifluoro-2-methylpropan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid; (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((R)-l-

[1687] ((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1688] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((R)-l-

[1689] ((trifluoromethyl)sulfonyl)pyrrolidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1690] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((S)-l-

[1691] ((trifluoromethyl)sulfonyl)pyrrolidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1692] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((S)-l-

[1693] ((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1694] (1 S,4s)-4-(2-fluoro-5-(((l S,2R,3 S,4R)-3 -((3 -fluorobicyclofl .1. l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1695] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-(((l- fluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1696] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((2-methoxy-2- methylpropyl)carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1697] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((2-hydroxy-2- methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1698] (lS,4s)-4-(2-fluoro-5-(((lS,2R,3S,4R)-3-((3-hydroxy-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1 ]heptan-2-yl)carbamoyl)-4-m ethoxyphenoxy)- 1- m ethylcyclohexane- 1 -carboxylic acid;

[1699] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l-

[1700] (trifluoromethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1701] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l-

[1702] (trifluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1703] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((R)-3-cyano-3-methylbutan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l- m ethyl cyclohexane- 1 -carboxylic acid;

[1704] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((S)-3-cyano-3-methylbutan-2- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid;

[1705] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-(((l-ethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1706] (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-((2,2,3,3,3- pentafluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane- 1 -carboxylic acid;

[1707] (lS,4s)-4-(5-(((lS,2R,3S,4R)-3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid; (1 S,4s)-4-(5-(((l S,2R,3 S,4R)-3-(((3,3- difluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1708] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-

[1709] 2-yl)carbamoyl)phenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid;

[1710] (1 S,4s)-4-(2-cyano-5-(((l S,2R,3 S,4R)-3 -((3 -fluorobicyclofl .1. l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1711] (lS,4s)-4-(2-cyano-5-(((lR,2R,3S,4S)-3-((3-fluorobicyclo[l.l. l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid;

[1712] (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3,3- difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l- methylcyclohexane- 1 -carboxylic acid; and

[1713] (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-((3,3,3-trifluoro-2,2- dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid; and pharmaceutically acceptable salts thereof.

[1714] In one embodiment there is provided 4-(2-fluoro-4-methoxy-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1715] In one embodiment there is provided 4-(2-cyano-4-methoxy-5-((3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1716] In one embodiment there is provided 4-(2-cyano-4-methoxy-5-((3-

[1717] (neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1718] In one embodiment there is provided 4-(2-cyano-5-((3-((3-fluorobicyclo[l. l.l]pentan-l- yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-l -methylcyclohexane- 1 -carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1719] In one embodiment there is provided (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)-

[1720] 3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1721] In one embodiment there is provided (lS,4s)-4-(2-cyano-4-methoxy-5-(((l S,2R,3S,4R)-

[1722] 3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid, or a pharmaceutically acceptable salt thereof. In one embodiment there is provided (lS,4s)-4-(2-cyano-4-methoxy-5-(((l S,2R,3S,4R)- 3 -(neopentyl carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1- carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1723] In one embodiment there is provided (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3- fluorobicyclofl .1. l]pentan-l-yl)carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1724] In one embodiment there is provided (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lR,2R,3S,4S)- 3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1725] In one embodiment there is provided (lS,4s)-4-(2-cyano-4-methoxy-5-(((lR,2R,3S,4S)- 3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1726] In one embodiment there is provided (lS,4s)-4-(2-cyano-4-methoxy-5-(((lR,2R,3S,4S)- 3 -(neopentyl carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1- carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1727] In one embodiment there is provided (lS,4s)-4-(2-cyano-5-(((lR,2R,3S,4S)-3-((3- fluorobicyclofl .1. l]pentan-l-yl)carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid, or a pharmaceutically acceptable salt thereof.

[1728] In one embodiment there is provided (lS,4s)-4-(2-fluoro-4-methoxy-5-(((lS,2R,3S,4R)- 3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid.

[1729] In one embodiment there is provided (lS,4s)-4-(2-cyano-4-methoxy-5-(((l S,2R,3S,4R)- 3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- m ethylcyclohexane- 1 -carboxylic acid.

[1730] In one embodiment there is provided (lS,4s)-4-(2-cyano-4-methoxy-5-(((l S,2R,3S,4R)- 3 -(neopentyl carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1- carboxylic acid.

[1731] In one embodiment there is provided (lS,4s)-4-(2-cyano-5-(((lS,2R,3S,4R)-3-((3- fluorobicyclofl .1. l]pentan-l-yl)carbamoyl)bicyclo[2.2. l]heptan-2-yl)carbamoyl)-4- m ethoxyphenoxy)- 1 -methylcyclohexane- 1 -carboxylic acid. In further embodiments there is provided any one of the Example compounds (as named hereinafter in the Experimental section), or a pharmaceutically acceptable salt thereof.

[1732] In further embodiments there is provided any one of the Example compounds (as named hereinafter in the Experimental section).

[1733] The compounds of Formula (I) may be prepared from the Intermediate compounds (as named or shown hereinafter in the Experimental section) using the methods described in the Experimental section. The skilled person will understand that alternative methods may also be used to prepare the compounds of Formula (I) from such Intermediate compounds.

[1734] Accordingly, in further embodiments there is provided any one of the Intermediate compounds (as named or shown hereinafter in the Experimental section).

[1735] Accordingly, in further embodiments there is provided any one of the Intermediate compounds (as named or shown hereinafter in the Experimental section), or a salt thereof.

[1736] Therefore, examples of just some of the above-mentioned embodiments are given below: In one embodiment there is provided Intermediate 75, or a salt thereof.

[1737] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-(5-(((ls,4S)-4-(Tert- butoxycarbonyl)-4-methylcyclohexyl)oxy)-4-fluoro-2- methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid, or a salt thereof.

[1738] In one embodiment there is provided Intermediate 68, or a salt thereof.

[1739] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-(5-(((ls,4S)-4-Carboxy-4- methylcyclohexyl)oxy)-4-cyano-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid, or a salt thereof.

[1740] In one embodiment there is provided (lR,2S,3R,4S)-3-(5-(((ls,4S)-4-Carboxy-4- methylcyclohexyl)oxy)-4-cyano-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid, or a salt thereof.

[1741] In one embodiment there is provided Intermediate 5, or a salt thereof.

[1742] Therefore, in this case, there is provided Methyl 5-(l,3,6,2-dioxazaborocan-2-yl)-4- fluoro-2-methoxybenzoate, or a salt thereof.

[1743] In one embodiment there is provided Intermediate 11, or a salt thereof.

[1744] Therefore, in this case, there is provided Naphthal en-l-ylmethyl (lr,4r)-4-hydroxy-l- methylcyclohexane-1 -carboxylate, or a salt thereof.

[1745] In one embodiment there is provided Intermediate 12, or a salt thereof. Therefore, in this case, there is provided Methyl 4-fluoro-2-methoxy-5-(((ls,4s)-4- methyl-4-((naphthalen-l-ylmethoxy)carbonyl)cyclohexyl)oxy)benzoate, or a salt thereof.

[1746] In one embodiment there is provided Intermediate 35, or a salt thereof.

[1747] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-(4-Cyano-5-hydroxy-2- methoxybenzamido)-7V-((l-methylcyclobutyl)methyl)bicyclo[2.2. l]heptane-2-carboxamide, or a salt thereof.

[1748] In one embodiment there is provided (lS,2S,3R,4R)-3-(4-Cyano-5-hydroxy-2- methoxybenzamido)-7V-((l-methylcyclobutyl)methyl)bicyclo[2.2. l]heptane-2-carboxamide, or a salt thereof.

[1749] In one embodiment there is provided (lR,2S,3R,4S)-3-(4-fluoro-5-hydroxy-2- methoxybenzamido)-N-((l-methylcyclobutyl)methyl)bicyclo[2.2. l]heptane-2-carboxamide, or a salt thereof.

[1750] In one embodiment there is provided (lS,2S,3R,4R)-3-(4-fluoro-5-hydroxy-2- methoxybenzamido)-N-((l-methylcyclobutyl)methyl)bicyclo[2.2. l]heptane-2-carboxamide, or a salt thereof.

[1751] In one embodiment there is provided Intermediate 13, or a salt thereof.

[1752] Therefore, in this case, there is provided 4-Fluoro-2-methoxy-5-(((ls,4s)-4-methyl-4- ((naphthalen-l-ylmethoxy)carbonyl)cyclohexyl)oxy)benzoic acid, or a salt thereof.

[1753] In one embodiment there is provided Intermediate 15, or a salt thereof.

[1754] Therefore, in this case, there is provided Methyl (lS,2S,3R,4R)-3-(4-fluoro-2-methoxy-5- (((ls,4S)-4-methyl-4-((naphthalen-l- ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2. l]hept-5-ene-2-carboxylate, or a salt thereof.

[1755] In one embodiment there is provided Methyl (lR,2S,3R,4S)-3-(4-fluoro-2-methoxy-5- (((ls,4S)-4-methyl-4-((naphthalen-l- ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2. l]hept-5-ene-2-carboxylate, or a salt thereof.

