Readily manufacturable flow channel devices

Flow inserts with a pressure-sensitive adhesive address the limitations of current microphysiological systems by enabling non-destructive real-time monitoring and fluidic flow simulation, improving the assessment of therapeutic agents and reducing drug development costs.

WO2025006642A2PCT designated stage expired Publication Date: 2025-01-02UNIVERSITY OF ROCHESTER
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Patent Information

Application Number
PCT/US2024/035671
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-06-26
Filing Date
2024-06-26
Publication Date
2025-01-02

AI Technical Summary

Technical Problem

Current microphysiological systems, such as organs-on-a-chip and tissues-on-a-chip, face challenges in non-destructive real-time monitoring of cell responses and fluid flow simulation, leading to increased costs, variability, and decoupling of sensors from the tissue or organ model, which limits their effectiveness in predicting drug safety and efficacy.

Method used

The development of flow inserts with a pressure-sensitive adhesive that securely attaches to the apical surface of microphysiological systems, creating a flow channel over ultrathin membranes without the need for precise magnetic alignment or plasma bonding, allowing for easy conversion between static and fluidic conditions and enabling fluidic flow simulation.

Benefits of technology

This solution enables cost-effective, scalable, and reliable manufacturing of flow inserts that allow for real-time, non-destructive monitoring of cell responses and improved simulation of physiological fluid flow, enhancing the ability to assess therapeutic agent effects and recapitulate cell interactions, thereby reducing the risk of drug failures in clinical trials.

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Abstract

The disclosure provides flow inserts and flow devices. The flow inserts provide a flow path over cells growing on an ultrathin membrane disposed in a microphysiological system (MPS), providing fluidic flow conditions to cells under the flow path. In some embodiments, the disclosure provides "half flow inserts" that cover cells growing on a first ultrathin membrane but not those growing on a second ultrathin membrane on the same membrane chip, allowing cells on the covered ultrathin membrane to grow under fluidic flow conditions, while cells on the second, uncovered ultrathin membrane grow in a static culture medium. The invention further provides flow devices that allow providing fluidic flow conditions on standard optically-clear laboratory equipment, such as microscope slides, that do not ordinarily have such conditions available
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Citation Information

Patent Citations

  • Devices and methods for monitoring cells, tissues, or organs-on-a-chip

    WO2022099161A1