Antibodies against B and T lymphocytes, isolated nucleic acids, and expression vectors including isolated nucleic acids.

Abstract

The invention relates to an antibody against B and T lymphocyte altenuator (BTLA) or its antigenic linker comprising at least one light-chain CDR region selected from SEQ ID NOs: 7, 8, 9, 10, 11, 12, 16, 17, 18, 22, 23, 24, 31, 32 and 33, and / or at least one heavy-chain CDR region selected from SEQ ID NOs: 1, 2, 3, 4, 5, 6, 13, 14, 15, 19, 20, 21, 25, 26, 27, 28, 29 and 30. The invention also relates to the nucleic acid molecule encoding this antibody or its antigen-binding fragment, the corresponding expression vector and the host cell, as well as the therapeutic use of the antibody or its antigen-binding fragment, the nucleic acid molecule, the expression vector and the host cell.