Antimicrobial coated substrate

A sol-gel coating using hexamethyldisiloxane for medical implants addresses the challenges of coating integrity and release control, offering rapid curing and sustained antimicrobial efficacy, enhancing infection prevention during surgical procedures.

WO2025003679A1PCT designated stage expired Publication Date: 2025-01-02SHEFFIELD HALLAM UNIVERSITY
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Patent Information

Application Number
PCT/GB2024/051654
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-06-29
Filing Date
2024-06-27
Publication Date
2025-01-02

AI Technical Summary

Technical Problem

Conventional antibacterial sol-gel coatings for medical implants face challenges such as coating integrity, uncontrolled antimicrobial release, and slow curing processes, making them unsuitable for rapid application in the operating theatre.

Method used

A sol-gel derived coating using a siloxane monomer like hexamethyldisiloxane, which rapidly cures at ambient temperature, providing a durable, porous network for controlled antimicrobial release, and can be applied during surgery, ensuring stability and effectiveness.

Benefits of technology

The coating effectively prevents microbial contamination, provides sustained antimicrobial release, and maintains integrity during surgical procedures, reducing the risk of infections and antimicrobial resistance.

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Abstract

The invention relates to a substrate having a hybrid coating chemically bonded thereto, wherein the coating optionally comprises an antimicrobial component releasably captured within a polysiloxane based network of silicon-carbon bonds and silicon- oxygen bonds. The invention extends to a biocompatible implant comprising such a coated substrate, and a method of preparing such a coated substrate.
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Citation Information

Patent Citations

  • Xerogel films for the controlled release of pharmaceutically active molecules

    WO2006115805A2

  • Antimicrobial coating

    WO2010023483A2

  • Antimicrobial Coating

    US20110311591A1