Compounds, pharmaceutical salts, pharmaceutical preparations, and intermediary products in the production of Anti-cancer drugs

Abstract

The invention relates to a compound, pharmaceutical salt, pharmaceutical preparation, or intermediate product in the manufacture of an anticancer drug. The compound has the formula (I) or the pharmaceutical salt, stereoisopolymer, or the doterized compound thereof: in which: X1 is NH, o. or heterocyclic with 4 to 6 sides containing 1 to 3 diatomic elements selected from N and O; X? is 0 or one bond; X? and X.| each are independent C or NI; Ria and Rib each are independent H, D, or Ci-alkyl; or R|.| and Ru, forming 3 to 5-sided cycloalkyl with the carbon atom attached to it; Rín and Rjb each are independent H, D, or Ci-6 alkyl; or R?a and R?b forming 3 to 5-sided cycloalkyl with the carbon atom attached to it; R is H, D, C1-6 alkyl, halogen, or cyano, where the C1-6 alkyl is optionally substituted with 1 to 3 halogens; RI and Rs are each independent H, D, or C1-6 alkyl, or Ra and Rs form a 3- to 5-membered cycloalkyl with the carbon atom attached to it; Re and R are each independent H, D, or C1-6 alkyl; or Ro and R create a 0 on the carbon atom attached to it; R and Rp are each independent H, D, or C1-6 alkyl; or Re and Ro create a 0 on the carbon atom attached to it; or K> and R'J create 3- to 5-membered cycloalkyl atoms together with the carbon atom bonded to it; each independent R]0 is Ci-6 alkyl, Ci-6 alkoxy, CONRiíbRioh, halogen, cyano, S(O>2Ri0t, SRiod or 3- to 5-membered cycloalkyl atoms, in which C1-6 alkyl and Ci-6 alkoxy are optionally substituted with 1 to 3 halogens; Riùa, Riob, R]ftc and RiQd each are H: D, or independent Ci-6 alkyl; A is a C1-6 alkyl, C3-5 cycloalkyl, halogen, or cyano-alkyl alkyl, in which C1-e alkyl is optionally conjugated with 1 to 3 halogens; B is a carbon ring or heterocycle with 5 to 10 sides containing 1 to 3 heteroatoms selected from M0 and S; c is a heterocycle with 5 to 6 sides containing 1 to 3 heteroatoms of the element N; m is 1, 2, or 3; n is 0, 2, or 3; and p is 0, 1, 2, or 3.