[1756] In one embodiment there is provided Intermediate 16, or a salt thereof.

[1757] Therefore, in this case, there is provided (lS,2S,3R,4R)-3-(4-Fluoro-2-methoxy-5- (((ls,45)-4-methyl-4-((naphthalen-l- ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, or a salt thereof. In one embodiment there is provided (lR,2S,3R,4S)-3-(4-Fluoro-2-methoxy-5-(((ls,45')-

[1758] 4-methyl-4-((naphthalen-l-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-

[1759] 5-ene-2-carboxylic acid, or a salt thereof.

[1760] In one embodiment there is provided Intermediate 584, or a salt thereof.

[1761] Therefore, in this case, there is provided (lS,2S,3R,4R)-3-(4-cyano-2-methoxy-5- (((ls,4S)-4-methyl-4-((naphthalen-l- ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, or a salt thereof.

[1762] In one embodiment there is provided (lR,2S,3R,4S)-3-(4-cyano-2-methoxy-5-(((ls,4S)-

[1763] 4-methyl-4-((naphthalen-l-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-

[1764] 5-ene-2-carboxylic acid, or a salt thereof.

[1765] In one embodiment there is provided Intermediate 20, or a salt thereof.

[1766] Therefore, in this case, there is provided Zc / V-Butyl ((lR,2R,3S,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamate, or a salt thereof.

[1767] In one embodiment there is provided Zc / V-Butyl ((lR,2R,3S,4S)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamate, or a salt thereof.

[1768] In one embodiment there is provided Intermediate 21, or the free base or a salt thereof.

[1769] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-Amino-7V-((l- methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or the free base or a salt thereof.

[1770] In one embodiment there is provided (lS,2S,3R,4R)-3-Amino-7V-((l- methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or the free base or a salt thereof.

[1771] In one embodiment there is provided Intermediate 22, or the free base or a salt thereof.

[1772] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-Amino-A-((l- methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or the free base or a salt thereof.

[1773] In one embodiment there is provided (lS,2S,3R,4R)-3-Amino-A-((l- methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or the free base or a salt thereof.

[1774] In one embodiment there is provided Intermediate 224, or the free base or a salt thereof.

[1775] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-amino-N- neopentylbicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or the free base or a salt thereof. In one embodiment there is provided (lS,2S,3R,4R)-3-amino-N- neopentylbicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or the free base or a salt thereof.

[1776] In one embodiment there is provided Intermediate 223, or the free base or a salt thereof.

[1777] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-amino-N-(3- fluorobicyclofl .1. l]pentan-l-yl)bicyclo[2.2. l]heptane-2-carboxamide hydrochloride, or the free base or a salt thereof.

[1778] In one embodiment there is provided (lS,2S,3R,4R)-3-amino-N-(3- fluorobicyclofl .1. l]pentan-l-yl)bicyclo[2.2. l]heptane-2-carboxamide hydrochloride, or the free base or a salt thereof.

[1779] In one embodiment there is provided Intermediate 73, or a salt thereof.

[1780] Therefore, in this case, there is provided 5-(((ls,4s)-4-(Tert-butoxycarbonyl)-4- methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzoic acid, or a salt thereof.

[1781] In one embodiment there is provided Intermediate 69, or a salt thereof.

[1782] Therefore, in this case, there is provided Methyl 4-cyano-2-methoxy-5-(((ls,4s)-4- methyl-4-((naphthalen-l-ylmethoxy)carbonyl)cyclohexyl)oxy)benzoate, or a salt thereof.

[1783] In one embodiment there is provided Intermediate 70, or a salt thereof.

[1784] Therefore, in this case, there is provided 4-Cyano-2-methoxy-5-(((ls,4s)-4-methyl-4- ((naphthalen-l-ylmethoxy)carbonyl)cyclohexyl)oxy)benzoic acid, or a salt thereof.

[1785] In one embodiment there is provided Intermediate 71, or a salt thereof.

[1786] Therefore, in this case, there is provided Methyl (lS,2S,3R,4R)-3-(4-cyano-2-methoxy-5- (((ls,4S)-4-methyl-4-((naphthalen-l- ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2. l]hept-5-ene-2-carboxylate, or a salt thereof.

[1787] In one embodiment there is provided Methyl (lR,2S,3R,4S)-3-(4-cyano-2-methoxy-5- (((ls,4S)-4-methyl-4-((naphthalen-l- ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2. l]hept-5-ene-2-carboxylate, or a salt thereof.

[1788] In one embodiment there is provided Intermediate 72, or a salt thereof.

[1789] Therefore, in this case, there is provided (lS,4s)-4-(2-Cyano-4-methoxy-5- (((lS,2R,3S,4R)-3-(methoxycarbonyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid, or a salt thereof.

[1790] In one embodiment there is provided (lS,4s)-4-(2-Cyano-4-methoxy-5-(((lR,2R,3S,4S)- 3-(methoxycarbonyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l-methylcyclohexane-l- carboxylic acid, or a salt thereof. In one embodiment there is provided Intermediate 403, or a salt thereof.

[1791] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-(5-(((ls,4S)-4-Carboxy-4- methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid, or a salt thereof.

[1792] In one embodiment there is provided (lS,2S,3R,4R)-3-(5-(((ls,4S)-4-Carboxy-4- methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid, or a salt thereof.

[1793] In one embodiment there is provided Intermediate 127, or a salt thereof.

[1794] Therefore, in this case, there is provided Methyl (lR,2S,3R,4S)-3-(5-bromo-4-fluoro-2- methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylate, or a salt thereof.

[1795] In one embodiment there is provided Methyl (lS,2S,3R,4R)-3-(5-bromo-4-fluoro-2- methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylate, or a salt thereof.

[1796] In one embodiment there is provided Intermediate 128, or a salt thereof.

[1797] Therefore, in this case, there is provided (lR,2S,3R,4S)-3-(5-Bromo-4-fluoro-2- methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid, or a salt thereof.

[1798] In one embodiment there is provided (lS,2S,3R,4R)-3-(5-Bromo-4-fluoro-2- methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid, or a salt thereof.

[1799] In one embodiment there is provided Intermediate 136, or a salt thereof.

[1800] Therefore, in this case, there is provided Benzyl 5-(((l s,4s)-4-( / c77-butoxycarbonyl)-4- methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzoate, or a salt thereof.

[1801] In one embodiment there is provided Intermediate 521, or a salt thereof.

[1802] Therefore, in this case, there is provided (ls,4s)-4-(2-fluoro-4-methoxy-5- (m ethoxy carbonyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid, or a salt thereof.

[1803] In one embodiment there is provided a process for preparing a compound of Formula (I), or pharmaceutically acceptable salt thereof, using an Intermediate compound (as described herein, or named or shown hereinafter in the Experimental section), or a salt thereof.

[1804] In one embodiment there is provided a process for preparing (lS,4s)-4-(2-fluoro-4- methoxy-5-(((lS,2R,3S,4R)-3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid, or pharmaceutically acceptable salt thereof, using an Intermediate compound (as described herein, or named or shown hereinafter in the Experimental section), or a salt thereof.

[1805] In one embodiment there is provided a process for preparing (lS,4s)-4-(2-cyano-4- methoxy-5-(((lS,2R,3S,4R)-3-(((l-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid, or pharmaceutically acceptable salt thereof, using an Intermediate compound (as described herein, or named or shown hereinafter in the Experimental section), or a salt thereof.

[1806] In one embodiment there is provided a process for preparing (lS,4s)-4-(2-cyano-4- methoxy-5-(((lS,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)-l -methylcyclohexane- 1 -carboxylic acid, or pharmaceutically acceptable salt thereof, using an Intermediate compound (as described herein, or named or shown hereinafter in the Experimental section), or a salt thereof.

[1807] In one embodiment there is provided a process for preparing (lS,4s)-4-(2-cyano-5- (((lS,2R,3S,4R)-3-((3-fluorobicyclo[l.l. l]pentan-l-yl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)-4-methoxyphenoxy)-l-methylcyclohexane-l-carboxylic acid, or pharmaceutically acceptable salt thereof, using an Intermediate compound (as described herein, or named or shown hereinafter in the Experimental section), or a salt thereof.

[1808] Terms not specifically defined herein should be understood to have the meanings that would be given to them by one of skill in the art in light of the disclosure and the context. As used in the specification, however, unless specified to the contrary, the following terms have the meaning indicated and the following conventions are adhered to. In the groups defined below, the number of carbon atoms is often specified preceding the group, for example, C1-4alkyl means an alkyl group or radical having 1 to 4 carbon atoms.

[1809] “Alkyl” means a saturated aliphatic branched or straight-chain hydrocarbon group having the specified number of carbon atoms. For example, C1-4alkyl means a group having from 1-4 carbon atoms in a linear or branched arrangement, such as -CH2CH2CH2CH3or -CH2CH(CH3)2. An “Alkylene” is a divalent alkyl group.

