Composition for preventing or treating sepsis, comprising papiliocin derivative as active ingredient
WO2026010398A1PCT designated stage Publication Date: 2026-01-08KONKUK UNIV IND COOP CORP +1
Patent Information
- Application Number
- PCT/KR2025/009522
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-07-03
- Filing Date
- 2025-07-03
- Publication Date
- 2026-01-08
Smart Images
Figure KR2025009522_08012026_PF_FP_ABST
Abstract
The present invention relates to a composition for preventing or treating sepsis, comprising a papiliocin derivative as an active ingredient. When the papiliocin derivative peptide of the present invention is used, an antibacterial effect targeting LPS of the cell membrane of Gram-negative bacteria and an anti-inflammatory effect through inhibition of the TLR4 signaling pathway can be obtained at the same time. In addition, the papiliocin derivative peptide of the present invention exhibits an antibacterial effect against Gram-negative bacteria and Gram-positive bacteria, and thus can be effectively used for an antibiotic use against Gram-negative bacteria and Gram-positive bacteria and for the prevention or treatment of sepsis caused by bacterial infection. In particular, since the development of antibiotics against carbapenem- or colistin-resistant bacteria is insufficient, the present invention is considered to have high industrial applicability.
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Citation Information
Patent Citations
Peptide analogue with high antibacterial and Anti-inflammatory activities designed from papiliocin peptide
KR1020110139947A
Mass-producted method of papiliocin using recombinant escherichia coli
KR1020120044167A
Capacitively-coupled plasma substrate processing apparatus including a sheild ring
KR1020210055470A