ORAL-DOSE SLOW-RELEASE MEDICATIONS FOR DISTRIBUTION TO THE LARGE INTESTINE

Abstract

The invention relates to a method for producing a core suitable for an orally administered slow-release drug preparation for delivery to the colon. The method comprises a core preparation step. The outer coating is prepared by combining a first aqueous preparation of an enzymatically biodegradable polymer that is biodegradable by microbial enzymes in the colon; a second aqueous preparation of an enteric film-forming polymer with a pH threshold of approximately pH 6 or higher; and an organic anti-adhesion agent. The core is then coated with the outer coating to form a coated core.