Human monoclonal antibody against nipah virus glycoprotein g and use thereof
WO2024260397A1PCT designated stage expired Publication Date: 2024-12-26WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
Patent Information
- Application Number
- PCT/CN2024/100272
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-06-21
- Filing Date
- 2024-06-20
- Publication Date
- 2024-12-26
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Figure CN2024100272_26122024_PF_FP_ABST
Abstract
Provided are a human monoclonal antibody against Nipag virus glycoprotein G and a use thereof. The antibody can specifically bind to Nipah virus envelope protein with high affinity, has effective neutralizing activity against Nipah pseudovirus having VSV as a backbone, can effectively neutralize Nipah virus at the cellular level, and can completely protect hamsters infected with Nipah virus. The antibody is directed against an epitope that is different from reported neutralizing epitopes. Thus, the antibody is expected to become a novel specific antibody drug for prevention and treatment of Nipah virus, providing more options for prevention and control of Nipah virus.
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Citation Information
Patent Citations
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