Saccharomyces eubayanus maltotriose transporters and uses thereof

Engineered MalT4 proteins with targeted amino acid substitutions enhance maltotriose transport in Saccharomyces eubayanus yeast, addressing the fermentation challenge and improving beer quality.

WO2026020145A1PCT designated stage Publication Date: 2026-01-22WISCONSIN ALUMNI RES FOUND
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Patent Information

Application Number
PCT/US2025/038324
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-07-19
Filing Date
2025-07-18
Publication Date
2026-01-22

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Abstract

The present invention provides engineered Saccharomyces eubayanus MalT4 proteins that have maltotriose transport activity. Also provided are polypeptides, constructs, and vectors encoding the engineered MalT4 proteins, as well as S. eubayanus yeast cells that express the engineered MalT4 proteins and methods of using these cells to make a fermentation product, such as a lager.
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Citation Information

Patent Citations

  • Polypeptide and yeast cell compositions and methods of using the same

    US11028402B2

  • Polypeptide and yeast cell compositions and methods of using the same

    US20190315815A1