[1810] “Alkoxy” means an alkyl group attached through an oxygen linking atom. For example, C1.3alkoxy includes methoxy, ethoxy and propoxy.

[1811] “Aryl” means an aromatic monocyclic or polycyclic hydrocarbon ring system having the specified number of carbon atoms. For example, Ce-io aryl includes groups such as phenyl and naphthalenyl. An “Arylene” is a divalent aryl group.

[1812] “Cycloalkyl” means a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic saturated aliphatic hydrocarbon group having the specified number of carbon atoms. For example, cycloalkyl includes groups such as cyclohexyl, adamantyl, spiro[3.3]heptanyl, bicyclo[2.2.1]heptanyl and decahydronaphthalenyl. As a further example, monocyclic C3-6cycloalkyl means a group having from 3-6 carbon atoms arranged in a monocyclic ring, such as cyclopropyl and cyclohexyl. A “Cycloalkylene” is a divalent cycloalkyl group. “Cycloalkoxy” means a cycloalkyl group attached through an oxygen linking atom. For example, C3-4cycloalkoxy includes cyclopropoxy and cyclobutoxy.

[1813] “Cycloalkenyl” means a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic unsaturated aliphatic hydrocarbon group having the specified number of carbon atoms. For example, cycloalkenyl includes groups such as cyclohexenyl, spiro[4.4]non-2-enyl, bicyclo[2.2.1]hept-2-enyl and l,2,3,4,4a,5,8,8a-octahydronaphthalenyl. As a further example, monocyclic C5-6 cycloalkenyl means a group having from 3-6 carbon atoms arranged in a monocyclic ring, such as cyclopentenyl and cyclohexenyl. A “Cycloalkenylene” is a divalent cycloalkenyl group.

[1814] “Heteroaryl” means an aromatic monocyclic or polycyclic ring system containing carbon atoms and the specified number of heteroatoms (such as O, N or S) in the ring structure, and having the specified total number of atoms in the ring structure. For example, 5- to 10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur includes groups such as indolyl, pyridyl, thiazolyl and oxazolyl. A “Heteroarylene” is a divalent heteroaryl group.

[1815] “Heterocycloalkyl” means a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic saturated group containing carbon atoms and the specified number of heteroatoms (such as O, N or S) in the ring structure, and having the specified total number of atoms in the ring structure. For example, 4- to 8-membered heterocycloalkyl having 1-3 heteroatoms independently selected from oxygen, nitrogen and sulfur includes groups such as pyrrolidinyl, oxetanyl, 2-oxa-6-azaspiro[3.3]heptanyl, hexahydro-2H-thieno[2,3-c]pyrrolyl and 7- oxabicyclo[2.2.1]heptanyl. A “Heterocycloalkylene” is a divalent heterocycloalkyl group.

[1816] “Heterocycloalkenyl” means a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic unsaturated group containing carbon atoms and the specified number of heteroatoms (such as O, N or S) in the ring structure, and having the specified total number of carbon atoms and heteroatoms in the ring structure. For example, 4- to 8-membered heterocycloalkenyl having 1-3 heteroatoms independently selected from oxygen, nitrogen and sulfur includes groups such as 2,5-dihydro-lH-pyrrolyl, 7-oxabicyclo[2.2.1]hept-2-enyl and 4,5,6,6a-tetrahydro-2H- thieno[2,3-c]pyrrol-3-yl. A “Heterocycloalkenylene” is a divalent heterocycloalkenyl group.

[1817] “Heteroalkyl” means an alkyl group, as defined herein, in which one or more of the constituent carbon atoms have been replaced by nitrogen, oxygen, or sulfur. The specified number of members in the heteroalkyl group refers to the total number of carbon atoms and heteroatoms in the chain. For example, -CH2OCH2CH3and -CH2N(CH3)CH2CH3. As a further example, a 4-membered heteroalkyl group containing one heteroatom selected from oxygen and sulfur includes groups such as -CH2OCH2CH3, -SCH(CH3)2, and -CH(CH3)CH2OH. A “Heteroalkylene” is a divalent heteroalkyl group.

[1818] “Halogen” means a fluorine (fluoro), chlorine (chloro), bromine (bromo), or iodine (iodo) radical.

[1819] The chemical names of compounds described in this specification were generated using ChemDraw® Professional version 19.0.0.22 from PerkinElmer®. The skilled person will understand that different chemical naming software may generate different chemical names for a particular compound. In case a compound described herein is depicted in form of a chemical name and as a formula, the formula shall prevail in case of any discrepancy.

[1820] In substituents such as -OH and -CN, denotes the point of attachment of the substituent to the remainder of the molecule. designates the point of attachment of the fragment to the remainder of the molecule.

[1821] The term “pharmaceutically acceptable” is used to specify that an object (for example a salt, dosage form or excipient) is suitable for use in patients. An example list of pharmaceutically acceptable salts can be found in the Handbook of Pharmaceutical Salts: Properties, Selection and Use, P. H. Stahl and C. G. Wermuth, editors, Weinheim / Zurich:Wiley-VCH / VHCA, 2002. A suitable pharmaceutically acceptable salt of a compound of Formula (I) is, for example, an acid-addition salt or a base-addition salt. An acid addition salt of a compound of Formula (I) may be formed by bringing the compound into contact with a suitable inorganic or organic acid under conditions known to the skilled person. An acid addition salt may for example be formed using an inorganic acid selected from the group consisting of hydrochloric acid, hydrobromic acid, sulphuric acid and phosphoric acid. An acid addition salt may also be formed using an organic acid selected from the group consisting of trifluoroacetic acid, citric acid, maleic acid, oxalic acid, acetic acid, formic acid, benzoic acid, fumaric acid, succinic acid, tartaric acid, lactic acid, pyruvic acid, methanesulfonic acid, benzenesulfonic acid and / % / ra-toluenesulfonic acid.

[1822] Therefore, in one embodiment there is provided a compound of Formula (I) or a pharmaceutically acceptable salt thereof, where the pharmaceutically acceptable salt is a hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, trifluoroacetic acid, citric acid, maleic acid, oxalic acid, acetic acid, formic acid, benzoic acid, fumaric acid, succinic acid, tartaric acid, lactic acid, pyruvic acid, methanesulfonic acid, benzenesulfonic acid or para- toluenesulfonic acid salt.

[1823] Compounds described in this specification may form base addition salts. A base-addition salt of a compound of Formula (I) may be formed by bringing the compound into contact with a suitable inorganic or organic base under conditions known to the skilled person. For example, it may be possible to make an alkali metal (such as sodium, potassium, or lithium) or an alkaline earth metal (such as a calcium) salt by treating a compound with an alkali metal or alkaline earth metal hydroxide or alkoxide (e.g., an ethoxide or methoxide) or a suitably basic organic amine (e.g., a choline or meglumine) in an aqueous medium. Therefore, in one embodiment there is provided a compound of Formula (I) or a pharmaceutically acceptable salt thereof, where the pharmaceutically acceptable salt is a sodium, potassium, lithium, calcium, choline or meglumine salt.

[1824] In one embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

[1825] In one embodiment there is provided a compound of Formula (I).

[1826] In one embodiment there is provided a pharmaceutically acceptable salt of a compound of Formula (I).

[1827] Compounds and salts described in this specification may exist in solvated forms and unsolvated forms. For example, a solvated form may be a hydrated form, such as a hemi-hydrate, a mono-hydrate, a di-hydrate, a tri-hydrate or an alternative quantity thereof. All such solvated and unsolvated forms of compounds of Formula (I) are encompassed herein.

[1828] Atoms of the compounds and salts described in this specification may exist as their isotopes. All compounds of Formula (I) where an atom is replaced by one or more of its isotopes (for example a compound of Formula (I) where one or more carbon atom is annC or13C carbon isotope, or where one or more hydrogen atoms is a2H or3H isotope) are encompassed herein.

[1829] Compounds of the application may exist in one or more geometrical, optical, enantiomeric, and diastereomeric forms, including, but not limited to, cis- and trans-forms, E- and Z-forms, and R-, S- and meso-forms. Unless otherwise stated a reference to a particular compound includes all such isomeric forms, including racemic and other mixtures thereof. Where appropriate such isomers can be separated from their mixtures by the application or adaptation of known methods (e.g. chromatographic techniques and recrystallisation techniques). Where appropriate such isomers can be prepared by the application or adaptation of known methods.

[1830] The compounds of Formula (I) may include one or more chiral centres. To the extent a structure or chemical name in this specification does not indicate chirality, the structure or name is intended to encompass any single stereoisomer corresponding to that structure or name, as well as any mixture of stereoisomers (e.g. a racemate). Where a structure in this specification includes bonds drawn as solid and hashed wedges (i.e. ■ it is intended that the solid and hashed wedges indicate the absolute configuration of a chiral centre unless the “or” or “&” chiral flags are present at the chiral centre. Groups of related chiral flags are indicated with the same integer, for example “orl”, “&1”, “or2”, “&2” etc. The skilled person will understand the meaning of chiral flags at a chiral centres. For example, the structure indicates that the compound is a single stereoisomer with the defined absolute configuration. As a further example, the structure indicates that the compound is a single stereoisomer with the defined relative configuration at the flagged chiral centres, but unknown absolute configuration at the flagged chiral centres. As a further example, the structure indicates that the compound is a mixture of stereoisomers having the defined relative configuration at the flagged chiral centres.

