Compositions and methods for treating cancer

Modified Stella peptides and nucleic acid molecules are used to modulate UHRF1 protein activity, addressing the challenge of treating colorectal cancer by inhibiting abnormal DNA methylation maintenance and reactivating tumor suppressor genes.

WO2025064873A2 Publication Date: 2025-03-27JOHNS HOPKINS UNIVERSITY
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Patent Information

Application Number
PCT/US2024/047764
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-09-20
Filing Date
2024-09-20
Publication Date
2025-03-27

AI Technical Summary

Technical Problem

Current treatments for cancer, particularly colorectal cancer, are limited in effectively targeting and modulating the UHRF1 protein, which plays a crucial role in maintaining abnormal DNA methylation patterns associated with cancer.

Method used

The development of compositions comprising modified peptides, specifically mutated or synthetic Stella peptides and nucleic acid molecules encoding these peptides, which can modulate the expression or activity of the UHRF1 protein. These peptides exhibit substantial sequence identity to native Stella proteins and can inhibit UHRF1's binding to DNA methylation sites, histones, and chromatin.

Benefits of technology

The proposed solution effectively inhibits UHRF1's maintenance of abnormal DNA methylation, leading to potential therapeutic benefits in treating various cancers, including colorectal cancer, by reactivating epigenetically silenced tumor suppressor genes.

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Abstract

Compositions are provided that comprise one or more modified peptides that can modulate the expression or activity of Ubiquitin Like With PHD And Ring Finger Domains (UHRF1) protein. In a particular aspect, compositions are provided that comprise one or more mutated or synthetic Stella peptides, or nucleic acid molecules encoding one or more mutated or synthetic Stella peptides. The compositions can be particularly useful for treatment of a variety of cancers in subjects, including colorectal cancer.
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