Membrane-anchored or secretory cytokines, engineered immune cells, and uses thereof
WO2026037407A1PCT designated stage Publication Date: 2026-02-19CHENGDU UCELLO BIOTECHNOLOGY CO LIMITED
Patent Information
- Application Number
- PCT/CN2025/115026
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-08-16
- Filing Date
- 2025-08-15
- Publication Date
- 2026-02-19
AI Technical Summary
Technical Problem
Current CAR-T cell therapy involves lymphodepletion, which complicates the medical procedure, increases patient burden, and risks infection and cytokine release syndrome due to indiscriminate stimulation of immune cells.
Method used
A composition comprising a cytokine peptide, such as cytomegalovirus IL-10 (cmvIL-10), anchored to cells via a signal peptide or engineered targeting moiety, allowing targeted proliferation and survival of select immune cells.
Benefits of technology
Enhances the proliferation and survival of targeted immune cells while minimizing stimulation of undesirable lymphocytes, reducing the risk of cytokine release syndrome and infection.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN2025115026_19022026_PF_FP_ABST
Abstract
The present disclosure relates to a nucleic acid molecule, a polypeptide, a protein, a cell, or a system comprising a cytokine, optionally a targeting moiety (e.g., a chimeric antigens receptor), and / or an anchoring structure that can attach to the surface of a cell (e.g., an engineered immune cell), and the methods to prepare the same and to use the same to treat a disease or a condition.
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Citation Information
Patent Citations
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Membrane-anchored cytokines, engineered immune cells, and uses thereof
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