[1831] It is well-known in the art how such optically-active forms can be separated. For example, a single stereoisomer can be obtained by isolating it from a mixtures of isomers (e.g. a racemate) using, for example, chiral chromatographic separation. In other embodiments, a single stereoisomer is obtained through direct synthesis from, for example, a chiral starting material. According to one embodiment, there is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof, which is a single enantiomer being in enantiomer excess (%ee) of > 95%, > 98%, or > 99%. Conveniently a single enantiomer is present in an enantiomer excess of > 99%.

[1832] According to one embodiment, there is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof, which is a single enantiomer being in enantiomer excess (%ee) in the range 95 to 100%.

[1833] According to one embodiment, there is provided a pharmaceutical composition, which comprises a compound of Formula (I) which is a single enantiomer being in enantiomer excess (%ee) of > 95%, > 98%, or > 99% or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable diluent or carrier. Conveniently, the single enantiomer is present in an enantiomer excess of > 99%.

[1834] According to one embodiment, there is provided a pharmaceutical composition, which comprises a compound of Formula (I) which is a single enantiomer being in enantiomer excess (%ee) in the range 95 to 100%, or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable diluent or carrier.

[1835] Compounds of the application may exist in one or more tautomeric forms, including, but not limited to, keto-, and enol-forms. A reference to a particular compound includes all tautomeric forms, including mixtures thereof. Accordingly, a structure depicted herein as one tautomer is intended to also include other tautomers.

[1836] The compounds of Formula (I) may be administered in the form of a prodrug, which is a compound which that is broken down in the human or animal body to release the compound of Formula (I). Such, pharmaceutically acceptable, prodrugs of compounds for Formula (I) also form an embodiment. Various forms of prodrugs are known in the art. For example, see a) Design of Pro-drugs, edited by H. Bundgaard, (Elsevier, 1985); b) A Textbook of Drug Design and Development, edited by Krogsgaard-Larsen and H. Bundgaard, Chapter 5 “Design and Application of Pro-drugs”, by H. Bundgaard p. 113-191 (1991); c) H. Bundgaard, Advanced Drug Delivery Reviews, 8, 1-38 (1992); d) H. Bundgaard, et al., Journal of Pharmaceutical Sciences, 77, 285 (1988); and e) N. Kakeya, et al., Chem, Pharm, Bull., 32, 692 (1984).

[1837] In one embodiment there is provided a prodrug of a compound of Formula (I) as herein defined, or a pharmaceutically acceptable salt thereof. In one embodiment there is provided a prodrug of a compound of Formula (I) as herein defined, wherein said prodrug is a compound of Formula (I) as herein defined except that R1is - COO(C1-4alkyl), or a pharmaceutically acceptable salt thereof.

[1838] In one embodiment there is provided an N-oxide of a compound of Formula (I) as herein defined, or a prodrug or pharmaceutically acceptable salt thereof.

[1839] As a result of their modulation of RXFP1, the compounds of Formula (I), and pharmaceutically acceptable salts thereof are expected to be useful in therapy.

[1840] The term “therapy” is intended to have its normal meaning of dealing with a disease or condition in order to entirely or partially relieve one, some or all of its symptoms, or to correct or compensate for the underlying pathology. The term "therapy" also includes "prophylaxis" unless there are specific indications to the contrary. The terms "therapeutic" and "therapeutically" should be interpreted in a corresponding manner.

[1841] The term “prophylaxis” is intended to have its normal meaning and includes primary prophylaxis to prevent the development of the disease or condition and secondary prophylaxis whereby the disease or condition has already developed and the patient is temporarily or permanently protected against exacerbation or worsening of the disease or condition, or the development of new symptoms associated with the disease or condition.

[1842] The term “treatment” is used synonymously with “therapy”. Similarly the term “treat” can be regarded as “applying therapy” where “therapy” is as defined herein.

[1843] Accordingly, the compounds or pharmaceutical compositions described herein may be used in therapy, for example for treating a disease or disorder. Also provided is a method of treating a disease or disorder comprising administering to a subject or patient in need thereof a therapeutically effective amount of the compounds described herein.

[1844] It will be understood that the compounds described herein may be used in the treatment of cardiovascular diseases, for example for the treatment of heart failure.

[1845] As used herein, the term "heart failure" includes acute heart failure, chronic heart failure (CHF) and acute decompensated heart failure (ADHF). The term "heart failure" may also include more specific diagnoses such as heart failure with preserved ejection fraction (HFpEF), heart failure with mid-range ejection fraction or heart failure with reduced ejection fraction (HFrEF).

[1846] The compounds described herein may also be used in the treatment of kidney disease (including chronic kidney disease), acute kidney injury, lung disease and fibrotic disorders, for example fibrotic disorders of the kidney, heart, lung and liver, and in wound healing (Sherwood OD (2004) Endocrine Reviews 25(2): 205-234). The compounds described herein may also be used in the reversal of insulin resistance in diabetic patients (Bonner JS et al. (2013) Diabetes 62(9):3251-3260). The compounds described herein may also be used in the treatment of various forms of pulmonary hypertension. The compounds described herein may also be used in the treatment of disorders that are a result of or a cause of arterial stiffness, reduced arterial elasticity, reduced arterial compliance and distensibility including hypertension, kidney disease, peripheral arterial disease, carotid and cerebrovascular disease (i.e. stroke and dementia), diabetes, microvascular disease resulting in end organ damage, coronary artery disease, and heart failure. The compounds described herein may also be used in the treatment of pre-eclampsia.

[1847] In one embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in therapy.

[1848] In one embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with midrange ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury.

[1849] In one embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of heart failure.

[1850] In one embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, and / or heart failure with reduced ejection fraction.

[1851] In one embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of chronic kidney disease and / or acute kidney injury.

[1852] In one embodiment there is provided the use of the compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment of a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury.

[1853] The term "therapeutically effective amount" refers to an amount of a compound of Formula (I) as described in any of the embodiments herein which is effective to provide “therapy” in a subject, or to “treat” a disease or condition in a subject. The therapeutically effective amount may cause any of the changes observable or measurable in a subject as described in the definition of “therapy”, “treatment” and “prophylaxis” above. As recognized by those skilled in the art, effective amounts may vary depending on route of administration, excipient usage, and co-usage with other agents. For example, where a combination therapy is used, the amount of the compound of Formula (I) or pharmaceutically acceptable salt described in this specification and the amount of the other pharmaceutically active agent(s) are, when combined, jointly effective to treat a targeted disorder or condition in the subject. In this context, the combined amounts are in a “therapeutically effective amount” if they are, when combined, sufficient to decrease the symptoms of a disease or condition responsive to modulation and / or agonism of RXFP1 as described above. Typically, such amounts may be determined by one skilled in the art by, for example, starting with the dosage range described in this specification for the compound of Formula (I) or pharmaceutically acceptable salt thereof and an approved or otherwise published dosage range(s) of the other pharmaceutically active compound(s).

[1854] “Subjects” include, for example, mammals, for example, humans.

[1855] In one embodiment there is provided a method for treating a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury.

[1856] The compounds of Formula (I), and pharmaceutically acceptable salts thereof, may be administered as pharmaceutical compositions, comprising one or more pharmaceutically acceptable excipients.

[1857] Therefore, in one embodiment there is provided a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

[1858] The excipient(s) selected for inclusion in a particular composition will depend on factors such as the mode of administration and the form of the composition provided. Suitable pharmaceutically acceptable excipients are well known to persons skilled in the art and are described, for example, in the Handbook of Pharmaceutical Excipients, Sixth edition, Pharmaceutical Press, edited by Rowe, Ray C; Sheskey, Paul J; Quinn, Marian. Pharmaceutically acceptable excipients may function as, for example, adjuvants, diluents, carriers, stabilisers, flavourings, colorants, fillers, binders, disintegrants, lubricants, glidants, thickening agents and coating agents. As persons skilled in the art will appreciate, certain pharmaceutically acceptable excipients may serve more than one function and may serve alternative functions depending on how much of the excipient is present in the composition and what other excipients are present in the composition. The pharmaceutical compositions may be in a form suitable for oral use (for example as tablets, lozenges, hard or soft capsules, aqueous or oily suspensions, emulsions, dispersible powders or granules, syrups or elixirs), for topical use (for example as creams, ointments, gels, or aqueous or oily solutions or suspensions), for administration by inhalation (for example as a finely divided powder or a liquid aerosol), for administration by insufflation (for example as a finely divided powder) or for parenteral administration (for example as a sterile aqueous or oily solution for intravenous, subcutaneous, intramuscular or intramuscular dosing), or as a suppository for rectal dosing. The compositions may be obtained by conventional procedures well known in the art. Compositions intended for oral use may contain additional components, for example, one or more colouring, sweetening, flavouring and / or preservative agents.

