Chemically induced reprogramming to reverse aging

Chemical cocktails targeting specific cellular compounds reverse cellular aging by restoring youthful gene expression profiles, addressing the limitations of genetic methods with safer and more cost-effective whole-body rejuvenation.

WO2025006954A2PCT designated stage expired Publication Date: 2025-01-02PRESIDENT & FELLOWS OF HARVARD COLLEGE
View PDF 0 Cites 0 Cited by

Patent Information

Application Number
PCT/US2024/036117
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-06-30
Filing Date
2024-06-28
Publication Date
2025-01-02

AI Technical Summary

Technical Problem

Current methods for reversing cellular aging, such as using genetic means like adeno-associated viruses or lipid nanoparticles, face challenges including high costs, regulatory hurdles, and safety concerns, particularly for whole-body rejuvenation, and often result in unintended toxicities like teratomas and dysplasia.

Method used

The use of chemical cocktails comprising compounds like laduviglusib, RepSox, ascorbic acid, valproic acid, and forskolin to rejuvenate cells by reversing transcriptomic age without erasing cellular identity, utilizing a quantitative nucleocytoplasmic compartmentalization assay to distinguish between young, old, and senescent cells.

Benefits of technology

This approach safely mimics the rejuvenating effects of OSK overexpression, reducing development costs and timelines for regenerative medicines, effectively reversing cellular aging and restoring youthful gene expression profiles in a matter of weeks without inducing pluripotency or tumorigenesis.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure US2024036117_02012025_PF_FP_ABST
    Figure US2024036117_02012025_PF_FP_ABST
Patent Text Reader

Abstract

Provided herein are methods of rejuvenating, restoring cellular function to, decreasing the biological age of, decreasing the apparent chronological age of, and reprogramming cells, organs, and tissues, using chemical cocktails comprising two or more compounds described herein, or pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, or prodrugs thereof. Also provided herein are methods of treating a disease, methods of monitoring cellular aging, and pharmaceutical compositions and kits using two or more compounds described herein, or pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, or prodrugs thereof.
Need to check novelty before this filing date? Find Prior Art