Compositions and methods for precision editing with CAS dimers
WO2025072763A2PCT designated stage expired Publication Date: 2025-04-03MAMMOTH BIOSCIENCES INC
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Patent Information
- Application Number
- PCT/US2024/048981
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-08-22
- Filing Date
- 2024-09-27
- Publication Date
- 2025-04-03
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Figure US2024048981_03042025_PF_FP_ABST
Abstract
Disclosed herein are systems, composition and methods of modifying a target double-stranded DNA (dsDNA) molecule in a cell. In general, systems, compositions, and methods comprise a compact, dimerizing CRISPR-associated (Cas) protein, an RNA-dependent DNA polymerase, and one or more guide nucleic acids, or uses thereof.
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