[1859] The compound of Formula (I) will normally be administered to a subject at a unit dose within the range 2.5-5000 mg / m2body area of the subject, or approximately 0.05-100 mg / kg, and this normally provides a therapeutically-effective dose. A unit dose form such as a tablet or capsule will usually contain, for example 0.1-400 mg of active ingredient. The daily dose will necessarily be varied depending upon the host treated, the particular route of administration, any therapies being co-administered, and the severity of the disease or condition being treated.

[1860] The pharmaceutical compositions described herein comprise compounds of Formula (I), or a pharmaceutically acceptable salt thereof, and are therefore expected to be useful in therapy.

[1861] As such, in one embodiment there is provided a pharmaceutical composition for use in therapy, comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

[1862] In the formulation of drug compositions, it is important for the drug substance to be in a form in which it can be conveniently handled and processed. This is of importance, not only from the point of view of obtaining a commercially viable manufacturing process, but also from the point of view of subsequent manufacture of pharmaceutical formulations (e.g. oral dosage forms such as tablets) comprising the active compound.

[1863] The different physical properties of the crystalline forms with respect to each other and with respect to the non-crystalline state may influence markedly the chemical and pharmaceutical processing of a compound, particularly when the compound is prepared or used on an industrial scale.

[1864] Further, in the manufacture of oral drug compositions, it is important that a reliable and reproducible plasma concentration profile of drug is provided following administration to a patient. Inter-patient variability in the absorption profile of a drug within the stomach, intestine or bloodstream can have an effect on drug safety and efficacy.

[1865] Chemical stability, solid state stability and “shelf life” of the active ingredients are also very important factors. The drug substance, and compositions containing it, should be capable of being effectively stored over appreciable periods of time, without exhibiting a significant change in the active component’s physico-chemical characteristics (e.g. its chemical composition, density, hygroscopicity and solubility).

[1866] Moreover, it is also important to be able to provide drug in a form which is as chemically pure as possible.

[1867] Amorphous materials may present problems in this regard. For example, such materials are typically difficult to handle and to formulate, provide for unreliable solubility, and are often found to be unstable and chemically impure.

[1868] The skilled person will appreciate that, if a drug can be readily obtained in a stable crystalline form, the above problems may be solved.

[1869] Thus, in the manufacture of commercially viable, and pharmaceutically acceptable, drug compositions, it is important, wherever possible, to provide drug in a crystalline, and stable, form.

[1870] It is to be noted, however, that this goal is not always achievable. Indeed, typically, it is not possible to predict, from molecular structure alone, what the crystallisation behaviour of a compound, either as such or in the form of a salt, will be. This can only be determined empirically.

[1871] In one embodiment, certain compounds and salts thereof may be prepared in crystalline forms. These crystalline forms may be characterised as being a particular polymorphic form. When it is stated that an embodiment relates to a crystalline form, the degree of crystallinity is conveniently greater than about 60%, more conveniently greater than about 80%, preferably greater than about 90% and more preferably greater than about 95%. Most preferably the degree of crystallinity is greater than about 98%.

[1872] The specific solid forms described herein provide X-ray powder diffraction patterns substantially the same as the X-ray powder diffraction patterns shown in the Figures and have the various 2-theta values as described herein. It will be understood that the 2-theta values of a X-ray powder diffraction pattern may vary slightly from one machine to another or from one sample to another, and so the values quoted are not to be construed as absolute.

[1873] It is known that an X-ray powder diffraction pattern may be obtained which has one or more measurement errors depending on measurement conditions (such as equipment or machine used). In particular, it is generally known that intensities in an X-ray powder diffraction pattern may fluctuate depending on measurement conditions. Therefore it should be understood that the solid forms described herein are not limited to the crystals that provide X-ray powder diffraction patterns that are identical to the X-ray powder diffraction pattern shown in the Figures, and any crystals providing X-ray powder diffraction patterns substantially the same as those shown in the Figures fall within the scope of the embodiments described herein. A person skilled in the art of X-ray powder diffraction is able to judge the substantial identity of X-ray powder diffraction patterns.

[1874] Persons skilled in the art of X-ray powder diffraction will realise that the relative intensity of peaks can be affected by, for example, grains above 30μm in size and non-unitary aspect ratios, which may affect analysis of samples. The skilled person will also realise that the position of reflections can be affected by the precise height at which the sample sits in the diffractometer and the zero calibration of the diffractometer. The surface planarity of the sample may also have a small effect. Hence the diffraction pattern data presented are not to be taken as absolute values. (Jenkins, R & Snyder, R.L. ‘Introduction to X-Ray Powder Diffractometry’ John Wiley & Sons 1996; Bunn, C.W. (1948), Chemical Crystallography, Clarendon Press, London; Klug, H. P. & Alexander, L. E. (1974), X-Ray Diffraction Procedures). The peak intensities are described herein as vs (very strong), s (strong), m (medium) and w (weak) and correspond to % relative intensity (based on the most intense peak) of 25-100%, 10-25%, 3-10% and 1-3%, respectively. The relative intensities are derived from diffractograms measured with fixed slits.

[1875] Generally, a measurement error of a diffraction angle in an X-ray powder diffractogram is about 5% or less, in particular plus or minus 0.5° 2-theta, and such degree of a measurement error should be taken into account when considering the X-ray powder diffraction patterns in the Figures herein when reading the data described herein. Furthermore, it should be understood that intensities may fluctuate depending on experimental conditions and sample preparation (preferred orientation).

[1876] The X-ray powder diffraction analysis was performed according to standard methods, which can be found in e.g. Kitaigorodsky, A.I. (1973), Molecular Crystals and Molecules, Academic Press, New York; Bunn, C.W. (1948), Chemical Crystallography, Clarendon Press, London; or Klug, H.P. & Alexander, L.E. (1974), X-ray Diffraction Procedures, John Wiley & Sons, New York.

[1877] X-ray powder diffraction data was measured with Corundum as an internal reference. The X-ray powder diffraction (referred to herein as XRPD) pattern was determined by mounting a sample on a zero background holder single silicon crystal and spreading out the sample into a thin layer.

[1878] The powder X-ray diffraction was recorded with a theta-two theta scan axis and in one dimensional scan with Rigaku Miniflex 600 (wavelength of X-rays 1.5418 A nickel -filtered Cu K α radiation, 40 kV, 15 mA) equipped with D / Tex detector. Automatic variable divergence and anti scattering slits were used, and the samples were rotated at 80 revolution per minute during measurement. Samples were scanned from 2.4 - 50° 2-theta using a 0.01° and l° / min step width and scan speed respectively.

[1879] In this specification (lS,4s)-4-(2-Fluoro-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid (Example 1) is also referred to as “Compound X”. Several useful crystalline polymorphic forms have subsequently been produced using the conditions described in Example 1. In all of the embodiments relating to solid forms recited herein, the peaks of the X-ray diffraction patterns are measured using Cu K α radiation.

[1880] Therefore in one embodiment there is provided polymorphic Form A of Compound X. This polymorphic form may be characterised in that it provides at least one of the following 20 values measured using Cu K α radiation: 7.5, 10.7, 12.8, 14.5 and 15.8°.

[1881] Polymorphic Form A of Compound X is characterised in providing an X-ray powder diffraction pattern, substantially as shown in Figure 1.

[1882] The ten most prominent X-Ray powder diffraction peaks for this polymorphic form [Angle 2-theta (29), Intensity] are: 7.5 (s), 10.3 (m), 10.7 (s), 12.8 (s), 14.5 (vs), 15.3 (s), 15.8 (s), 17.5 (m), 19.6 (s) and 21.3 (s).

[1883] In one embodiment there is provided the polymorphic Form A of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks at about 2-theta = 7.5,

[1884] 10.7, 12.8, 14.5 and 15.8°.

[1885] In one embodiment there is provided the polymorphic Form A of Compound X, which has an X-ray powder diffraction pattern with specific peaks at about 2-theta = 7.5, 10.3, 10.7,

[1886] 12.8, 14.5, 15.3, 15.8, 17.5, 19.6, and 21.3°.

[1887] In one embodiment there is provided polymorphic Form A of Compound X which has an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern shown in Figure 1. In one embodiment there is provided polymorphic Form A of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks at 2-theta = 7.5, 10.7, 12.8, 14.5 and 15.8° wherein said values may be plus or minus 0.2° 2-theta.

[1888] In one embodiment there is provided a polymorphic Form A of Compound X, which has an X-ray powder diffraction pattern with with specific peaks at 2-theta = 7.5, 10.3, 10.7, 12.8,

[1889] 14.5, 15.3, 15.8, 17.5, 19.6, and 21.3° wherein said values may be plus or minus 0.2° 2-theta.

