2,4-diphenyl-3,4-dihydroquinazoline derivatives and related compounds as d 2 dopamine receptor-selective antagonists

Abstract

This disclosure provides compounds of Formula I and the pharmaceutically acceptable salts thereof. The variables, e.g., R1-R6, L, and W are defined herein. The compounds of the disclosure are highly selective D2 receptor antagonists, useful for treating schizophrenia, depression, bipolar disorder, post-operative nausea or vomiting, Tourette's syndrome, tardive dyskinesia, Huntington's chorea, and gastroesophageal reflux disease. The disclosure also provides pharmaceutical compositions comprising a compound or salt of Formula I.

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