Pistacia-derived bioactive peptides encapsulated in soy protein nanoparticles as an anticancer drug

Encapsulating Pistacia-derived bioactive peptides in soy protein nanoparticles addresses the challenges of peptide instability and delivery, achieving enhanced stability, solubility, and targeted cancer cell delivery with reduced side effects.

WO2026018050A1PCT designated stage Publication Date: 2026-01-22ZARE-ZARDINI HADI +4
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Patent Information

Application Number
PCT/IB2024/056839
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-07-14
Publication Date
2026-01-22

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Abstract

This invention evaluates the anticancer activity of novel bioactive peptides derived from Pistacia species, both in their purified form and when encapsulated in Soy Protein Isolate (SPI) nanoparticles, against various cancer cell lines and non- cancerous cells. Pistacia proteins were enzymatically hydrolyzed, and two new bioactive peptides, Pistacia-Zardin1 (Leu-Ala-Asn-Ala-Arg) and Pistacia-Zardin2 (Val-Asn-Val-Lys-Arg-Ala), were isolated using HPLC. These peptides were encapsulated in SPI nanoparticles via the desolvation method to enhance their stability, solubility, and targeted delivery, achieving average nanoparticle sizes of 100 nm and 110 nm, respectively. Both free and nanoparticle-loaded forms of these peptides demonstrated significant inhibitory activity against OVCAR3, MCF-7, and AGS cancer cell lines without significant toxicity to normal cells, indicating a favorable safety profile compared to traditional chemotherapeutic agents like Doxorubicin. This approach addresses key challenges in cancer treatment by improving the therapeutic potential and delivery of bioactive peptides.
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Patent Citations

  • Anticancer peptides

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  • Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of Anti-cancer drugs

    NZ576769A

  • Anticancer activity of chios mastic gum

    WO2005112967A2

  • Nanoparticle drug delivery systems

    WO2014121291A2

  • Peptide compounded solid beverage for tonifying five internal organs, and preparation method thereof

    CN108902619A