Compositions in the form of a urea powder

UreaAide sparkling, a flavored urea powder composition, addresses the taste and adherence issues of conventional hyponatremia treatments by enhancing taste tolerability and patient compliance, offering a cost-effective and effective sodium supplementation solution for hyponatremia management.

WO2025006368A2PCT designated stage expired Publication Date: 2025-01-02KIDNEYAIDE
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Patent Information

Application Number
PCT/US2024/035195
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-06-24
Filing Date
2024-06-24
Publication Date
2025-01-02

AI Technical Summary

Technical Problem

Conventional treatments for hyponatremia, such as fluid restriction and oral sodium chloride tablets, face challenges including low patient adherence, adverse side effects, and inadequate sodium level correction, while urea therapy is limited by its unpleasant taste and high cost, leading to compliance issues.

Method used

A stable powder composition of urea, known as UreaAide sparkling, is developed, which includes flavor enhancers like Agave powder, lemon and orange flavoring, and bitter blockers to improve taste tolerability, and is available in various flavors, packaged as single-use dose packets for flexible administration.

Benefits of technology

UreaAide sparkling enhances patient compliance by masking the unpleasant taste of urea, providing effective sodium supplementation with improved adherence and cost-effectiveness compared to traditional treatments, while maintaining safety and efficacy in correcting hyponatremia.

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Abstract

The disclosure relates to an improved composition of a mixture based on urea. The present disclosure can be broadly described as a more stable powder composition comprising an amount of urea effective for treatment of hyponatremia. The present disclosure is a urea formulation that is a sparkling Urea (may be referred to below as "UreaAide sparkling"). The usual starting dose of urea is 15 grams, twice a day. The UreaAide sparkling is a powder that can come in single use urea dose packet. In one embodiment, the UreaAide sparkling is a single use, 15 gram urea dose packet. The 15 gram urea dosage may vary. For example, the urea dosage may not be a 15 gram dose. The urea dose can be prescribed to be taken once per day or many times throughout the day.
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