Cyclic peptides are used to trap interleukin-1 beta and in pharmaceuticals containing it.

VN129065APending Publication Date: 2026-09-15MERCK SHARP & DOHME LLC
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Patent Information

Application Number
VN1202604899
Authority / Receiving Office
VN · VN
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-11-07
Filing Date
2024-11-12
Publication Date
2026-09-15

AI Technical Summary

Technical Problem

Current treatments for atherosclerosis and related cardiovascular diseases primarily focus on cholesterol-lowering medications, which do not adequately address the inflammatory component associated with interleukin-1 beta (IL-1β) in the progression of these diseases.

Method used

Development of cyclic peptides that specifically bind to IL-1β, preventing its engagement with the IL-1 receptor and thereby inhibiting downstream pro-inflammatory signaling, offering a novel therapeutic approach for treating cardiovascular diseases and inflammatory disorders.

Benefits of technology

The cyclic peptides effectively trap IL-1β, reducing inflammation and potentially slowing the progression of atherosclerosis and other cardiovascular diseases, while also providing an orally administered option for patients with inflammatory disorders.

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Abstract

The invention relates to a compound having the formula (I): , or its pharmaceutical salt, where X1, X2, X3, R1–R9, RA, RB, RD, A1, A2, and the subscripts t and w are as defined in the description. The compound and its pharmaceutical salt are capable of trapping IL-1β and are intended to be useful as therapeutic agents, for example, for the treatment of cardiovascular disease and inflammatory disorders. The invention also proposes a pharmaceutical composition which includes the compound expressed herein or its pharmaceutical salts. The invention also relates to methods of using the compound or its pharmaceutical salt in the treatment and prevention of cardiovascular disease and inflammatory disorders and the preparation of a pharmaceutical composition for this purpose.
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