Oral pharmaceutical composition of glp-1 receptor agonist and preparation method therefor

WO2025252098A1PCT designated stage Publication Date: 2025-12-11HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL CO LTD
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Patent Information

Application Number
PCT/CN2025/098931
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-06-05
Filing Date
2025-06-04
Publication Date
2025-12-11

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Abstract

A pharmaceutical composition containing (S)-2-((4-(6-((2-fluoro-4-(oxetan-3-yl)benzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylic acid ("OAD2") or a pharmaceutically acceptable salt thereof, and a preparation method for the pharmaceutical composition. The dissolution of the provided pharmaceutical composition is good, the total content of impurities is low, and the pharmaceutical composition can be stably stored under normal temperature and humidity conditions.
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Citation Information

Patent Citations

  • GLP-1 receptor agonists and uses thereof

    CN110325530A

  • GLP-1 small molecule with cardiovascular benefits

    CN113773310A

  • Treatment of type 2 diabetes or obesity or overweight with 2-[(4-{6-[(4-cyano-2-fluorobenzyl) oxy] pyridin-2-yl} piperidin-1-yl) methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazol-6-carboxylic acid or pharmaceutical salt thereof

    CN115348863A

  • Heterocyclic GLP-1 agonists

    CN116547279A

  • GLP-1 receptor agonist and composition and application thereof

    CN117362283A