[1890] In one embodiment there is provided polymorphic Form B of Compound X. This polymorphic form may be characterised in that it provides at least one of the following 20 values measured using Cu K α radiation: 6.9, 8.2, 9.2, 11.5, and 15.9°.

[1891] Polymorphic Form B of Compound X is characterised in providing an X-ray powder diffraction pattern, substantially as shown in Figure 2.

[1892] The ten most prominent X-Ray powder diffraction peaks for this polymorphic form [Angle 2-theta (29), Intensity] are: 6.9 (vs), 8.2 (vs), 9.2 (vs), 9.6 (s), 11.5 (s), 12.3 (vs), 13.0 (m), 15.9 (vs), 16.3 (s) and 23.1 (vs).

[1893] In one embodiment there is provided the polymorphic Form B of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks at about 2-theta = 6.9, 8.2, 9.2, 11.5, and 15.9°.

[1894] In one embodiment there is provided the polymorphic Form B of Compound X, which has an X-ray powder diffraction pattern with specific peaks at about 2-theta = 6.9, 8.2, 9.2, 9.6,

[1895] 11.5, 12.3, 13.0, 15.9, 16.3, and 23.1°.

[1896] In one embodiment there is provided polymorphic Form B of Compound X which has an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern shown in Figure 2.

[1897] In one embodiment there is provided polymorphic Form B of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks at 2-theta = 6.9, 8.2, 9.2,

[1898] 11.5, and 15.9° wherein said values may be plus or minus 0.2° 2-theta.

[1899] In one embodiment there is provided a polymorphic Form B of Compound X, which has an X-ray powder diffraction pattern with with specific peaks at 2-theta = 6.9, 8.2, 9.2, 9.6, 11.5, 12.3, 13.0, 15.9, 16.3, and 23.1° wherein said values may be plus or minus 0.2° 2-theta.

[1900] In one embodiment there is provided polymorphic Form D of Compound X. This polymorphic form may be characterised in that it provides at least one of the following 20 values measured using Cu K α radiation: 7.0, 7.7, 14.0, 16.1 and 16.9°. Polymorphic Form D of Compound X is characterised in providing an X-ray powder diffraction pattern, substantially as shown in Figure 3.

[1901] The ten most prominent X-Ray powder diffraction peaks for this polymorphic form [Angle 2-theta (29), Intensity] are: 7.0 (m), 7.7 (vs), 14.0 (vs), 15.0 (m), 16.1 (vs), 16.9 (vs), 18.3 (s), 19.4 (vs), 20.2 (s) and 20.9 (vs).

[1902] In one embodiment there is provided the polymorphic Form D of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks at about 2-theta = 7.0, 7.7, 14.0, 16.1 and 16.9°.

[1903] In one embodiment there is provided the polymorphic Form D of Compound X, which has an X-ray powder diffraction pattern with specific peaks at about 2-theta = 7.0, 7.7, 14.0, 15.0, 16.1, 16.9, 18.3, 19.4, 20.2, and 20.9°.

[1904] In one embodiment there is provided polymorphic Form D of Compound X which has an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern shown in Figure 3.

[1905] In one embodiment there is provided polymorphic Form D of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks at 2-theta = 7.0, 7.7, 14.0, 16.1 and 16.9° wherein said values may be plus or minus 0.2° 2-theta.

[1906] In one embodiment there is provided a polymorphic Form D of Compound X, which has an X-ray powder diffraction pattern with with specific peaks at 2-theta = 7.0, 7.7, 14.0, 15.0, 16.1, 16.9, 18.3, 19.4, 20.2, and 20.9° wherein said values may be plus or minus 0.2° 2-theta.

[1907] In one embodiment there is provided polymorphic Form E of Compound X. This polymorphic form may be characterised in that it provides at least one of the following 20 values measured using Cu K α, radiation: 6.1, 7.5, 8.2, 14.5 and 15.6°.

[1908] Polymorphic Form E of Compound X is characterised in providing an X-ray powder diffraction pattern, substantially as shown in Figure 4.

[1909] The ten most prominent X-Ray powder diffraction peaks for this polymorphic form [Angle 2-theta (29), Intensity] are: 6.1 (vs), 7.5 (m), 8.2 (m), 9.4 (m), 19.3 (m), 19.7 (m), 14.5 (s), 15.6 (vs), 16.4 (s) and 29.1 (s).

[1910] In one embodiment there is provided the polymorphic Form E of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks at about 2-theta = 6.1, 7.5, 8.2, 14.5 and 15.6°. In one embodiment there is provided the polymorphic Form E of Compound X, which has an X-ray powder diffraction pattern with specific peaks at about 2-theta = 6.1, 7.5, 8.2, 9.4, 10.3, 10.7, 14.5, 15.6, 16.4, and 20.1°.

[1911] In one embodiment there is provided polymorphic Form E of Compound X which has an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern shown in Figure 4.

[1912] In one embodiment there is provided polymorphic Form E of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks at 2-theta = 6.1, 7.5, 8.2, 14.5 and 15.6° wherein said values may be plus or minus 0.2° 2-theta.

[1913] In one embodiment there is provided a polymorphic Form E of Compound X, which has an X-ray powder diffraction pattern with with specific peaks at 2-theta = 6.1, 7.5, 8.2, 9.4, 10.3, 10.7, 14.5, 15.6, 16.4, and 20.1° wherein said values may be plus or minus 0.2° 2-theta.

[1914] In this specification (lS,4s)-4-(2-cyano-4-methoxy-5-(((lS,2R,3S,4R)-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-l- methylcyclohexane-1 -carboxylic acid (Example 592) is also referred to as “Compound Y”. Several useful crystalline polymorphic forms have subsequently been produced using the conditions described in Example 592. In all of the embodiments relating to solid forms recited herein, the peaks of the X-ray diffraction patterns are measured using Cu K α radiation.

[1915] Therefore in one embodiment there is provided polymorphic Form A of Compound Y. This polymorphic form may be characterised in that it provides at least one of the following 20 values measured using Cu K α radiation: 6.7, 10.5, 13.5, 15.2 and 18.6°.

[1916] Polymorphic Form A of Compound Y is characterised in providing an X-ray powder diffraction pattern, substantially as shown in Figure 5.

[1917] The ten most prominent X-Ray powder diffraction peaks for this polymorphic form [Angle 2-theta (29), Intensity] are: 6.7 (m), 10.5 (vs), 11.8 (m), 13.5 (s), 14.1 (m), 15.2 (s), 16.0 (m), 16.8 (s), 18.6 (vs) and 19.8 (vs).

[1918] In one embodiment there is provided the polymorphic Form A of Compound Y, which has an X-ray powder diffraction pattern with at least five specific peaks at about 2-theta = 6.7,

[1919] 10.5, 13.5, 15.2 and 18.6°.

[1920] In one embodiment there is provided the polymorphic Form A of Compound Y, which has an X-ray powder diffraction pattern with specific peaks at about 2-theta = 6.7, 10.5, 11.8,

[1921] 13.5, 14.1, 15.2, 16.0, 16.8, 18.6, and 19.8°. In one embodiment there is provided polymorphic Form A of Compound Y which has an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern shown in Figure 5.

[1922] In one embodiment there is provided polymorphic Form A of Compound Y, which has an X-ray powder diffraction pattern with at least five specific peaks at 2-theta = 6.7, 10.5, 13.5,

[1923] 15.2 and 18.6° wherein said values may be plus or minus 0.2° 2-theta.

[1924] In one embodiment there is provided a polymorphic Form A of Compound Y, which has an X-ray powder diffraction pattern with with specific peaks at 2-theta = 6.7, 10.5, 11.8, 13.5,

[1925] 14.1, 15.2, 16.0, 16.8, 18.6, and 19.8° wherein said values may be plus or minus 0.2° 2-theta.

[1926] Therefore in one embodiment there is provided polymorphic Form B of Compound Y. This polymorphic form may be characterised in that it provides at least one of the following 20 values measured using Cu Ak radiation: 6.0, 7.6, 8.6, 19.0 and 20.2°.

[1927] Polymorphic Form B of Compound Y is characterised in providing an X-ray powder diffraction pattern, substantially as shown in Figure 6.

[1928] The ten most prominent X-Ray powder diffraction peaks for this polymorphic form [Angle 2-theta (29), Intensity] are: 6.0 (m), 7.6 (m), 8.6 (s), 9.5 (vs), 9.7 (vs), 17.2 (s), 19.0 (s),

[1929] 20.2 (s), 23.2 (m) and 23.9 (s).

[1930] In one embodiment there is provided the polymorphic Form B of Compound Y, which has an X-ray powder diffraction pattern with at least five specific peaks at about 2-theta = 6.0,

[1931] 7.6, 8.6, 19.0 and 20.2°.

[1932] In one embodiment there is provided the polymorphic ...

Claims

CLAIMS 1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, whereinRing B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; or a 4- to 10-membered cycloalkenyl; R7is selected from -H, -F, -CH3and -OCH3; each R8is independently selected from C1-4alkyl substituted with 0-3 -F substituents; C1-4 alkoxy; -OH; -F; and -COO(C1-4 alkyl); p is 0, 1 or 2; Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; a 4- to 10-membered cycloalkenyl; or a 4- to 10-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen; each R9is independently selected from C1-4alkyl, C1-4alkoxy, -halo and -OH; q is 0, 1 or 2;R1is selected from -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, - ,X is selected from a bond, -CH2-, -O-, -S-, -CH2O- and -OCH2-; Y is selected from C2-6 alkylene substituted with 0-2 R14substituents; C3-8 cycloalkylene substituted with 0-2 R14substituents; C5-8cycloalkenylene substituted with 0-2 R14substituents; 5- to 8-membered heterocycloalkylene having 1-3 heteroatoms independently selected from oxygen and sulfur and substituted with 0-2 R14substituents; phenylene substituted with 0-2 R14substituents; 5- or 6-membered heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-2 R14substituents; andR14is selected from C1-3alkyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; C1-3alkoxy substituted with 0-3 -F substituents; cyclopropyl substituted with 0-3 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe; and - NMe2; Z is selected from a bond; C1-3alkylene substituted with 0-2 substituents selected from - Me, -NH2, -NHMe and -NMe2; C2-4heteroalkylene having one heteroatom selected from nitrogen and oxygen and substituted with 0-2 substituents selected from -Me, -NH2, -NHMe and -NMe2; C3-4cycloalkylene; and -CH=CH-; R5is selected from -H, -Me and -F; R6is -(CR10R11)nR12; n is 0, 1 or 2; R10and R11are each independently selected from -H, -Me and -F, or R10and R11together with the carbon to which they are attached form cyclopropyl;R12is selected from C3-8alkyl substituted with 0-5 substituents selected from -OH, -F, - CN, and C1-4 alkoxy; C3-10 cycloalkyl substituted with 0-4 R13substituents; 5- to 10-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-4 R13substituents; phenyl substituted with 0-3 substituents selected from - halo, C1-4 alkyl substituted with 0-3 -F substituents, C3-5 cycloalkyl, -CN, -SF5, -OMe, -OCH2F, - OCHF2, -OCF3 and -SO2CF3; 6-membered heteroaryl having 1-2 nitrogen heteroatoms and substituted with 1-3 substituents selected from -halo, -SF5, -CF3, -OCF3and -SO2CF3;each R13is independently selected from -OH; -F; -CN; C1-4 alkoxy substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; and C1-4alkyl substituted with 0-3 substituents selected from -F, -OH, -OMe and -OEt; U, V and W are each independently selected from C and N; provided that when U is N, R2is absent; when V is N, R3is absent; and when W is N, R4is absent; and wherein (i) R2, R3and R4are each independently selected from -H, -halo, -CN, C1-4 alkyl substituted with 0-3 substituents selected from -F and -OMe, C1-4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me; or (ii) U and V are each C; R2and R3, together with the atoms to which they are attached, form a 5- or 6-membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-3 -Me substituents; and R4is selected from -H, -halo, -CN, C1-4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1-4 alkoxy substituted with 0-3 substituents selected from -F and - OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me; or (iii) V and W are each C; R3and R4, together with the atoms to which they are attached, form a 5- or 6- membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur and substituted with 0-3 -Me substituents; andR2is selected from -H, -halo, -CN, C1-4alkyl substituted with 0-3 substituents selected from -F and -OMe, C1-4 alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me; wherein cycloalkyl is a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic saturated aliphatic hydrocarbon group having the specified number of carbon atoms; cycloalkoxy is a cycloalkyl group attached through an oxygen linking atom; cycloalkenyl is a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic unsaturated aliphatic hydrocarbon group having the specified number of carbon atoms; heterocycloalkyl is a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic saturated group containing carbon atoms and the specified number of heteroatoms in the ring structure, and having the specified total number of atoms in the ring structure; heterocycloalkenyl is a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic unsaturated group containing carbon atoms and the specified number of heteroatoms in the ring structure, and having the specified total number of carbon atoms and heteroatoms in the ring structure; heteroalkyl is an alkyl group in which one or more of the constituent carbon atoms have been replaced by nitrogen, oxygen, or sulfur, and the specified number of members in the heteroalkyl group refers to the total number of carbon atoms and heteroatoms in the chain.

2. The compound of claim 1, wherein Ring B is a monocyclic 5- to 7-membered cycloalkyl optionally bridged with C1-3alkylene; a monocyclic 5- to 7-membered heterocycloalkyl having 1-2 heteroatoms independently selected from nitrogen and oxygen and optionally bridged with C1-3alkylene; a monocyclic 5- to 7-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen and optionally bridged with C1-3alkylene; or a monocyclic 5- to 7-membered cycloalkenyl optionally bridged with C1-3alkylene; and Ring C is phenyl; a monocyclic 5- or 6-membered heteroaryl having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur; a monocyclic 4- to 7-membered cycloalkenyl optionally bridged with C1-3alkylene; or a monocyclic 4- to 7-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen and optionally bridged with C1-3alkylene.

3. The compound of claim 1, wherein Ring B is a mono- or poly-cyclic 4- to 10-membered cycloalkyl optionally bridged with C1-3alkylene, or a mono- or poly-cyclic 4- to 10- membered cycloalkenyl optionally bridged with C1-3alkylene.

4. The compound of claim 1, wherein Ring B is a monocyclic 5- to 7-membered cycloalkyl optionally bridged with C1-3alkylene; or a monocyclic 5- to 7-membered cycloalkenyl optionally bridged with C1-3alkylene.

5. The compound of claim 1, wherein Ring B is cyclohexyl 1,4-bridged with C1-2alkylene, or cyclohexenyl 1,4-bridged with C1-2alkylene.

6. The compound of claim 1, wherein Ring B is bicyclo[2.2.1]heptanyl.

7. The compound of any one of the preceding claims, wherein each R8is independently selected from C1-2alkyl substituted with 0-3 -F substituents; C1-2alkoxy; -OH; and -F.

8. The compound of any one of the preceding claims, wherein p is 0 or 1.

9. The compound of any one of the preceding claims, wherein p is 0.

10. The compound of any one of the preceding claims, wherein R7is -H.

11. The compound of any one of the preceding claims, wherein Ring C is phenyl; a monocyclic 5- or 6-membered heteroaryl having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur; a monocyclic 4- to 7-membered cycloalkenyl optionally bridged with C1-3alkylene; or a monocyclic 4- to 7-membered heterocycloalkenyl having 1-2 heteroatoms independently selected from nitrogen and oxygen and optionally bridged with C1-3alkylene.

12. The compound of any one of claims 1-10, wherein Ring C is a mono- or poly-cyclic 6- to 10-membered aryl.

13. The compound of any one of the preceding claims, wherein each R9is independently selected from C1-2alkyl, C1-2alkoxy, -halo and -OH.

14. The compound of any one of the preceding claims, wherein q is 0 or 1.

15. The compound of any one of claims 1-10, wherein A is.

16. The compound of any one of claims 1-14, wherein A is.

17. The compound of any one of claims 1-10, wherein.

18. The compound of any one of claims 1-10, wherein A is selected from,.

19. The compound of any one of claims 1-10, wherein A is selected from.

20. The compound of any one of claims 1-10, wherein A is.

21. The compound of any one of claims 1-10, wherein.

22. The compound of any one of claims 11-14, wherein.

23. The compound of any one of claims 11-14, wherein.

24. The compound of any one of the preceding claims, wherein R1is -COOH.

25. The compound of any one of the preceding claims, wherein X is selected from a bond, - CH2-, and -O-.

26. The compound of any one of the preceding claims, wherein X is -O-.

27. The compound of any one of the preceding claims, wherein Y is selected from C2-4 alkylene substituted with 0-2 R14substituents; C3-8cycloalkylene substituted with 0-2 R14substituents; and 5- to 8-membered heterocycloalkylene having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-2 R14substituents.

28. The compound of any one of the preceding claims, wherein Y is29. The compound of any one of the preceding claims, wherein Y is.

30. The compound of any one of the preceding claims, wherein Y is.

31. The compound of any one of the preceding claims, wherein R14is selected from -H, -Me, -Et, -F, -OH, =O, -OMe, -OEt, -CF3, -CH2OH, -CH2OMe, -CN, -CH2CN, -NH2, -NHMe and -NMe2.

32. The compound of any one of the preceding claims, wherein R14is not -H.

33. The compound of any one of the preceding claims, wherein R14is -Me.

34. The compound of any one of the preceding claims, wherein Z is selected from a bond, - CH2-, -CH2CH2-, -OCH2-, -CH2O-, -C(CH3)2O-, -CH2CH2O-, -CH2CH2CH2O-, -CH2NH- , -CH(NH2)-, -CH(NMe2)-, -CH2CH(NMe2)-, -CH(NMe2)CH2-, -CH2CH(NH2)-, -35. The compound of any one of the preceding claims, wherein Z is a bond.

36. The compound of any one of the preceding claims, wherein R5is -H.

37. The compound of any one of the preceding claims, wherein n is 0 or 1.

38. The compound of any one of the preceding claims, wherein n is 1.

39. The compound of any one of the preceding claims, wherein R10and R11are each -H.

40. The compound of any one of the preceding claims, wherein R12is selected from C4-6 alkyl substituted with 0-3 substituents selected from -F, -CN, and C1-2alkoxy; C4-6cycloalkyl substituted with 0-3 R13substituents; and 5- to 6-membered heterocycloalkyl having 1-2 heteroatoms independently selected from oxygen and sulfur and substituted with 0-3 R13substituents.

41. The compound of any one of the preceding claims, wherein R12is selected from, -CF3 and -CN.

42. The compound of any one of claims 1-40, wherein R12is selected from43. The compound of any one of claims 1-40, wherein R12is selected from.

44. The compound of any one of claims 1-40, wherein.

45. The compound of any one of claims 1-40, wherein each R13is independently selected from -F; -CN; C1-2alkoxy substituted with 0-1 substituents selected from -F, -OMe and - OEt; and C1-2alkyl substituted with 0-1 substituents selected from -F, -OMe and -OEt.

46. The compound of any one of claims 1-40, wherein each R13is -Me.

47. The compound of any one of claims 1-36, wherein R6is selected from48. The compound of any one of claims 1-36, wherein R6is selected from.

49. The compound of any one of claims 1-36, wherein.

50. The compound of any one of the preceding claims, wherein U, V and W are each C.

51. The compound of any one of the preceding claims, wherein R2, R3and R4are each independently selected from -H, -halo, -CN, C1-4 alkyl substituted with 0-3 substituentsselected from -F and -OMe, C1-4alkoxy substituted with 0-3 substituents selected from -F and -OMe, C3-4cycloalkyl substituted with 0-3 substituents selected from -F and -OMe, and C3-4cycloalkoxy substituted with 0-3 substituents selected from -F and -Me.

52. The compound of any one of the preceding claims, wherein R2is selected from -H, -halo, -CN, C1-2alkyl substituted with 0-3 -F substituents, C1-2alkyl substituted with 0-1 -OMe substituents, and cyclopropyl.

53. The compound of any one of the preceding claims, wherein R2is -CN or -F.

54. The compound of any one of the preceding claims, wherein R3is selected from -H, -halo, -CN, C1-2alkyl substituted with 0-3 -F substituents, C1-2alkyl substituted with 0-1 -OMe substituents, and cyclopropyl.

55. The compound of any one of the preceding claims, wherein R3is -H.

56. The compound of any one of the preceding claims, wherein R4is selected from -F and C1- 4 alkoxy substituted with 0-3 substituents selected from -F and -OMe.

57. The compound of any one of the preceding claims, wherein R4is -OMe.

58. The compound of any one of claims 1-50, wherein R2is -CN; R3is -H; R4is -OMe; and R5is -H.

59. The compound of any one of claims 1-50, wherein R2is -F; R3is -H; R4is -OMe; and R5is -H.

60. The compound of any one of claims 1 and 37-53, wherein the compound is of Formula (IIa) or Formula (IIb):(Formula IIa) (Formula IIb)or a pharmaceutically acceptable salt thereof.

61. The compound of any one of claims 1 and 37-53, wherein the compound is of Formula (IIIa) or Formula (IIIb):or a pharmaceutically acceptable salt thereof.

62. The compound of claim 61, wherein the compound is of Formula (IIIa) or a pharmaceutically acceptable salt thereof.

63. The compound of any one of claims 1-36 and 50-62, wherein R2is -F or -CN; and R6is64. The compound of claim 1, wherein the compound isacceptable salt thereof.

65. The compound of claim 1, wherein the compound ispharmaceutically acceptable salt thereof.

66. The compound of claim 1, wherein the compound ispharmaceutically acceptable salt thereof.

67. The compound of claim 1, wherein the compound ispharmaceutically acceptable salt thereof.

68. The compound of claim 1, wherein the compound ispharmaceutically acceptable salt thereof.

69. The compound of claim 1, wherein the compound ispharmaceutically acceptable salt thereof.

70. The compound of claim 1, wherein the compound isacceptable salt thereof.

71. The compound of claim 1, wherein the compound ispharmaceutically acceptable salt thereof.

72. The compound of claim 1, wherein the compound is (1S,4s)-4-(2-fluoro-4-methoxy-5- (((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid, or a pharmaceutically acceptable salt thereof.

73. The compound of claim 1, wherein the compound is (1S,4s)-4-(2-cyano-4-methoxy-5- (((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2- yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid, or a pharmaceutically acceptable salt thereof.

74. The compound of claim 1, wherein the compound is (1S,4s)-4-(2-cyano-4-methoxy-5- (((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)- 1-methylcyclohexane-1-carboxylic acid, or a pharmaceutically acceptable salt thereof.

75. The compound of claim 1, wherein the compound is (1S,4s)-4-(2-cyano-5- (((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan- 2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid, or a pharmaceutically acceptable salt thereof.

76. A pharmaceutical composition comprising the compound of any one of the preceding claims and a pharmaceutically acceptable excipient.

77. The compound of any one of claims 1-75 for use in therapy.

78. The compound of any one of claims 1-75 for use in the treatment of a subject with a disease or condition selected from the group consisting of heart failure, heart failure withpreserved ejection fraction, heart failure with mid-range ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury.

79. A crystalline form of the compound having the formula:.

80. The crystalline form of claim 79, which has an X-ray powder diffraction pattern (Cu K ^ radiation) with at least five specific peaks at about 2-theta = 7.5, 10.7, 12.8, 14.5 and 15.8o.

81. The crystalline form of claim 79, which has an X-ray powder diffraction pattern (Cu K ^ radiation) substantially the same as the X-ray powder diffraction pattern shown in Figure 1.

82. The crystalline form of claim 79, which has an X-ray powder diffraction pattern (Cu K ^ radiation) with at least five specific peaks at about 2-theta = 6.9, 8.2, 9.2, 11.5, and 15.9o.

83. The crystalline form of claim 79, which has an X-ray powder diffraction pattern (Cu K ^ radiation) substantially the same as the X-ray powder diffraction pattern shown in Figure 2.

84. The crystalline form of claim 79, which has an X-ray powder diffraction pattern (Cu K ^ radiation) with at least five specific peaks at about 2-theta = 7.0, 7.7, 14.0, 16.1 and 16.9o.

85. The crystalline form of claim 79, which has an X-ray powder diffraction pattern (Cu K ^ radiation) substantially the same as the X-ray powder diffraction pattern shown in Figure 3.

86. The crystalline form of claim 79, which has an X-ray powder diffraction pattern (Cu K ^ radiation) with at least five specific peaks at about 2-theta = 6.1, 7.5, 8.2, 14.5 and 15.6o.

87. The crystalline form of claim 79, which has an X-ray powder diffraction pattern (Cu K ^ radiation) substantially the same as the X-ray powder diffraction pattern shown in Figure 4.

88. A crystalline form of the compound having the formula:.

89. The crystalline form of claim 88, which has an X-ray powder diffraction pattern (Cu K ^ radiation) with at least five specific peaks at about 2-theta = 6.7, 10.5, 13.5, 15.2 and 18.6o.

90. The crystalline form of claim 88, which has an X-ray powder diffraction pattern (Cu K ^ radiation) substantially the same as the X-ray powder diffraction pattern shown in Figure 5.

91. The crystalline form of claim 88, which has an X-ray powder diffraction pattern (Cu K ^ radiation) with at least five specific peaks at about 2-theta = 6.0, 7.6, 8.6, 19.0 and 20.2o.

92. The crystalline form of claim 88, which has an X-ray powder diffraction pattern (Cu K ^ radiation) substantially the same as the X-ray powder diffraction pattern shown in Figure 6.

93. A crystalline form of the compound having the formula:.

94. The crystalline form of claim 93, which has an X-ray powder diffraction pattern (Cu K ^ radiation) with at least five specific peaks at about 2-theta = 6.0, 7.5, 8.5, 17.5 and 19.4o.

95. The crystalline form of claim 93, which has an X-ray powder diffraction pattern (Cu K ^ radiation) substantially the same as the X-ray powder diffraction pattern shown in Figure 7.

96. The crystalline form of claim 93, which has an X-ray powder diffraction pattern (Cu K ^ radiation) with at least five specific peaks at about 2-theta = 4.7, 6.1, 7.7, 9.3 and 13.0o.

97. The crystalline form of claim 93, which has an X-ray powder diffraction pattern (Cu K ^ radiation) substantially the same as the X-ray powder diffraction pattern shown in Figure 8.

98. A pharmaceutical composition comprising the crystalline form of any one of claims 79- 97 and a pharmaceutically acceptable excipient.

Images